CircABCA1 promotes ccRCC by reprogramming cholesterol metabolism and facilitating M2 macrophage polarization through IGF2BP3-mediated stabilization of SCARB1 mRNA

CircABCA1 promotes ccRCC by reprogramming cholesterol metabolism and facilitating M2 macrophage polarization through IGF2BP3-mediated stabilization of SCARB1 mRNA

Abstract Background The reliance of clear cell renal cell carcinoma (ccRCC) on exogenous cholesterol import implies a metabolic susceptibility. This susceptibility represents a potential avenue that can be exploited as a novel therapeutic approach for ccRCC. Circular RNAs (circRNAs) are emerging reg...

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Bibliographic Details
Main Authors: Hao Ning, Yan Jiang, Binbin Li, Junwu Ren, Cong Wang, Ling Wei, Linfei Li, Ai Ran, Zuozhang Li, Jiao Li, Wei Li, Yongquan Wang, Bin Xiao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Cancer
Subjects:
CcRCC
CircABCA1
Cholesterol
Ternary complex
Macrophages
Online Access:https://doi.org/10.1186/s12943-025-02398-4
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