Hospitalizations and deaths among people coinfected with HIV and HCV
Abstract Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) remains a significant public health challenge. This retrospective, population-based study assessed the trends in hospitalization rates among patients co-infected with HCV and HIV in Poland in 2012–2022, encompas...
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Nature Portfolio
2024-11-01
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| Online Access: | https://doi.org/10.1038/s41598-024-80289-2 |
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| author | Dorota Zarębska-Michaluk Piotr Rzymski Krzysztof Kanecki Piotr Tyszko Katarzyna Lewtak Paweł Goryński Agnieszka Genowska Miłosz Parczewski Robert Flisiak |
| author_facet | Dorota Zarębska-Michaluk Piotr Rzymski Krzysztof Kanecki Piotr Tyszko Katarzyna Lewtak Paweł Goryński Agnieszka Genowska Miłosz Parczewski Robert Flisiak |
| author_sort | Dorota Zarębska-Michaluk |
| collection | DOAJ |
| description | Abstract Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) remains a significant public health challenge. This retrospective, population-based study assessed the trends in hospitalization rates among patients co-infected with HCV and HIV in Poland in 2012–2022, encompassing the COVID-19 pandemic and massive influx of war refugees from Ukraine, the demographics and clinical characteristics among hospitalized patients, including in-hospital case fatality rates. Most hospitalized patients were over 40 years old (mean ± SD: 41.7 ± 8.9 years) and were men (74%). The mean annual hospitalization rate was estimated at 1.33 per 105 and was three-fold lower in the pandemic period (mean 0.51 per 105) than in the pre-pandemic era (mean 1.63 per 105). In turn, the in-hospital case-fatality rates increased during the pandemic in men (from a mean of 1.83 to 3.93) but not in women (a mean of 1.53 in both periods). There was no significant increase in hospitalization rates in 2022, during which the significant inflow of war refugees in Ukraine occurred. The epidemiological situation of people (co)infected with HIV and HCV in Poland requires further monitoring, though it did not escalate in the studied period due to the influx of war refugees from Ukraine. |
| format | Article |
| id | doaj-art-28178f20ed2140bca75fe38ce6599d51 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-28178f20ed2140bca75fe38ce6599d512025-08-20T02:32:53ZengNature PortfolioScientific Reports2045-23222024-11-011411910.1038/s41598-024-80289-2Hospitalizations and deaths among people coinfected with HIV and HCVDorota Zarębska-Michaluk0Piotr Rzymski1Krzysztof Kanecki2Piotr Tyszko3Katarzyna Lewtak4Paweł Goryński5Agnieszka Genowska6Miłosz Parczewski7Robert Flisiak8Department of Infectious Diseases and Allergology, Jan Kochanowski UniversityDepartment of Environmental Medicine, Poznan University of Medical SciencesDepartment of Social Medicine and Public Health, Medical University of WarsawDepartment of Social Medicine and Public Health, Medical University of WarsawDepartment of Social Medicine and Public Health, Medical University of WarsawNational Institute of Public Health NIH - National Research InstituteDepartment of Public Health, Medical University of BialystokDepartment of Infectious, Tropical Diseases and Immune Deficiency, Pomeranian Medical UniversityDepartment of Infectious Diseases and Hepatology, Medical University of BiałystokAbstract Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) remains a significant public health challenge. This retrospective, population-based study assessed the trends in hospitalization rates among patients co-infected with HCV and HIV in Poland in 2012–2022, encompassing the COVID-19 pandemic and massive influx of war refugees from Ukraine, the demographics and clinical characteristics among hospitalized patients, including in-hospital case fatality rates. Most hospitalized patients were over 40 years old (mean ± SD: 41.7 ± 8.9 years) and were men (74%). The mean annual hospitalization rate was estimated at 1.33 per 105 and was three-fold lower in the pandemic period (mean 0.51 per 105) than in the pre-pandemic era (mean 1.63 per 105). In turn, the in-hospital case-fatality rates increased during the pandemic in men (from a mean of 1.83 to 3.93) but not in women (a mean of 1.53 in both periods). There was no significant increase in hospitalization rates in 2022, during which the significant inflow of war refugees in Ukraine occurred. The epidemiological situation of people (co)infected with HIV and HCV in Poland requires further monitoring, though it did not escalate in the studied period due to the influx of war refugees from Ukraine.https://doi.org/10.1038/s41598-024-80289-2Hepatitis CSexually-transmitted diseaseEpidemiologyCOVID-19 pandemic |
| spellingShingle | Dorota Zarębska-Michaluk Piotr Rzymski Krzysztof Kanecki Piotr Tyszko Katarzyna Lewtak Paweł Goryński Agnieszka Genowska Miłosz Parczewski Robert Flisiak Hospitalizations and deaths among people coinfected with HIV and HCV Scientific Reports Hepatitis C Sexually-transmitted disease Epidemiology COVID-19 pandemic |
| title | Hospitalizations and deaths among people coinfected with HIV and HCV |
| title_full | Hospitalizations and deaths among people coinfected with HIV and HCV |
| title_fullStr | Hospitalizations and deaths among people coinfected with HIV and HCV |
| title_full_unstemmed | Hospitalizations and deaths among people coinfected with HIV and HCV |
| title_short | Hospitalizations and deaths among people coinfected with HIV and HCV |
| title_sort | hospitalizations and deaths among people coinfected with hiv and hcv |
| topic | Hepatitis C Sexually-transmitted disease Epidemiology COVID-19 pandemic |
| url | https://doi.org/10.1038/s41598-024-80289-2 |
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