Use of a specialized peptide-based enteral formula containing medium-chain triglycerides for enteral tube feeding in children with cerebral palsy and previous tube feeding intolerance on standard enteral formula: a prospective observational TolerUP study
ObjectiveUse of peptide-based formulas supplemented with medium chain triglycerides (MCTs) is considered a beneficial strategy to decrease the tube-feeding associated gastrointestinal tolerance. In children with cerebral palsy (CP), overall effects of enteral tube feeding as well as the utility of p...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1448507/full |
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| author | Aydan Kansu Gunsel Kutluk Gonul Caltepe Cigdem Arikan Nafiye Urganci Gokhan Tumgor Aysel Yuce Ceyda Tuna Kirsaclioglu Arzu Meltem Demir Fatma Demirbas Merve Usta Sibel Yavuz Duygu Demirtas Guner Ersin Gumus Buket Dalgic Yasar Dogan Nelgin Gerenli Halil Kocamaz Fulya Gulerman Elif Sag Aysugul Alptekin Sarioglu Neslihan Eksi Bozbulut Demet Teker Duztas Hatice Altug Demirol Coskun Celtik Olcay Gungor Kaan Demiroren Aysen Uncuoglu Aydogan Ozlem Bekem Zeynep Arslan Murat Cakir Arzu Ekici Nihal Uyar Aksu Cigdem Ecevit Simge Erdogan |
| author_facet | Aydan Kansu Gunsel Kutluk Gonul Caltepe Cigdem Arikan Nafiye Urganci Gokhan Tumgor Aysel Yuce Ceyda Tuna Kirsaclioglu Arzu Meltem Demir Fatma Demirbas Merve Usta Sibel Yavuz Duygu Demirtas Guner Ersin Gumus Buket Dalgic Yasar Dogan Nelgin Gerenli Halil Kocamaz Fulya Gulerman Elif Sag Aysugul Alptekin Sarioglu Neslihan Eksi Bozbulut Demet Teker Duztas Hatice Altug Demirol Coskun Celtik Olcay Gungor Kaan Demiroren Aysen Uncuoglu Aydogan Ozlem Bekem Zeynep Arslan Murat Cakir Arzu Ekici Nihal Uyar Aksu Cigdem Ecevit Simge Erdogan |
| author_sort | Aydan Kansu |
| collection | DOAJ |
| description | ObjectiveUse of peptide-based formulas supplemented with medium chain triglycerides (MCTs) is considered a beneficial strategy to decrease the tube-feeding associated gastrointestinal tolerance. In children with cerebral palsy (CP), overall effects of enteral tube feeding as well as the utility of peptide-based specialized enteral formulas in those with gastrointestinal intolerance have not been extensively studied. This study aimed to evaluate the utility of enteral tube feeding via specialized peptide-based formula containing MCTs in children with CP in terms of gastrointestinal intolerance, anthropometrics, defecation characteristics and parental satisfaction with enteral formula.MethodsChildren with CP who received enteral tube feeding via specialized peptide-based formula containing MCTs were included in this prospective observational study. Anthropometrics (z scores for weight for age [WFA], weight for height [WFH], triceps skinfold thickness [TSFT] and mid-upper arm circumference [MUAC]), gastrointestinal intolerance symptoms, defecation frequency and stool patterns and formula satisfaction were recorded at baseline and during 6-month follow up.ResultsA total of 96 children with CP (mean ± SD age: 5.6 ± 3.2 years, 56.3% were boys) were included. Significant improvements were noted in MUAC, TSFT and WFH z scores at the 6th month visit. The rate of “severe symptoms” and the likelihood of Type-1/Type-2 (constipation) stool pattern were significantly decreased. Majority of parents were satisfied with the study formula.ConclusionOur findings revealed favorable efficacy and safety of using a specialized peptide-based formula containing MCT in provision of enteral tube feeding among children with CP in terms of improved anthropometrics, amelioration of gastrointestinal intolerance symptoms and normalization of bowel movements along with a high parental satisfaction. |
| format | Article |
| id | doaj-art-2849e63ab192419d905abd91a50618da |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-2849e63ab192419d905abd91a50618da2025-02-12T07:26:41ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-02-011310.3389/fped.2025.14485071448507Use of a specialized peptide-based enteral formula containing medium-chain triglycerides for enteral tube feeding in children with cerebral palsy and previous tube feeding intolerance on standard enteral formula: a prospective observational TolerUP studyAydan Kansu0Gunsel Kutluk1Gonul Caltepe2Cigdem Arikan3Nafiye Urganci4Gokhan Tumgor5Aysel Yuce6Ceyda Tuna Kirsaclioglu7Arzu Meltem Demir8Fatma Demirbas9Merve Usta10Sibel Yavuz11Duygu Demirtas Guner12Ersin Gumus13Buket Dalgic14Yasar Dogan15Nelgin Gerenli16Halil Kocamaz17Fulya Gulerman18Elif Sag19Aysugul Alptekin Sarioglu20Neslihan Eksi Bozbulut21Demet Teker Duztas22Hatice Altug Demirol23Coskun Celtik24Olcay Gungor25Kaan Demiroren26Aysen Uncuoglu Aydogan27Ozlem Bekem28Zeynep Arslan29Murat Cakir30Arzu Ekici31Nihal Uyar Aksu32Cigdem Ecevit33Simge Erdogan34Department of Pediatric Gastroenterology, Ankara University School of Medicine, Ankara, TürkiyeDepartment of Pediatric Gastroenterology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, TürkiyeDepartment of Pediatric Gastroenterology, Ondokuz Mayis University Faculty of Medicine, Samsun, TürkiyeDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Koc University Faculty of Medicine, Istanbul, TürkiyeDepartment of Pediatric Gastroenterology, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, TürkiyeDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cukurova University Faculty of Medicine, Adana, TürkiyeDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Hacettepe University Faculty of Medicine, Ankara, TürkiyeDepartment of Pediatric Gastroenterology, Ankara University School of Medicine, Ankara, TürkiyeDepartment of Pediatric Gastroenterology, Ankara City Hospital, Ankara, TürkiyeDepartment of Pediatric Gastroenterology, Ondokuz Mayis University Faculty of Medicine, Samsun, TürkiyeDepartment of Pediatric Gastroenterology, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, TürkiyeDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cukurova University Faculty of Medicine, Adana, TürkiyeDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Hacettepe University Faculty of Medicine, Ankara, TürkiyeDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Hacettepe University Faculty of Medicine, Ankara, TürkiyeDepartment of Pediatric Gastroenterology, Gazi University Faculty of Medicine, Ankara, Türkiye0Department of Pediatric Gastroenterology, Firat University Faculty of Medicine, Elazig, Türkiye1Department of Pediatric Gastroenterology, Istanbul Umraniye Training and Research Hospital, Istanbul, Türkiye2Department of Pediatrics, Division of Pediatric Gastroenterology, Pamukkale University Faculty of Medicine, Denizli, Türkiye3Department of Pediatric Gastroenterology, Kirikkale University Faculty of Medicine, Kirikkale, Türkiye4Department of Pediatric Gastroenterology Hepatology and Nutrition, Karadeniz Technical University Faculty of Medicine, Trabzon, Türkiye5Abbott Laboratories, Istanbul, TürkiyeDepartment of Pediatric Gastroenterology, Gazi University Faculty of Medicine, Ankara, TürkiyeDepartment of Pediatric Gastroenterology, Gazi University Faculty of Medicine, Ankara, Türkiye0Department of Pediatric Gastroenterology, Firat University Faculty of Medicine, Elazig, Türkiye1Department of Pediatric Gastroenterology, Istanbul Umraniye Training and Research Hospital, Istanbul, Türkiye2Department of Pediatrics, Division of Pediatric Gastroenterology, Pamukkale University Faculty of Medicine, Denizli, Türkiye6Department of Pediatric Gastroenterology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Türkiye7Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Kocaeli University Faculty of Medicine, Kocaeli, Türkiye8Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Health Sciences Dr. Behcet Uz Children's Hospital, Izmir, Türkiye3Department of Pediatric Gastroenterology, Kirikkale University Faculty of Medicine, Kirikkale, Türkiye4Department of Pediatric Gastroenterology Hepatology and Nutrition, Karadeniz Technical University Faculty of Medicine, Trabzon, Türkiye9Department of Pediatric Neurology, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Türkiye7Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Kocaeli University Faculty of Medicine, Kocaeli, Türkiye8Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Health Sciences Dr. Behcet Uz Children's Hospital, Izmir, Türkiye5Abbott Laboratories, Istanbul, TürkiyeObjectiveUse of peptide-based formulas supplemented with medium chain triglycerides (MCTs) is considered a beneficial strategy to decrease the tube-feeding associated gastrointestinal tolerance. In children with cerebral palsy (CP), overall effects of enteral tube feeding as well as the utility of peptide-based specialized enteral formulas in those with gastrointestinal intolerance have not been extensively studied. This study aimed to evaluate the utility of enteral tube feeding via specialized peptide-based formula containing MCTs in children with CP in terms of gastrointestinal intolerance, anthropometrics, defecation characteristics and parental satisfaction with enteral formula.MethodsChildren with CP who received enteral tube feeding via specialized peptide-based formula containing MCTs were included in this prospective observational study. Anthropometrics (z scores for weight for age [WFA], weight for height [WFH], triceps skinfold thickness [TSFT] and mid-upper arm circumference [MUAC]), gastrointestinal intolerance symptoms, defecation frequency and stool patterns and formula satisfaction were recorded at baseline and during 6-month follow up.ResultsA total of 96 children with CP (mean ± SD age: 5.6 ± 3.2 years, 56.3% were boys) were included. Significant improvements were noted in MUAC, TSFT and WFH z scores at the 6th month visit. The rate of “severe symptoms” and the likelihood of Type-1/Type-2 (constipation) stool pattern were significantly decreased. Majority of parents were satisfied with the study formula.ConclusionOur findings revealed favorable efficacy and safety of using a specialized peptide-based formula containing MCT in provision of enteral tube feeding among children with CP in terms of improved anthropometrics, amelioration of gastrointestinal intolerance symptoms and normalization of bowel movements along with a high parental satisfaction.https://www.frontiersin.org/articles/10.3389/fped.2025.1448507/fullcerebral palsypeptide-based formulagastrointestinal intoleranceanthropometricsparental satisfaction |
| spellingShingle | Aydan Kansu Gunsel Kutluk Gonul Caltepe Cigdem Arikan Nafiye Urganci Gokhan Tumgor Aysel Yuce Ceyda Tuna Kirsaclioglu Arzu Meltem Demir Fatma Demirbas Merve Usta Sibel Yavuz Duygu Demirtas Guner Ersin Gumus Buket Dalgic Yasar Dogan Nelgin Gerenli Halil Kocamaz Fulya Gulerman Elif Sag Aysugul Alptekin Sarioglu Neslihan Eksi Bozbulut Demet Teker Duztas Hatice Altug Demirol Coskun Celtik Olcay Gungor Kaan Demiroren Aysen Uncuoglu Aydogan Ozlem Bekem Zeynep Arslan Murat Cakir Arzu Ekici Nihal Uyar Aksu Cigdem Ecevit Simge Erdogan Use of a specialized peptide-based enteral formula containing medium-chain triglycerides for enteral tube feeding in children with cerebral palsy and previous tube feeding intolerance on standard enteral formula: a prospective observational TolerUP study Frontiers in Pediatrics cerebral palsy peptide-based formula gastrointestinal intolerance anthropometrics parental satisfaction |
| title | Use of a specialized peptide-based enteral formula containing medium-chain triglycerides for enteral tube feeding in children with cerebral palsy and previous tube feeding intolerance on standard enteral formula: a prospective observational TolerUP study |
| title_full | Use of a specialized peptide-based enteral formula containing medium-chain triglycerides for enteral tube feeding in children with cerebral palsy and previous tube feeding intolerance on standard enteral formula: a prospective observational TolerUP study |
| title_fullStr | Use of a specialized peptide-based enteral formula containing medium-chain triglycerides for enteral tube feeding in children with cerebral palsy and previous tube feeding intolerance on standard enteral formula: a prospective observational TolerUP study |
| title_full_unstemmed | Use of a specialized peptide-based enteral formula containing medium-chain triglycerides for enteral tube feeding in children with cerebral palsy and previous tube feeding intolerance on standard enteral formula: a prospective observational TolerUP study |
| title_short | Use of a specialized peptide-based enteral formula containing medium-chain triglycerides for enteral tube feeding in children with cerebral palsy and previous tube feeding intolerance on standard enteral formula: a prospective observational TolerUP study |
| title_sort | use of a specialized peptide based enteral formula containing medium chain triglycerides for enteral tube feeding in children with cerebral palsy and previous tube feeding intolerance on standard enteral formula a prospective observational tolerup study |
| topic | cerebral palsy peptide-based formula gastrointestinal intolerance anthropometrics parental satisfaction |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1448507/full |
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