Chemotherapy for Metastatic Gastric Cancer
Gastric cancer is the fourth most common malignancy in Korea and remains the fifth and seventh leading cause of cancer death in males and females, respectively. Although the survival rates for gastric cancer have improved, unresectable or metastatic gastric cancer still has an abysmal prognosis, and...
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| Format: | Article |
| Language: | English |
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Jin Publishing & Printing Co.
2025-01-01
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| Series: | The Korean Journal of Gastroenterology |
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| Online Access: | https://www.kjg.or.kr/journal/view.html?uid=6074&vmd=Full |
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| _version_ | 1825206697906405376 |
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| author | Sung Eun Kim Moo In Park Myung Hun Lee |
| author_facet | Sung Eun Kim Moo In Park Myung Hun Lee |
| author_sort | Sung Eun Kim |
| collection | DOAJ |
| description | Gastric cancer is the fourth most common malignancy in Korea and remains the fifth and seventh leading cause of cancer death in males and females, respectively. Although the survival rates for gastric cancer have improved, unresectable or metastatic gastric cancer still has an abysmal prognosis, and the five-year survival rate for patients with stage IV gastric cancer is approximately 6.6% in Korea. The treatment of patients with unresectable or metastatic gastric cancer is based on chemotherapy. A combination of fluoropyrimidine and platinum is the most widely used first-line treatment for gastric cancer worldwide. In recent decades, a better understanding of cancer biology has led to targeted therapies becoming the treatment paradigm for many cancers, including gastric cancer. In addition, immunotherapies have also been reported to improve survival in several cancers, particularly in patients with unresectable or metastatic gastric cancer who have failed multiple lines of chemotherapy. This review evaluates landmark studies on chemotherapy for unresectable or metastatic gastric cancer, including targeted therapies and immunotherapies. |
| format | Article |
| id | doaj-art-281366f8ac7b4e9cbf54eb828fb6e99b |
| institution | Kabale University |
| issn | 1598-9992 2233-6869 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Jin Publishing & Printing Co. |
| record_format | Article |
| series | The Korean Journal of Gastroenterology |
| spelling | doaj-art-281366f8ac7b4e9cbf54eb828fb6e99b2025-02-07T05:57:09ZengJin Publishing & Printing Co.The Korean Journal of Gastroenterology1598-99922233-68692025-01-0185111010.4166/kjg.2024.139Chemotherapy for Metastatic Gastric CancerSung Eun Kim0Moo In Park1https://orcid.org/0000-0003-2071-6957Myung Hun Lee2Department of Internal Medicine, Kosin University College of Medicine, Busan, KoreaDepartment of Internal Medicine, Kosin University College of Medicine, Busan, KoreaDepartment of Internal Medicine, Kosin University College of Medicine, Busan, KoreaGastric cancer is the fourth most common malignancy in Korea and remains the fifth and seventh leading cause of cancer death in males and females, respectively. Although the survival rates for gastric cancer have improved, unresectable or metastatic gastric cancer still has an abysmal prognosis, and the five-year survival rate for patients with stage IV gastric cancer is approximately 6.6% in Korea. The treatment of patients with unresectable or metastatic gastric cancer is based on chemotherapy. A combination of fluoropyrimidine and platinum is the most widely used first-line treatment for gastric cancer worldwide. In recent decades, a better understanding of cancer biology has led to targeted therapies becoming the treatment paradigm for many cancers, including gastric cancer. In addition, immunotherapies have also been reported to improve survival in several cancers, particularly in patients with unresectable or metastatic gastric cancer who have failed multiple lines of chemotherapy. This review evaluates landmark studies on chemotherapy for unresectable or metastatic gastric cancer, including targeted therapies and immunotherapies.https://www.kjg.or.kr/journal/view.html?uid=6074&vmd=Fullstomach neoplasmsadenocarcinomaneoplasm metastasisdrug therapy |
| spellingShingle | Sung Eun Kim Moo In Park Myung Hun Lee Chemotherapy for Metastatic Gastric Cancer The Korean Journal of Gastroenterology stomach neoplasms adenocarcinoma neoplasm metastasis drug therapy |
| title | Chemotherapy for Metastatic Gastric Cancer |
| title_full | Chemotherapy for Metastatic Gastric Cancer |
| title_fullStr | Chemotherapy for Metastatic Gastric Cancer |
| title_full_unstemmed | Chemotherapy for Metastatic Gastric Cancer |
| title_short | Chemotherapy for Metastatic Gastric Cancer |
| title_sort | chemotherapy for metastatic gastric cancer |
| topic | stomach neoplasms adenocarcinoma neoplasm metastasis drug therapy |
| url | https://www.kjg.or.kr/journal/view.html?uid=6074&vmd=Full |
| work_keys_str_mv | AT sungeunkim chemotherapyformetastaticgastriccancer AT mooinpark chemotherapyformetastaticgastriccancer AT myunghunlee chemotherapyformetastaticgastriccancer |