N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1

N1-methylnicotinamide promotes age-related cochlear damage via the overexpression of SIRT1

Age-related hearing loss (ARHL) is a complex condition with genetic, aging, and environmental influences. Sirtuins, particularly SIRT1, are NAD-dependent protein deacetylases critical to aging and stress responses. SIRT1 is modulated by nicotinamide N-methyltransferase (NNMT) and its product, N1-met...

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Main Authors: Toru Miwa, Akihito Tarui, Teppei Kouga, Yasunori Asai, Hideaki Ogita, Taro Fujikawa, Nobuhiro Hakuba
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
age related hearing loss
Sirtuin 1
N1-methylnicotinamide
spiral ligament
metabolome
auditory brainstem responses
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1542164/full
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