A novel nomogram for predicting the morbidity of chronic atrophic gastritis based on serum CXCL5 levels
Abstract Objective This study aimed to investigate the diagnostic potential of serum CXC chemokine ligand 5 (CXCL5) in patients with chronic atrophic gastritis (CAG) and to establish a prediction model for better diagnosis of CAG. Methods A retrospective analysis was conducted, encompassing 570 case...
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BMC
2025-01-01
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| Online Access: | https://doi.org/10.1186/s12885-024-13394-0 |
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| author | Bei Pei Qin Sun Yi Zhang Ziang Wen Wenjing Ding Kairui Wu Tingting Li Xuejun Li |
| author_facet | Bei Pei Qin Sun Yi Zhang Ziang Wen Wenjing Ding Kairui Wu Tingting Li Xuejun Li |
| author_sort | Bei Pei |
| collection | DOAJ |
| description | Abstract Objective This study aimed to investigate the diagnostic potential of serum CXC chemokine ligand 5 (CXCL5) in patients with chronic atrophic gastritis (CAG) and to establish a prediction model for better diagnosis of CAG. Methods A retrospective analysis was conducted, encompassing 570 cases of CAG patients admitted to the Department of Gastroenterology of the Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, who underwent gastroscopy and received pathologically confirmed diagnoses between June 2018 and June 2023. Additionally, 570 cases without CAG who underwent health checkups were included and classified into the control group. Single-factor and multi-factorial logistic regression analyses were employed to identify risk factors of CAG, and a prediction model for diagnosing CAG was developed using R software. The predictive performance of the constructed model was verified and evaluated through ROC analysis, decision curve analysis (DCA), and prediction efficacy curve. Results Multi-factorial logistic regression analysis revealed that history of smoking, family history of tumurs, Pepsinogen I (PG I), Gastrin 17 (G-17), Helicobacter pylori infection, D-dimer, and CXCL5 were independent risk factors in CAG patients. A nomogram for the diagnosis of CAG was constructed using R software. The ROC curve demonstrated that CXCL5 showed the best predictive efficacy as a single indicator, with an AUC of 0.897, a sensitivity of 0.789, and a specificity of 0.999. Furthermore, the nomogram exhibited an AUC of 0.992, a sensitivity of 0.958, and a specificity of 0.970. Calibration and DCA curves indicated that the predicted values of the nomogram were highly concordant with the observed values, thus demonstrating a high predictive value. Conclusion In this study, we found a correlation between serum CXCL5 level and CAG, and developed a prediction model to assist the clinical diagnosis of CAG. |
| format | Article |
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| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Cancer |
| spelling | doaj-art-2849279285d34e98a4126c0532cd08112025-01-12T12:27:36ZengBMCBMC Cancer1471-24072025-01-012511810.1186/s12885-024-13394-0A novel nomogram for predicting the morbidity of chronic atrophic gastritis based on serum CXCL5 levelsBei Pei0Qin Sun1Yi Zhang2Ziang Wen3Wenjing Ding4Kairui Wu5Tingting Li6Xuejun Li7The First Clinical Medical College, Anhui University of Traditional Chinese MedicineDepartment of Gastroenterology, The Second Affiliated Hospital of Anhui University of Traditional Chinese MedicineThe First Clinical Medical College, Anhui University of Traditional Chinese MedicineThe First Clinical Medical College, Nanjing Medical UniversityThe First Clinical Medical College, Anhui University of Traditional Chinese MedicineThe First Clinical Medical College, Anhui University of Traditional Chinese MedicineDepartment of Gastroenterology, The Second Affiliated Hospital of Anhui University of Traditional Chinese MedicineDepartment of Gastroenterology, The Second Affiliated Hospital of Anhui University of Traditional Chinese MedicineAbstract Objective This study aimed to investigate the diagnostic potential of serum CXC chemokine ligand 5 (CXCL5) in patients with chronic atrophic gastritis (CAG) and to establish a prediction model for better diagnosis of CAG. Methods A retrospective analysis was conducted, encompassing 570 cases of CAG patients admitted to the Department of Gastroenterology of the Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, who underwent gastroscopy and received pathologically confirmed diagnoses between June 2018 and June 2023. Additionally, 570 cases without CAG who underwent health checkups were included and classified into the control group. Single-factor and multi-factorial logistic regression analyses were employed to identify risk factors of CAG, and a prediction model for diagnosing CAG was developed using R software. The predictive performance of the constructed model was verified and evaluated through ROC analysis, decision curve analysis (DCA), and prediction efficacy curve. Results Multi-factorial logistic regression analysis revealed that history of smoking, family history of tumurs, Pepsinogen I (PG I), Gastrin 17 (G-17), Helicobacter pylori infection, D-dimer, and CXCL5 were independent risk factors in CAG patients. A nomogram for the diagnosis of CAG was constructed using R software. The ROC curve demonstrated that CXCL5 showed the best predictive efficacy as a single indicator, with an AUC of 0.897, a sensitivity of 0.789, and a specificity of 0.999. Furthermore, the nomogram exhibited an AUC of 0.992, a sensitivity of 0.958, and a specificity of 0.970. Calibration and DCA curves indicated that the predicted values of the nomogram were highly concordant with the observed values, thus demonstrating a high predictive value. Conclusion In this study, we found a correlation between serum CXCL5 level and CAG, and developed a prediction model to assist the clinical diagnosis of CAG.https://doi.org/10.1186/s12885-024-13394-0Chronic atrophic gastritisCXCL5Predictive modelNomogramDiagnostic efficacy |
| spellingShingle | Bei Pei Qin Sun Yi Zhang Ziang Wen Wenjing Ding Kairui Wu Tingting Li Xuejun Li A novel nomogram for predicting the morbidity of chronic atrophic gastritis based on serum CXCL5 levels BMC Cancer Chronic atrophic gastritis CXCL5 Predictive model Nomogram Diagnostic efficacy |
| title | A novel nomogram for predicting the morbidity of chronic atrophic gastritis based on serum CXCL5 levels |
| title_full | A novel nomogram for predicting the morbidity of chronic atrophic gastritis based on serum CXCL5 levels |
| title_fullStr | A novel nomogram for predicting the morbidity of chronic atrophic gastritis based on serum CXCL5 levels |
| title_full_unstemmed | A novel nomogram for predicting the morbidity of chronic atrophic gastritis based on serum CXCL5 levels |
| title_short | A novel nomogram for predicting the morbidity of chronic atrophic gastritis based on serum CXCL5 levels |
| title_sort | novel nomogram for predicting the morbidity of chronic atrophic gastritis based on serum cxcl5 levels |
| topic | Chronic atrophic gastritis CXCL5 Predictive model Nomogram Diagnostic efficacy |
| url | https://doi.org/10.1186/s12885-024-13394-0 |
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