Rheumatoid Meningoencephalitis: A Feared Condition in the Era of TNF Blockers
Central nervous system (CNS) involvement in rheumatoid arthritis (RA) is uncommon, and most of the times, it is secondary to vasculitic processes or extra-articular rheumatoid nodules. Meningeal involvement is extremely rare. In the literature, there are a few case reports, series, and retrospective...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2018/4610260 |
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| author | Fernando Figueroa Rodriguez Kwon Minkyung Sruthi Jinna Sohail Farshad Francisco Davila |
| author_facet | Fernando Figueroa Rodriguez Kwon Minkyung Sruthi Jinna Sohail Farshad Francisco Davila |
| author_sort | Fernando Figueroa Rodriguez |
| collection | DOAJ |
| description | Central nervous system (CNS) involvement in rheumatoid arthritis (RA) is uncommon, and most of the times, it is secondary to vasculitic processes or extra-articular rheumatoid nodules. Meningeal involvement is extremely rare. In the literature, there are a few case reports, series, and retrospective studies which have demonstrated the association of rheumatoid (aseptic) meningoencephalitis after starting tumor necrosis factor (TNF) inhibitors. We present a case of rheumatoid meningoencephalitis (RME) in a 52-year-old male with a history of RA on adalimumab who presented with headaches associated with motor and sensory deficits, all of which resolved after this diagnosis was achieved and received appropriate therapy with high-dose glucocorticoids. We also present an update with high yield points summarizing clinical features, diagnostic workup, and management of RME. Finally, we post a literature review of relevant CNS rheumatoid disease in patients with and without exposure to TNF inhibitors. |
| format | Article |
| id | doaj-art-280f8fc0fdc0457091358f6dee3ef9ae |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-280f8fc0fdc0457091358f6dee3ef9ae2025-02-03T01:24:16ZengWileyCase Reports in Rheumatology2090-68892090-68972018-01-01201810.1155/2018/46102604610260Rheumatoid Meningoencephalitis: A Feared Condition in the Era of TNF BlockersFernando Figueroa Rodriguez0Kwon Minkyung1Sruthi Jinna2Sohail Farshad3Francisco Davila4Beaumont Health, Department of Medicine, Royal Oak, MI, USABeaumont Health, Department of Medicine, Royal Oak, MI, USABeaumont Health, Department of Medicine, Royal Oak, MI, USABeaumont Health, Department of Medicine, Royal Oak, MI, USABeaumont Health, Department of Medicine, Royal Oak, MI, USACentral nervous system (CNS) involvement in rheumatoid arthritis (RA) is uncommon, and most of the times, it is secondary to vasculitic processes or extra-articular rheumatoid nodules. Meningeal involvement is extremely rare. In the literature, there are a few case reports, series, and retrospective studies which have demonstrated the association of rheumatoid (aseptic) meningoencephalitis after starting tumor necrosis factor (TNF) inhibitors. We present a case of rheumatoid meningoencephalitis (RME) in a 52-year-old male with a history of RA on adalimumab who presented with headaches associated with motor and sensory deficits, all of which resolved after this diagnosis was achieved and received appropriate therapy with high-dose glucocorticoids. We also present an update with high yield points summarizing clinical features, diagnostic workup, and management of RME. Finally, we post a literature review of relevant CNS rheumatoid disease in patients with and without exposure to TNF inhibitors.http://dx.doi.org/10.1155/2018/4610260 |
| spellingShingle | Fernando Figueroa Rodriguez Kwon Minkyung Sruthi Jinna Sohail Farshad Francisco Davila Rheumatoid Meningoencephalitis: A Feared Condition in the Era of TNF Blockers Case Reports in Rheumatology |
| title | Rheumatoid Meningoencephalitis: A Feared Condition in the Era of TNF Blockers |
| title_full | Rheumatoid Meningoencephalitis: A Feared Condition in the Era of TNF Blockers |
| title_fullStr | Rheumatoid Meningoencephalitis: A Feared Condition in the Era of TNF Blockers |
| title_full_unstemmed | Rheumatoid Meningoencephalitis: A Feared Condition in the Era of TNF Blockers |
| title_short | Rheumatoid Meningoencephalitis: A Feared Condition in the Era of TNF Blockers |
| title_sort | rheumatoid meningoencephalitis a feared condition in the era of tnf blockers |
| url | http://dx.doi.org/10.1155/2018/4610260 |
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