Sinapic acid attenuated nephrotoxicity against Cyclophosphamide in mice model: A histochemical, immunohistochemical and histopathological evaluation

Sinapic acid attenuated nephrotoxicity against Cyclophosphamide in mice model: A histochemical, immunohistochemical and histopathological evaluation

Objective(s): Cyclophosphamide (CP) is a chemotherapeutic drug used to treat various tumors. It causes nephrotoxicity by producing reactive oxygen species. Sinapic acid (SA) exhibits anti-oxidant, antiapoptotic, and anti-inflammatory activities at low doses as a phenylpropanoid. This study aimed to...

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Bibliographic Details
Main Authors: Saeed Raoof, Shiva Rezaei, Mehryar Zargari, Masooreh Mirzaei, Seyed Jalal Hosseinimehr, Abbasali Karimpour Malekshah, Fereshteh Talebpour Amiri
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2025-05-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
caspase-3
cyclophosphamide
nephrotoxicity
nf- kb
oxidative stress
sinapic acid
Online Access:https://ijbms.mums.ac.ir/article_25517_2fd79cc94edce4d6a599e9f50f3a60d4.pdf
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