STUDY OF THE LEVEL OF FATTY ACIDS IN ERYTHROCYTE MEMBRANES AND SERUM OF PATIENTS WITH COLORECTAL CANCER IN NOVOSIBIRSK
The objective is to measure the level of fatty acids in erythrocyte membranes and serum of patients with colorectal cancer.Materials and methods. The study group included 100 patients with diagnosed colorectal cancer (57 men and 43 women). The control group included 24 reasonably healthy people (14...
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ABV-press
2018-07-01
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| Series: | Успехи молекулярной онкологии |
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| Online Access: | https://umo.abvpress.ru/jour/article/view/148 |
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| author | M. V. Kruchinina V. N. Kruchinin Ya. I. Prudnikova A. A. Gromov M. V. Shashkov A. S. Sokolova |
| author_facet | M. V. Kruchinina V. N. Kruchinin Ya. I. Prudnikova A. A. Gromov M. V. Shashkov A. S. Sokolova |
| author_sort | M. V. Kruchinina |
| collection | DOAJ |
| description | The objective is to measure the level of fatty acids in erythrocyte membranes and serum of patients with colorectal cancer.Materials and methods. The study group included 100 patients with diagnosed colorectal cancer (57 men and 43 women). The control group included 24 reasonably healthy people (14 men and 10 women) matched for age and sex, without malignant cancers or manifested pathology of the internal organs.Results. Decreased levels of saturated, monounsaturated fatty acids and increased levels of polyunsaturated fatty acids (PUFAs) in erythrocyte membranes and serum (p <0.0001–0.05) were observed. The levels of omega-3 PUFAs in colorectal cancer exceeded the levels in healthy individuals both in erythrocyte membranes and in serum; for omega-6 PUFAs only a trend was observed. At the same time, the ratio of omega-6/omega-3 PUFAs in colorectal cancer was lower than in control (p <0.0001–0.002). The state of erythrocyte membranes more significantly and for more parameters characterized differences between the groups than serum. The most discriminating parameters between patients with colorectal cancer and healthy individuals both in erythrocyte membranes and serum were the levels of C20:2;11,14 (eicosadienoic), C20:3;8,11,14 (dihomo-γ-linolenic), C20:4;5,8,11,14 (eicosatetraenoic, arachidonic), C22:5;7,10,13,16,19 (docosapentaenoic), and C22:6;4,7,10,13,16,19 (docosahexaenoic) PUFAs. |
| format | Article |
| id | doaj-art-2818fbb1501242debed820db66da9747 |
| institution | DOAJ |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| publishDate | 2018-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj-art-2818fbb1501242debed820db66da97472025-08-20T03:00:55ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872018-07-0152506110.17650/2313-805X-2018-5-2-50-61123STUDY OF THE LEVEL OF FATTY ACIDS IN ERYTHROCYTE MEMBRANES AND SERUM OF PATIENTS WITH COLORECTAL CANCER IN NOVOSIBIRSKM. V. Kruchinina0V. N. Kruchinin1Ya. I. Prudnikova2A. A. Gromov3M. V. Shashkov4A. S. Sokolova5Research Institute of Therapy and Preventive Medicine – a branch of the Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences; Novosibirsk State Medical University, Ministry of Health of RussiaA.V. Rzhanov Institute of Semiconductor Physics of the Siberian Branch of the Russian Academy of SciencesResearch Institute of Therapy and Preventive Medicine – a branch of the Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of SciencesResearch Institute of Therapy and Preventive Medicine – a branch of the Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of SciencesG.K. Boreskov Institute of Catalysis of the Siberian Branch of the Russian Academy of SciencesN.N. Vorozhtsov Novosibirsk Institute of Organic ChemistryThe objective is to measure the level of fatty acids in erythrocyte membranes and serum of patients with colorectal cancer.Materials and methods. The study group included 100 patients with diagnosed colorectal cancer (57 men and 43 women). The control group included 24 reasonably healthy people (14 men and 10 women) matched for age and sex, without malignant cancers or manifested pathology of the internal organs.Results. Decreased levels of saturated, monounsaturated fatty acids and increased levels of polyunsaturated fatty acids (PUFAs) in erythrocyte membranes and serum (p <0.0001–0.05) were observed. The levels of omega-3 PUFAs in colorectal cancer exceeded the levels in healthy individuals both in erythrocyte membranes and in serum; for omega-6 PUFAs only a trend was observed. At the same time, the ratio of omega-6/omega-3 PUFAs in colorectal cancer was lower than in control (p <0.0001–0.002). The state of erythrocyte membranes more significantly and for more parameters characterized differences between the groups than serum. The most discriminating parameters between patients with colorectal cancer and healthy individuals both in erythrocyte membranes and serum were the levels of C20:2;11,14 (eicosadienoic), C20:3;8,11,14 (dihomo-γ-linolenic), C20:4;5,8,11,14 (eicosatetraenoic, arachidonic), C22:5;7,10,13,16,19 (docosapentaenoic), and C22:6;4,7,10,13,16,19 (docosahexaenoic) PUFAs.https://umo.abvpress.ru/jour/article/view/148membrane fatty acidspolyunsaturated fatty acidsserumerythrocytescolorectal cancer |
| spellingShingle | M. V. Kruchinina V. N. Kruchinin Ya. I. Prudnikova A. A. Gromov M. V. Shashkov A. S. Sokolova STUDY OF THE LEVEL OF FATTY ACIDS IN ERYTHROCYTE MEMBRANES AND SERUM OF PATIENTS WITH COLORECTAL CANCER IN NOVOSIBIRSK Успехи молекулярной онкологии membrane fatty acids polyunsaturated fatty acids serum erythrocytes colorectal cancer |
| title | STUDY OF THE LEVEL OF FATTY ACIDS IN ERYTHROCYTE MEMBRANES AND SERUM OF PATIENTS WITH COLORECTAL CANCER IN NOVOSIBIRSK |
| title_full | STUDY OF THE LEVEL OF FATTY ACIDS IN ERYTHROCYTE MEMBRANES AND SERUM OF PATIENTS WITH COLORECTAL CANCER IN NOVOSIBIRSK |
| title_fullStr | STUDY OF THE LEVEL OF FATTY ACIDS IN ERYTHROCYTE MEMBRANES AND SERUM OF PATIENTS WITH COLORECTAL CANCER IN NOVOSIBIRSK |
| title_full_unstemmed | STUDY OF THE LEVEL OF FATTY ACIDS IN ERYTHROCYTE MEMBRANES AND SERUM OF PATIENTS WITH COLORECTAL CANCER IN NOVOSIBIRSK |
| title_short | STUDY OF THE LEVEL OF FATTY ACIDS IN ERYTHROCYTE MEMBRANES AND SERUM OF PATIENTS WITH COLORECTAL CANCER IN NOVOSIBIRSK |
| title_sort | study of the level of fatty acids in erythrocyte membranes and serum of patients with colorectal cancer in novosibirsk |
| topic | membrane fatty acids polyunsaturated fatty acids serum erythrocytes colorectal cancer |
| url | https://umo.abvpress.ru/jour/article/view/148 |
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