Colorimetric Visualization of Chirality: From Molecular Sensors to Hierarchical Extension
The optical sensing of chirality is widely used in many fields, such as pharmaceuticals, agriculture, food, and environmental materials. In this context, the color-based cascade amplification of chirality, coupled with chiral recognition for analytes, provides a low-cost and straightforward detectio...
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MDPI AG
2025-04-01
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| Series: | Molecules |
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| author | Yuji Kubo |
| author_facet | Yuji Kubo |
| author_sort | Yuji Kubo |
| collection | DOAJ |
| description | The optical sensing of chirality is widely used in many fields, such as pharmaceuticals, agriculture, food, and environmental materials. In this context, the color-based cascade amplification of chirality, coupled with chiral recognition for analytes, provides a low-cost and straightforward detection method that avoids the use of expensive and sophisticated instrumentation. However, the realization of chiral detection using this approach is still challenging because the construction of a three-dimensional optical recognition site is required to easily discern differences in chirality. Therefore, considerable efforts have been dedicated to developing a hierarchical approach based on molecular organization to provide colorimetric sensors for chirality detection. This review covers function-integrated molecular sensors with colorimetric responsive sites based on absorption, fluorescence, and aggregation-induced emission enabled by molecular organization. In line with the hierarchical approach, data-driven chemometrics is a useful method for quantitative and accurate chiral pattern recognition. Finally, colorimetric nanomaterials are discussed, focusing on sensing platforms using noble-metal nanoparticles, carbon dots, and photonic crystal gels. |
| format | Article |
| id | doaj-art-2844dd01f90f4a6c8a516b77ae2253ef |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-2844dd01f90f4a6c8a516b77ae2253ef2025-08-20T03:13:48ZengMDPI AGMolecules1420-30492025-04-01308174810.3390/molecules30081748Colorimetric Visualization of Chirality: From Molecular Sensors to Hierarchical ExtensionYuji Kubo0Department of Applied Chemistry, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji, Tokyo 192-0397, JapanThe optical sensing of chirality is widely used in many fields, such as pharmaceuticals, agriculture, food, and environmental materials. In this context, the color-based cascade amplification of chirality, coupled with chiral recognition for analytes, provides a low-cost and straightforward detection method that avoids the use of expensive and sophisticated instrumentation. However, the realization of chiral detection using this approach is still challenging because the construction of a three-dimensional optical recognition site is required to easily discern differences in chirality. Therefore, considerable efforts have been dedicated to developing a hierarchical approach based on molecular organization to provide colorimetric sensors for chirality detection. This review covers function-integrated molecular sensors with colorimetric responsive sites based on absorption, fluorescence, and aggregation-induced emission enabled by molecular organization. In line with the hierarchical approach, data-driven chemometrics is a useful method for quantitative and accurate chiral pattern recognition. Finally, colorimetric nanomaterials are discussed, focusing on sensing platforms using noble-metal nanoparticles, carbon dots, and photonic crystal gels.https://www.mdpi.com/1420-3049/30/8/1748colorimetric chiral sensingmolecular organizationchemometricshelical polymernanoprobe |
| spellingShingle | Yuji Kubo Colorimetric Visualization of Chirality: From Molecular Sensors to Hierarchical Extension Molecules colorimetric chiral sensing molecular organization chemometrics helical polymer nanoprobe |
| title | Colorimetric Visualization of Chirality: From Molecular Sensors to Hierarchical Extension |
| title_full | Colorimetric Visualization of Chirality: From Molecular Sensors to Hierarchical Extension |
| title_fullStr | Colorimetric Visualization of Chirality: From Molecular Sensors to Hierarchical Extension |
| title_full_unstemmed | Colorimetric Visualization of Chirality: From Molecular Sensors to Hierarchical Extension |
| title_short | Colorimetric Visualization of Chirality: From Molecular Sensors to Hierarchical Extension |
| title_sort | colorimetric visualization of chirality from molecular sensors to hierarchical extension |
| topic | colorimetric chiral sensing molecular organization chemometrics helical polymer nanoprobe |
| url | https://www.mdpi.com/1420-3049/30/8/1748 |
| work_keys_str_mv | AT yujikubo colorimetricvisualizationofchiralityfrommolecularsensorstohierarchicalextension |