Identification of Clonorchis sinensis in bronchoalveolar lavage fluid and peripheral blood using next-generation sequencing in a patient with septic shock: a case report and literature review
We present a case report of a 59-year-old male diagnosed with pancreatic cancer with multiple abdominal metastases, in whom metagenomic next-generation sequencing unexpectedly identified Clonorchis sinensis genomic sequences in both bronchoalveolar lavage fluid and peripheral blood specimens. Subseq...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2025.2511133 |
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| author | Weipeng Liu Mengting Su Dongjing Zhang Siqi Liu Yin Zhang Zhengfei Yang |
| author_facet | Weipeng Liu Mengting Su Dongjing Zhang Siqi Liu Yin Zhang Zhengfei Yang |
| author_sort | Weipeng Liu |
| collection | DOAJ |
| description | We present a case report of a 59-year-old male diagnosed with pancreatic cancer with multiple abdominal metastases, in whom metagenomic next-generation sequencing unexpectedly identified Clonorchis sinensis genomic sequences in both bronchoalveolar lavage fluid and peripheral blood specimens. Subsequent examination further confirmed the presence of viable C. sinensis eggs in the stool samples. The findings underscore the prognostic significance of enhanced diagnostic protocols for parasitic infections in oncological cases. This investigation demonstrates the clinical utility of molecular diagnostic approaches and alternative biological specimens for detecting C. sinensis infection. |
| format | Article |
| id | doaj-art-283dd58dbdb84fad8a31abea8e1753fb |
| institution | DOAJ |
| issn | 2222-1751 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-283dd58dbdb84fad8a31abea8e1753fb2025-08-20T03:07:35ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512025-12-0114110.1080/22221751.2025.2511133Identification of Clonorchis sinensis in bronchoalveolar lavage fluid and peripheral blood using next-generation sequencing in a patient with septic shock: a case report and literature reviewWeipeng Liu0Mengting Su1Dongjing Zhang2Siqi Liu3Yin Zhang4Zhengfei Yang5Department of Emergency Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaCellular & Molecular Diagnostics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaChinese Atomic Energy Agency Centre of Excellence on Nuclear Technology Applications for Insect Control, Key Laboratory of Tropical Disease Control of the Ministry of Education, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaDepartment of Emergency Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaCellular & Molecular Diagnostics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaDepartment of Emergency Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaWe present a case report of a 59-year-old male diagnosed with pancreatic cancer with multiple abdominal metastases, in whom metagenomic next-generation sequencing unexpectedly identified Clonorchis sinensis genomic sequences in both bronchoalveolar lavage fluid and peripheral blood specimens. Subsequent examination further confirmed the presence of viable C. sinensis eggs in the stool samples. The findings underscore the prognostic significance of enhanced diagnostic protocols for parasitic infections in oncological cases. This investigation demonstrates the clinical utility of molecular diagnostic approaches and alternative biological specimens for detecting C. sinensis infection.https://www.tandfonline.com/doi/10.1080/22221751.2025.2511133Clonorchis sinensisnext-generation sequencingpancreatic cancerar lavage fluidperiphera blood |
| spellingShingle | Weipeng Liu Mengting Su Dongjing Zhang Siqi Liu Yin Zhang Zhengfei Yang Identification of Clonorchis sinensis in bronchoalveolar lavage fluid and peripheral blood using next-generation sequencing in a patient with septic shock: a case report and literature review Emerging Microbes and Infections Clonorchis sinensis next-generation sequencing pancreatic cancer ar lavage fluid periphera blood |
| title | Identification of Clonorchis sinensis in bronchoalveolar lavage fluid and peripheral blood using next-generation sequencing in a patient with septic shock: a case report and literature review |
| title_full | Identification of Clonorchis sinensis in bronchoalveolar lavage fluid and peripheral blood using next-generation sequencing in a patient with septic shock: a case report and literature review |
| title_fullStr | Identification of Clonorchis sinensis in bronchoalveolar lavage fluid and peripheral blood using next-generation sequencing in a patient with septic shock: a case report and literature review |
| title_full_unstemmed | Identification of Clonorchis sinensis in bronchoalveolar lavage fluid and peripheral blood using next-generation sequencing in a patient with septic shock: a case report and literature review |
| title_short | Identification of Clonorchis sinensis in bronchoalveolar lavage fluid and peripheral blood using next-generation sequencing in a patient with septic shock: a case report and literature review |
| title_sort | identification of clonorchis sinensis in bronchoalveolar lavage fluid and peripheral blood using next generation sequencing in a patient with septic shock a case report and literature review |
| topic | Clonorchis sinensis next-generation sequencing pancreatic cancer ar lavage fluid periphera blood |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2025.2511133 |
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