Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker
Head and neck squamous cell carcinoma (HNSCC) is a type of tumour with a relatively poor prognosis. In recent years, immune checkpoint inhibitors, such as CTLA-4 and PD-1/PDL-1 inhibitors, have improved the treatment status of advanced tumours. However, the emergence of drug resistance has brought d...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Applied Bionics and Biomechanics |
| Online Access: | http://dx.doi.org/10.1155/2022/3051907 |
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| author | Yaoting Zhang Sultan Kadasah Jiaheng Xie Dongsheng Gu |
| author_facet | Yaoting Zhang Sultan Kadasah Jiaheng Xie Dongsheng Gu |
| author_sort | Yaoting Zhang |
| collection | DOAJ |
| description | Head and neck squamous cell carcinoma (HNSCC) is a type of tumour with a relatively poor prognosis. In recent years, immune checkpoint inhibitors, such as CTLA-4 and PD-1/PDL-1 inhibitors, have improved the treatment status of advanced tumours. However, the emergence of drug resistance has brought difficulties to clinical treatment, and new immune checkpoint research is imminent. The hypoxia-adenosine pathway, in which CD73 encoded by the NT5E gene is a key enzyme for adenosine production, has been identified as an immune checkpoint of great potential. Therefore, NT5E may play an important role in HNSCC. We performed a detailed bioinformatics analysis of NT5E in HNSCC, and the results showed that the overexpression of NT5E in HNSCC was associated with poor prognosis. Our further investigation of the coexpression pattern of HNSCC could provide a reference for drug resistance and immunotherapy studies. |
| format | Article |
| id | doaj-art-28261b450a794d26b711443c4a5cc8bb |
| institution | Kabale University |
| issn | 1754-2103 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Applied Bionics and Biomechanics |
| spelling | doaj-art-28261b450a794d26b711443c4a5cc8bb2025-02-03T05:50:32ZengWileyApplied Bionics and Biomechanics1754-21032022-01-01202210.1155/2022/3051907Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic BiomarkerYaoting Zhang0Sultan Kadasah1Jiaheng Xie2Dongsheng Gu3Department of Otorhinolaryngology-Head and Neck SurgeryDepartment of BiologyDepartment of Burn and Plastic SurgeryDepartment of Otorhinolaryngology-Head and Neck SurgeryHead and neck squamous cell carcinoma (HNSCC) is a type of tumour with a relatively poor prognosis. In recent years, immune checkpoint inhibitors, such as CTLA-4 and PD-1/PDL-1 inhibitors, have improved the treatment status of advanced tumours. However, the emergence of drug resistance has brought difficulties to clinical treatment, and new immune checkpoint research is imminent. The hypoxia-adenosine pathway, in which CD73 encoded by the NT5E gene is a key enzyme for adenosine production, has been identified as an immune checkpoint of great potential. Therefore, NT5E may play an important role in HNSCC. We performed a detailed bioinformatics analysis of NT5E in HNSCC, and the results showed that the overexpression of NT5E in HNSCC was associated with poor prognosis. Our further investigation of the coexpression pattern of HNSCC could provide a reference for drug resistance and immunotherapy studies.http://dx.doi.org/10.1155/2022/3051907 |
| spellingShingle | Yaoting Zhang Sultan Kadasah Jiaheng Xie Dongsheng Gu Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker Applied Bionics and Biomechanics |
| title | Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker |
| title_full | Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker |
| title_fullStr | Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker |
| title_full_unstemmed | Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker |
| title_short | Head and Neck Squamous Cell Carcinoma: NT5E Could Be a Prognostic Biomarker |
| title_sort | head and neck squamous cell carcinoma nt5e could be a prognostic biomarker |
| url | http://dx.doi.org/10.1155/2022/3051907 |
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