Cancer treatment comes to age: from one-size-fits-all to next-generation sequencing (NGS) technologies
Cancer is one of the leading causes of death worldwide and one of the greatest challenges in extending life expectancy. The paradigm of one-size-fits-all medicine has already given way to the stratification of patients by disease subtypes, clinical characteristics, and biomarkers (stratified medicin...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2024-07-01
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| Series: | BioImpacts |
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| Online Access: | https://bi.tbzmed.ac.ir/PDF/bi-14-29957.pdf |
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| author | Sepideh Parvizpour Hanieh Beyrampour-Basmenj Jafar Razmara Farhad Farhadi Mohd Shahir Shamsir |
| author_facet | Sepideh Parvizpour Hanieh Beyrampour-Basmenj Jafar Razmara Farhad Farhadi Mohd Shahir Shamsir |
| author_sort | Sepideh Parvizpour |
| collection | DOAJ |
| description | Cancer is one of the leading causes of death worldwide and one of the greatest challenges in extending life expectancy. The paradigm of one-size-fits-all medicine has already given way to the stratification of patients by disease subtypes, clinical characteristics, and biomarkers (stratified medicine). The introduction of next-generation sequencing (NGS) in clinical oncology has made it possible to tailor cancer patient therapy to their molecular profiles. NGS is expected to lead the transition to precision medicine (PM), where the right therapeutic approach is chosen for each patient based on their characteristics and mutations. Here, we highlight how the NGS technology facilitates cancer treatment. In this regard, first, precision medicine and NGS technology are reviewed, and then, the NGS revolution in precision medicine is described. In the sequel, the role of NGS in oncology and the existing limitations are discussed. The available databases and bioinformatics tools and online servers used in NGS data analysis are also reviewed. The review ends with concluding remarks. |
| format | Article |
| id | doaj-art-28209cc6e8c64f2aba46eb000217bb32 |
| institution | Kabale University |
| issn | 2228-5652 2228-5660 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | BioImpacts |
| spelling | doaj-art-28209cc6e8c64f2aba46eb000217bb322025-01-18T10:00:12ZengTabriz University of Medical SciencesBioImpacts2228-56522228-56602024-07-01144299572995710.34172/bi.2023.29957bi-29957Cancer treatment comes to age: from one-size-fits-all to next-generation sequencing (NGS) technologiesSepideh Parvizpour0Hanieh Beyrampour-Basmenj1Jafar Razmara2Farhad Farhadi3Mohd Shahir Shamsir4Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Computer Science, Faculty of Mathematics, Statistics and Computer Science, University of Tabriz, Tabriz, IranFood and Drug Administration, Tabriz University of Medical Sciences, Tabriz, IranBioinformatics Research Group, Faculty of Science, Universiti Teknologi Malaysia, Johor Bahru, MalaysiaCancer is one of the leading causes of death worldwide and one of the greatest challenges in extending life expectancy. The paradigm of one-size-fits-all medicine has already given way to the stratification of patients by disease subtypes, clinical characteristics, and biomarkers (stratified medicine). The introduction of next-generation sequencing (NGS) in clinical oncology has made it possible to tailor cancer patient therapy to their molecular profiles. NGS is expected to lead the transition to precision medicine (PM), where the right therapeutic approach is chosen for each patient based on their characteristics and mutations. Here, we highlight how the NGS technology facilitates cancer treatment. In this regard, first, precision medicine and NGS technology are reviewed, and then, the NGS revolution in precision medicine is described. In the sequel, the role of NGS in oncology and the existing limitations are discussed. The available databases and bioinformatics tools and online servers used in NGS data analysis are also reviewed. The review ends with concluding remarks.https://bi.tbzmed.ac.ir/PDF/bi-14-29957.pdfcancernext-generation sequencingone-size-fits-all medicineprecision medicinepersonalized medicinestratified medicine |
| spellingShingle | Sepideh Parvizpour Hanieh Beyrampour-Basmenj Jafar Razmara Farhad Farhadi Mohd Shahir Shamsir Cancer treatment comes to age: from one-size-fits-all to next-generation sequencing (NGS) technologies BioImpacts cancer next-generation sequencing one-size-fits-all medicine precision medicine personalized medicine stratified medicine |
| title | Cancer treatment comes to age: from one-size-fits-all to next-generation sequencing (NGS) technologies |
| title_full | Cancer treatment comes to age: from one-size-fits-all to next-generation sequencing (NGS) technologies |
| title_fullStr | Cancer treatment comes to age: from one-size-fits-all to next-generation sequencing (NGS) technologies |
| title_full_unstemmed | Cancer treatment comes to age: from one-size-fits-all to next-generation sequencing (NGS) technologies |
| title_short | Cancer treatment comes to age: from one-size-fits-all to next-generation sequencing (NGS) technologies |
| title_sort | cancer treatment comes to age from one size fits all to next generation sequencing ngs technologies |
| topic | cancer next-generation sequencing one-size-fits-all medicine precision medicine personalized medicine stratified medicine |
| url | https://bi.tbzmed.ac.ir/PDF/bi-14-29957.pdf |
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