Evaluation of Cholinergic Deficiency in Preclinical Alzheimer’s Disease Using Pupillometry
Cortical cholinergic deficiency is prominent in Alzheimer’s disease (AD), and published findings of diminished pupil flash response in AD suggest that this deficiency may extend to the visual cortical areas and anterior eye. Pupillometry is a low-cost, noninvasive technique that may be useful for mo...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2017/7935406 |
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| author | Shaun Frost Liam Robinson Christopher C. Rowe David Ames Colin L. Masters Kevin Taddei Stephanie R. Rainey-Smith Ralph N. Martins Yogesan Kanagasingam |
| author_facet | Shaun Frost Liam Robinson Christopher C. Rowe David Ames Colin L. Masters Kevin Taddei Stephanie R. Rainey-Smith Ralph N. Martins Yogesan Kanagasingam |
| author_sort | Shaun Frost |
| collection | DOAJ |
| description | Cortical cholinergic deficiency is prominent in Alzheimer’s disease (AD), and published findings of diminished pupil flash response in AD suggest that this deficiency may extend to the visual cortical areas and anterior eye. Pupillometry is a low-cost, noninvasive technique that may be useful for monitoring cholinergic deficits which generally lead to memory and cognitive disorders. The aim of the study was to evaluate pupillometry for early detection of AD by comparing the pupil flash response (PFR) in AD (N=14) and cognitively normal healthy control (HC, N=115) participants, with the HC group stratified according to high (N=38) and low (N=77) neocortical amyloid burden (NAB). Constriction phase PFR parameters were significantly reduced in AD compared to HC (maximum acceleration p<0.05, maximum velocity p<0.0005, average velocity p<0.005, and constriction amplitude p<0.00005). The high-NAB HC subgroup had reduced PFR response cross-sectionally, and also a greater decline longitudinally, compared to the low-NAB subgroup, suggesting changes to pupil response in preclinical AD. The results suggest that PFR changes may occur in the preclinical phase of AD. Hence, pupillometry has a potential as an adjunct for noninvasive, cost-effective screening for preclinical AD. |
| format | Article |
| id | doaj-art-282f585677e24b2ea08b2a4684f98cf5 |
| institution | OA Journals |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-282f585677e24b2ea08b2a4684f98cf52025-08-20T02:04:17ZengWileyJournal of Ophthalmology2090-004X2090-00582017-01-01201710.1155/2017/79354067935406Evaluation of Cholinergic Deficiency in Preclinical Alzheimer’s Disease Using PupillometryShaun Frost0Liam Robinson1Christopher C. Rowe2David Ames3Colin L. Masters4Kevin Taddei5Stephanie R. Rainey-Smith6Ralph N. Martins7Yogesan Kanagasingam8Commonwealth Scientific and Industrial Research Organisation (CSIRO), Perth, WA, AustraliaCommonwealth Scientific and Industrial Research Organisation (CSIRO), Perth, WA, AustraliaDepartment of Nuclear Medicine and Centre for PET, Austin Health, Melbourne, VIC, AustraliaDepartment of Psychiatry, University of Melbourne, Melbourne, VIC, AustraliaThe Mental Health Research Institute (MHRI), University of Melbourne, Melbourne, VIC, AustraliaSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, AustraliaSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, AustraliaSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, AustraliaCommonwealth Scientific and Industrial Research Organisation (CSIRO), Perth, WA, AustraliaCortical cholinergic deficiency is prominent in Alzheimer’s disease (AD), and published findings of diminished pupil flash response in AD suggest that this deficiency may extend to the visual cortical areas and anterior eye. Pupillometry is a low-cost, noninvasive technique that may be useful for monitoring cholinergic deficits which generally lead to memory and cognitive disorders. The aim of the study was to evaluate pupillometry for early detection of AD by comparing the pupil flash response (PFR) in AD (N=14) and cognitively normal healthy control (HC, N=115) participants, with the HC group stratified according to high (N=38) and low (N=77) neocortical amyloid burden (NAB). Constriction phase PFR parameters were significantly reduced in AD compared to HC (maximum acceleration p<0.05, maximum velocity p<0.0005, average velocity p<0.005, and constriction amplitude p<0.00005). The high-NAB HC subgroup had reduced PFR response cross-sectionally, and also a greater decline longitudinally, compared to the low-NAB subgroup, suggesting changes to pupil response in preclinical AD. The results suggest that PFR changes may occur in the preclinical phase of AD. Hence, pupillometry has a potential as an adjunct for noninvasive, cost-effective screening for preclinical AD.http://dx.doi.org/10.1155/2017/7935406 |
| spellingShingle | Shaun Frost Liam Robinson Christopher C. Rowe David Ames Colin L. Masters Kevin Taddei Stephanie R. Rainey-Smith Ralph N. Martins Yogesan Kanagasingam Evaluation of Cholinergic Deficiency in Preclinical Alzheimer’s Disease Using Pupillometry Journal of Ophthalmology |
| title | Evaluation of Cholinergic Deficiency in Preclinical Alzheimer’s Disease Using Pupillometry |
| title_full | Evaluation of Cholinergic Deficiency in Preclinical Alzheimer’s Disease Using Pupillometry |
| title_fullStr | Evaluation of Cholinergic Deficiency in Preclinical Alzheimer’s Disease Using Pupillometry |
| title_full_unstemmed | Evaluation of Cholinergic Deficiency in Preclinical Alzheimer’s Disease Using Pupillometry |
| title_short | Evaluation of Cholinergic Deficiency in Preclinical Alzheimer’s Disease Using Pupillometry |
| title_sort | evaluation of cholinergic deficiency in preclinical alzheimer s disease using pupillometry |
| url | http://dx.doi.org/10.1155/2017/7935406 |
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