Isolated central nervous system relapse in a child with non- Hodgkin lymphoma during treatment
Isolated central nervous system (CNS) relapse of non-Hodgkin lymphoma (NHL) is very rare. We report a five-year-old boy with T-cell lymphoblastic lymphoma (T-LBL), who developed CNS relapse under treatment when the primary tumor was in complete remission. The patient presented initially with...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2014-02-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/1320 |
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| author | Rejin Kebudi Gülen Tüysüz Öner Doğan Nihal Özdemir |
| author_facet | Rejin Kebudi Gülen Tüysüz Öner Doğan Nihal Özdemir |
| author_sort | Rejin Kebudi |
| collection | DOAJ |
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Isolated central nervous system (CNS) relapse of non-Hodgkin lymphoma (NHL) is very rare. We report a five-year-old boy with T-cell lymphoblastic lymphoma (T-LBL), who developed CNS relapse under treatment when the primary tumor was in complete remission. The patient presented initially with persistent cough and an anterior mediastinal mass and had no bone marrow or CNS involvement at diagnosis. During re-induction treatment, a routine lumbar puncture revealed blasts in the cerebrospinal fluid (CSF). The patient developed neurological signs and symptoms consequently. Craniospinal radiotherapy followed by BFM (Berlin-Frankfurt-Münster) high-risk chemotherapy protocol was initiated. Despite complete response after three courses, the patient experienced CNS relapse and expired due to disease progression. In the treatment of a NHL patient, routine CSF analysis should be done for tumor cells even when the primary disease is in complete remission.
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| format | Article |
| id | doaj-art-283aa7de577a428eb140fe9db1ee0ca7 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2014-02-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-283aa7de577a428eb140fe9db1ee0ca72025-08-20T02:01:53ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212014-02-01561Isolated central nervous system relapse in a child with non- Hodgkin lymphoma during treatmentRejin Kebudi0Gülen TüysüzÖner DoğanNihal ÖzdemirDepartment of Pediatric Hematology-Oncology, Institute of Oncology, İstanbul University Cerrahpaşa Faculty of Medicine, İstanbul, Turkey. gulentuysuz@hotmail.com. Isolated central nervous system (CNS) relapse of non-Hodgkin lymphoma (NHL) is very rare. We report a five-year-old boy with T-cell lymphoblastic lymphoma (T-LBL), who developed CNS relapse under treatment when the primary tumor was in complete remission. The patient presented initially with persistent cough and an anterior mediastinal mass and had no bone marrow or CNS involvement at diagnosis. During re-induction treatment, a routine lumbar puncture revealed blasts in the cerebrospinal fluid (CSF). The patient developed neurological signs and symptoms consequently. Craniospinal radiotherapy followed by BFM (Berlin-Frankfurt-Münster) high-risk chemotherapy protocol was initiated. Despite complete response after three courses, the patient experienced CNS relapse and expired due to disease progression. In the treatment of a NHL patient, routine CSF analysis should be done for tumor cells even when the primary disease is in complete remission. https://turkjpediatr.org/article/view/1320 |
| spellingShingle | Rejin Kebudi Gülen Tüysüz Öner Doğan Nihal Özdemir Isolated central nervous system relapse in a child with non- Hodgkin lymphoma during treatment The Turkish Journal of Pediatrics |
| title | Isolated central nervous system relapse in a child with non- Hodgkin lymphoma during treatment |
| title_full | Isolated central nervous system relapse in a child with non- Hodgkin lymphoma during treatment |
| title_fullStr | Isolated central nervous system relapse in a child with non- Hodgkin lymphoma during treatment |
| title_full_unstemmed | Isolated central nervous system relapse in a child with non- Hodgkin lymphoma during treatment |
| title_short | Isolated central nervous system relapse in a child with non- Hodgkin lymphoma during treatment |
| title_sort | isolated central nervous system relapse in a child with non hodgkin lymphoma during treatment |
| url | https://turkjpediatr.org/article/view/1320 |
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