Vasotoxic Effects of Anticancer Therapy: a Review of Current Data
Cardiovascular and oncological diseases are the leading causes of adult death in the world. Despite proven efficacy, anticancer drugs can cause severe cardiovascular complications. Recently, data have appeared on the possible vasotoxic effects of chemotherapy drugs, which can manifest themselves as...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2023-05-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/2841 |
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| author | Yu. A. Vasyuk E. Y. Shupenina A. G. Nosova E. O. Novosel D. A. Vyzhigin |
| author_facet | Yu. A. Vasyuk E. Y. Shupenina A. G. Nosova E. O. Novosel D. A. Vyzhigin |
| author_sort | Yu. A. Vasyuk |
| collection | DOAJ |
| description | Cardiovascular and oncological diseases are the leading causes of adult death in the world. Despite proven efficacy, anticancer drugs can cause severe cardiovascular complications. Recently, data have appeared on the possible vasotoxic effects of chemotherapy drugs, which can manifest themselves as the progression of arterial hypertension and atherosclerosis, the development of myocardial ischemia and acute coronary syndrome, the formation of venous and arterial thrombosis. The key mechanism for the development of vasotoxicity is endothelial dysfunction, and anticancer drugs can also affect the processes of thrombosis. The review presents the results of 12 selected observational retro- and prospective studies involving cancer patients receiving presumably vasotoxic therapy. Data on the frequency of occurrence and possibilities for the prevention of vasotoxicity are presented. |
| format | Article |
| id | doaj-art-28539d3dbf42428ea50a2e8098e31d19 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-28539d3dbf42428ea50a2e8098e31d192025-08-23T10:00:36ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532023-05-0119220320810.20996/1819-6446-2023-03-032117Vasotoxic Effects of Anticancer Therapy: a Review of Current DataYu. A. Vasyuk0E. Y. Shupenina1A. G. Nosova2E. O. Novosel3D. A. Vyzhigin4Moscow State University of Medicine and Dentistry after A.I. EvdokimovMoscow State University of Medicine and Dentistry after A.I. EvdokimovMoscow State University of Medicine and Dentistry after A.I. EvdokimovMoscow State University of Medicine and Dentistry after A.I. EvdokimovMoscow State University of Medicine and Dentistry after A.I. EvdokimovCardiovascular and oncological diseases are the leading causes of adult death in the world. Despite proven efficacy, anticancer drugs can cause severe cardiovascular complications. Recently, data have appeared on the possible vasotoxic effects of chemotherapy drugs, which can manifest themselves as the progression of arterial hypertension and atherosclerosis, the development of myocardial ischemia and acute coronary syndrome, the formation of venous and arterial thrombosis. The key mechanism for the development of vasotoxicity is endothelial dysfunction, and anticancer drugs can also affect the processes of thrombosis. The review presents the results of 12 selected observational retro- and prospective studies involving cancer patients receiving presumably vasotoxic therapy. Data on the frequency of occurrence and possibilities for the prevention of vasotoxicity are presented.https://www.rpcardio.online/jour/article/view/2841cancer patientvasotoxicityendothelial dysfunctionvenous thromboembolismarterial thrombosischemotherapyalkylating agent, antimetabolitestyrosine kinase inhibitorsvascular endothelial growth factor |
| spellingShingle | Yu. A. Vasyuk E. Y. Shupenina A. G. Nosova E. O. Novosel D. A. Vyzhigin Vasotoxic Effects of Anticancer Therapy: a Review of Current Data Рациональная фармакотерапия в кардиологии cancer patient vasotoxicity endothelial dysfunction venous thromboembolism arterial thrombosis chemotherapy alkylating agent , antimetabolites tyrosine kinase inhibitors vascular endothelial growth factor |
| title | Vasotoxic Effects of Anticancer Therapy: a Review of Current Data |
| title_full | Vasotoxic Effects of Anticancer Therapy: a Review of Current Data |
| title_fullStr | Vasotoxic Effects of Anticancer Therapy: a Review of Current Data |
| title_full_unstemmed | Vasotoxic Effects of Anticancer Therapy: a Review of Current Data |
| title_short | Vasotoxic Effects of Anticancer Therapy: a Review of Current Data |
| title_sort | vasotoxic effects of anticancer therapy a review of current data |
| topic | cancer patient vasotoxicity endothelial dysfunction venous thromboembolism arterial thrombosis chemotherapy alkylating agent , antimetabolites tyrosine kinase inhibitors vascular endothelial growth factor |
| url | https://www.rpcardio.online/jour/article/view/2841 |
| work_keys_str_mv | AT yuavasyuk vasotoxiceffectsofanticancertherapyareviewofcurrentdata AT eyshupenina vasotoxiceffectsofanticancertherapyareviewofcurrentdata AT agnosova vasotoxiceffectsofanticancertherapyareviewofcurrentdata AT eonovosel vasotoxiceffectsofanticancertherapyareviewofcurrentdata AT davyzhigin vasotoxiceffectsofanticancertherapyareviewofcurrentdata |