Preventive treatment effects on brain structures and functions in patients with chronic migraine: A multimodel magnetic resonance imaging study
Abstract Patients with chronic migraine (CM) often exhibit structural and functional alterations in pain‐matrix regions, but it remains unclear how preventive treatment affects these changes. Therefore, this study aimed to investigate the structural and functional changes in pain‐matrix regions in C...
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Wiley
2024-12-01
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| Series: | Kaohsiung Journal of Medical Sciences |
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| Online Access: | https://doi.org/10.1002/kjm2.12903 |
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| author | Tai‐Yuan Chen Ching‐Chung Ko Poh‐Shiow Yeh Te‐Chang Wu Yun‐Ju Shih Chun‐Ming Yang Ju‐Chi Lee Ming‐Chung Chou Kao‐Chang Lin |
| author_facet | Tai‐Yuan Chen Ching‐Chung Ko Poh‐Shiow Yeh Te‐Chang Wu Yun‐Ju Shih Chun‐Ming Yang Ju‐Chi Lee Ming‐Chung Chou Kao‐Chang Lin |
| author_sort | Tai‐Yuan Chen |
| collection | DOAJ |
| description | Abstract Patients with chronic migraine (CM) often exhibit structural and functional alterations in pain‐matrix regions, but it remains unclear how preventive treatment affects these changes. Therefore, this study aimed to investigate the structural and functional changes in pain‐matrix regions in CM patients after 6‐month treatment. A total of 24 patients with CM and 15 healthy controls were recruited for this study. Patients were divided into responder group (N = 9) and non‐responder group (N = 15). After completing the Migraine Disability Assessment (MIDAS) questionnaire, all patients underwent whole‐brain high‐resolution T1‐weighted images, diffusion‐weighted imaging, and resting‐state functional magnetic resonance imaging at baseline and 6‐month follow‐up. Whole brain gray matter volume and white matter diffusion indices were analyzed using voxel‐based analysis. Structural and functional connectivity analyses were performed to understand brain changes in patients after 6‐month preventive treatment. The responder group exhibited significantly higher MIDAS scores than the non‐responder group at baseline, but no significant difference between the two groups at follow‐up. No significant interval change was noted in gray matter volume, white matter diffusion indices, and structural connectivity in CM patients after 6‐month treatment. Nonetheless, the functional connectivity was significantly increased between occipital, temporal lobes and cerebellum, and was significantly decreased between parietal and temporal lobes after 6‐month preventive treatment. We concluded that resting‐state functional connectivity was suitable for investigating the preventive treatment effect on CM patients. |
| format | Article |
| id | doaj-art-282683bc2e60426d8a613d202d44e1f4 |
| institution | OA Journals |
| issn | 1607-551X 2410-8650 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj-art-282683bc2e60426d8a613d202d44e1f42025-08-20T02:30:50ZengWileyKaohsiung Journal of Medical Sciences1607-551X2410-86502024-12-0140121077108510.1002/kjm2.12903Preventive treatment effects on brain structures and functions in patients with chronic migraine: A multimodel magnetic resonance imaging studyTai‐Yuan Chen0Ching‐Chung Ko1Poh‐Shiow Yeh2Te‐Chang Wu3Yun‐Ju Shih4Chun‐Ming Yang5Ju‐Chi Lee6Ming‐Chung Chou7Kao‐Chang Lin8Department of Radiology Chi Mei Medical Center Tainan TaiwanDepartment of Radiology Chi Mei Medical Center Tainan TaiwanDepartment of Neurology Chi Mei Medical Center Tainan TaiwanDepartment of Radiology Chi Mei Medical Center Tainan TaiwanDepartment of Radiology Chi Mei Medical Center Tainan TaiwanDepartment of Neurology Chi Mei Medical Center Tainan TaiwanDepartment of Neurology Chi Mei Medical Center Tainan TaiwanDepartment of Medical Imaging and Radiological Sciences Kaohsiung Medical University Kaohsiung TaiwanDepartment of Neurology and Holistic Care Chi Mei Medical Center Tainan TaiwanAbstract Patients with chronic migraine (CM) often exhibit structural and functional alterations in pain‐matrix regions, but it remains unclear how preventive treatment affects these changes. Therefore, this study aimed to investigate the structural and functional changes in pain‐matrix regions in CM patients after 6‐month treatment. A total of 24 patients with CM and 15 healthy controls were recruited for this study. Patients were divided into responder group (N = 9) and non‐responder group (N = 15). After completing the Migraine Disability Assessment (MIDAS) questionnaire, all patients underwent whole‐brain high‐resolution T1‐weighted images, diffusion‐weighted imaging, and resting‐state functional magnetic resonance imaging at baseline and 6‐month follow‐up. Whole brain gray matter volume and white matter diffusion indices were analyzed using voxel‐based analysis. Structural and functional connectivity analyses were performed to understand brain changes in patients after 6‐month preventive treatment. The responder group exhibited significantly higher MIDAS scores than the non‐responder group at baseline, but no significant difference between the two groups at follow‐up. No significant interval change was noted in gray matter volume, white matter diffusion indices, and structural connectivity in CM patients after 6‐month treatment. Nonetheless, the functional connectivity was significantly increased between occipital, temporal lobes and cerebellum, and was significantly decreased between parietal and temporal lobes after 6‐month preventive treatment. We concluded that resting‐state functional connectivity was suitable for investigating the preventive treatment effect on CM patients.https://doi.org/10.1002/kjm2.12903functional connectivityfunctional MRImigrainepain‐matrix networkstructural connectivity |
| spellingShingle | Tai‐Yuan Chen Ching‐Chung Ko Poh‐Shiow Yeh Te‐Chang Wu Yun‐Ju Shih Chun‐Ming Yang Ju‐Chi Lee Ming‐Chung Chou Kao‐Chang Lin Preventive treatment effects on brain structures and functions in patients with chronic migraine: A multimodel magnetic resonance imaging study Kaohsiung Journal of Medical Sciences functional connectivity functional MRI migraine pain‐matrix network structural connectivity |
| title | Preventive treatment effects on brain structures and functions in patients with chronic migraine: A multimodel magnetic resonance imaging study |
| title_full | Preventive treatment effects on brain structures and functions in patients with chronic migraine: A multimodel magnetic resonance imaging study |
| title_fullStr | Preventive treatment effects on brain structures and functions in patients with chronic migraine: A multimodel magnetic resonance imaging study |
| title_full_unstemmed | Preventive treatment effects on brain structures and functions in patients with chronic migraine: A multimodel magnetic resonance imaging study |
| title_short | Preventive treatment effects on brain structures and functions in patients with chronic migraine: A multimodel magnetic resonance imaging study |
| title_sort | preventive treatment effects on brain structures and functions in patients with chronic migraine a multimodel magnetic resonance imaging study |
| topic | functional connectivity functional MRI migraine pain‐matrix network structural connectivity |
| url | https://doi.org/10.1002/kjm2.12903 |
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