Effect of Th17 and Treg Axis Disorder on Outcomes of Pulmonary Arterial Hypertension in Connective Tissue Diseases
This prospective cohort study is to verify the hypothesis that the balance of Th17 and Treg cells frequencies in the peripheral circulation is disturbed in patients with varying degrees of connective tissue diseases-associated pulmonary arterial hypertension (CTD-aPAH) and to prove the influence of...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/247372 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850229301537931264 |
|---|---|
| author | Saren Gaowa Wenyong Zhou Lilei Yu Xiaohui Zhou Kai Liao Kang Yang Zhibin Lu Hong Jiang Xiaofeng Chen |
| author_facet | Saren Gaowa Wenyong Zhou Lilei Yu Xiaohui Zhou Kai Liao Kang Yang Zhibin Lu Hong Jiang Xiaofeng Chen |
| author_sort | Saren Gaowa |
| collection | DOAJ |
| description | This prospective cohort study is to verify the hypothesis that the balance of Th17 and Treg cells frequencies in the peripheral circulation is disturbed in patients with varying degrees of connective tissue diseases-associated pulmonary arterial hypertension (CTD-aPAH) and to prove the influence of Th17/Treg imbalance on prognosis. We detected the frequencies and absolute counts of Th17 and Treg cells and related serum cytokines secretion and expressions of key transcription factors in 117 patients with connective tissue diseases (CTD), 53 patients with CTD-aPAH, and 48 healthy volunteers. Moreover, the median value according to levels of Th17/Treg ratios in patients with CTD-aPAH was chosen as basis of group division for survival analysis. CTD-aPAH patients revealed significant increase in peripheral Th17 cells, Th17-related cytokines, and ROR γt mRNA levels. They also presented a significant decrease in Treg cells, Treg-related cytokines, and Foxp3 mRNA levels as compared with CTD patients and healthy controls. More importantly, the Th17/Treg ratio was significantly related to the severity and prognosis of CTD-aPAH. This study indicated that the Th17/Treg axis disorder plays a critical role in CTD-aPAH. Furthermore, the dynamic balance between Th17 and Treg cells was likely to influence prognosis of patients with CTD-aPAH. |
| format | Article |
| id | doaj-art-282aecc1e8a7415a8dac49fb6ed44a35 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-282aecc1e8a7415a8dac49fb6ed44a352025-08-20T02:04:17ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/247372247372Effect of Th17 and Treg Axis Disorder on Outcomes of Pulmonary Arterial Hypertension in Connective Tissue DiseasesSaren Gaowa0Wenyong Zhou1Lilei Yu2Xiaohui Zhou3Kai Liao4Kang Yang5Zhibin Lu6Hong Jiang7Xiaofeng Chen8Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaDepartment of Cardiothoracic Surgery, East Hospital, Tongji University, Shanghai 200120, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaDepartment of Cardiothoracic Surgery, East Hospital, Tongji University, Shanghai 200120, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaDepartment of Cardiothoracic Surgery, Huashan Hospital, Fudan University, Shanghai 200040, ChinaThis prospective cohort study is to verify the hypothesis that the balance of Th17 and Treg cells frequencies in the peripheral circulation is disturbed in patients with varying degrees of connective tissue diseases-associated pulmonary arterial hypertension (CTD-aPAH) and to prove the influence of Th17/Treg imbalance on prognosis. We detected the frequencies and absolute counts of Th17 and Treg cells and related serum cytokines secretion and expressions of key transcription factors in 117 patients with connective tissue diseases (CTD), 53 patients with CTD-aPAH, and 48 healthy volunteers. Moreover, the median value according to levels of Th17/Treg ratios in patients with CTD-aPAH was chosen as basis of group division for survival analysis. CTD-aPAH patients revealed significant increase in peripheral Th17 cells, Th17-related cytokines, and ROR γt mRNA levels. They also presented a significant decrease in Treg cells, Treg-related cytokines, and Foxp3 mRNA levels as compared with CTD patients and healthy controls. More importantly, the Th17/Treg ratio was significantly related to the severity and prognosis of CTD-aPAH. This study indicated that the Th17/Treg axis disorder plays a critical role in CTD-aPAH. Furthermore, the dynamic balance between Th17 and Treg cells was likely to influence prognosis of patients with CTD-aPAH.http://dx.doi.org/10.1155/2014/247372 |
| spellingShingle | Saren Gaowa Wenyong Zhou Lilei Yu Xiaohui Zhou Kai Liao Kang Yang Zhibin Lu Hong Jiang Xiaofeng Chen Effect of Th17 and Treg Axis Disorder on Outcomes of Pulmonary Arterial Hypertension in Connective Tissue Diseases Mediators of Inflammation |
| title | Effect of Th17 and Treg Axis Disorder on Outcomes of Pulmonary Arterial Hypertension in Connective Tissue Diseases |
| title_full | Effect of Th17 and Treg Axis Disorder on Outcomes of Pulmonary Arterial Hypertension in Connective Tissue Diseases |
| title_fullStr | Effect of Th17 and Treg Axis Disorder on Outcomes of Pulmonary Arterial Hypertension in Connective Tissue Diseases |
| title_full_unstemmed | Effect of Th17 and Treg Axis Disorder on Outcomes of Pulmonary Arterial Hypertension in Connective Tissue Diseases |
| title_short | Effect of Th17 and Treg Axis Disorder on Outcomes of Pulmonary Arterial Hypertension in Connective Tissue Diseases |
| title_sort | effect of th17 and treg axis disorder on outcomes of pulmonary arterial hypertension in connective tissue diseases |
| url | http://dx.doi.org/10.1155/2014/247372 |
| work_keys_str_mv | AT sarengaowa effectofth17andtregaxisdisorderonoutcomesofpulmonaryarterialhypertensioninconnectivetissuediseases AT wenyongzhou effectofth17andtregaxisdisorderonoutcomesofpulmonaryarterialhypertensioninconnectivetissuediseases AT lileiyu effectofth17andtregaxisdisorderonoutcomesofpulmonaryarterialhypertensioninconnectivetissuediseases AT xiaohuizhou effectofth17andtregaxisdisorderonoutcomesofpulmonaryarterialhypertensioninconnectivetissuediseases AT kailiao effectofth17andtregaxisdisorderonoutcomesofpulmonaryarterialhypertensioninconnectivetissuediseases AT kangyang effectofth17andtregaxisdisorderonoutcomesofpulmonaryarterialhypertensioninconnectivetissuediseases AT zhibinlu effectofth17andtregaxisdisorderonoutcomesofpulmonaryarterialhypertensioninconnectivetissuediseases AT hongjiang effectofth17andtregaxisdisorderonoutcomesofpulmonaryarterialhypertensioninconnectivetissuediseases AT xiaofengchen effectofth17andtregaxisdisorderonoutcomesofpulmonaryarterialhypertensioninconnectivetissuediseases |