Associations of Muscle‐Related Metrics With Respiratory Disease in Chinese Adults: A Prospective Cohort Study
ABSTRACT Background There is limited evidence about the association of muscle mass, strength and quality with respiratory disease, especially in Chinese populations. We aimed to comprehensively examine such associations and identify better metrics with more clinical and public health relevance. Meth...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | Journal of Cachexia, Sarcopenia and Muscle |
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| Online Access: | https://doi.org/10.1002/jcsm.13650 |
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| author | Yongbing Lan Yalei Ke Dianjianyi Sun Pei Pei Ling Yang Yiping Chen Huaidong Du Silu Lv Maxim Barnard Junshi Chen Zhengming Chen Jun Lv Liming Li Canqing Yu China Kadoorie Biobank Collaborative Group |
| author_facet | Yongbing Lan Yalei Ke Dianjianyi Sun Pei Pei Ling Yang Yiping Chen Huaidong Du Silu Lv Maxim Barnard Junshi Chen Zhengming Chen Jun Lv Liming Li Canqing Yu China Kadoorie Biobank Collaborative Group |
| author_sort | Yongbing Lan |
| collection | DOAJ |
| description | ABSTRACT Background There is limited evidence about the association of muscle mass, strength and quality with respiratory disease, especially in Chinese populations. We aimed to comprehensively examine such associations and identify better metrics with more clinical and public health relevance. Methods We conducted a prospective cohort study based on data from the second resurvey of the China Kadoorie Biobank (CKB) study in participants with no prevalent respiratory disease or cancer. Arm muscle quality was calculated as the ratio of grip strength to arm muscle mass. Low muscle mass, grip strength and arm muscle quality were defined as the sex‐specific lowest quintiles of corresponding variables. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for respiratory disease. Results In total, 17 510 participants aged 38–88 (65.4% women; mean age 57.8 ± 9.6) were enrolled in 2013–2014 and followed up until 31 December 2018. During a median follow‐up of 4.82 years, 1346 participants developed respiratory disease. After adjustment for sociodemographic characteristics, lifestyle factors and medical histories, the elevated HR of respiratory disease was 1.31 (1.14–1.51) for low grip strength and 1.25 (1.09–1.44) for low arm muscle quality. Grip strength and arm muscle quality exhibited a linearly inverse association between respiratory disease (p = 0.137 and 0.102), with each standard deviation (SD) decrease in grip strength and arm muscle quality associated with a 22% (95% CI: 11%–34%) and 14% (95% CI: 7%–22%) increased risk of respiratory disease. No association was found for low total muscle mass index and low appendicular muscle mass index. Conclusion Low grip strength and arm muscle quality are associated with increased risks of respiratory disease, and they are better muscle‐related metrics for identifying adults at high risk of respiratory disease. Chinese adults may need to maintain normal muscle mass, strength and quality to achieve better respiratory health, but this needs to be validated in appropriately designed clinical trials. |
| format | Article |
| id | doaj-art-280e5a68201644bca5eb9728db16efd7 |
| institution | OA Journals |
| issn | 2190-5991 2190-6009 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
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| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj-art-280e5a68201644bca5eb9728db16efd72025-08-20T02:06:27ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092025-02-01161n/an/a10.1002/jcsm.13650Associations of Muscle‐Related Metrics With Respiratory Disease in Chinese Adults: A Prospective Cohort StudyYongbing Lan0Yalei Ke1Dianjianyi Sun2Pei Pei3Ling Yang4Yiping Chen5Huaidong Du6Silu Lv7Maxim Barnard8Junshi Chen9Zhengming Chen10Jun Lv11Liming Li12Canqing Yu13China Kadoorie Biobank Collaborative GroupDepartment of Epidemiology and Biostatistics, School of Public Health Peking University Beijing ChinaDepartment of Epidemiology and Biostatistics, School of Public Health Peking University Beijing ChinaDepartment of Epidemiology and Biostatistics, School of Public Health Peking University Beijing ChinaPeking University Center for Public Health and Epidemic Preparedness and Response Beijing ChinaClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford UKClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford UKClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford UKLicang Center for Disease Control and Prevention Qingdao ChinaClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford UKChina National Center for Food Safety Risk Assessment Beijing ChinaClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford UKDepartment of Epidemiology and Biostatistics, School of Public Health Peking University Beijing ChinaDepartment of Epidemiology and Biostatistics, School of Public Health Peking University Beijing ChinaDepartment of Epidemiology and Biostatistics, School of Public Health Peking University Beijing ChinaABSTRACT Background There is limited evidence about the association of muscle mass, strength and quality with respiratory disease, especially in Chinese populations. We aimed to comprehensively examine such associations and identify better metrics with more clinical and public health relevance. Methods We conducted a prospective cohort study based on data from the second resurvey of the China Kadoorie Biobank (CKB) study in participants with no prevalent respiratory disease or cancer. Arm muscle quality was calculated as the ratio of grip strength to arm muscle mass. Low muscle mass, grip strength and arm muscle quality were defined as the sex‐specific lowest quintiles of corresponding variables. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for respiratory disease. Results In total, 17 510 participants aged 38–88 (65.4% women; mean age 57.8 ± 9.6) were enrolled in 2013–2014 and followed up until 31 December 2018. During a median follow‐up of 4.82 years, 1346 participants developed respiratory disease. After adjustment for sociodemographic characteristics, lifestyle factors and medical histories, the elevated HR of respiratory disease was 1.31 (1.14–1.51) for low grip strength and 1.25 (1.09–1.44) for low arm muscle quality. Grip strength and arm muscle quality exhibited a linearly inverse association between respiratory disease (p = 0.137 and 0.102), with each standard deviation (SD) decrease in grip strength and arm muscle quality associated with a 22% (95% CI: 11%–34%) and 14% (95% CI: 7%–22%) increased risk of respiratory disease. No association was found for low total muscle mass index and low appendicular muscle mass index. Conclusion Low grip strength and arm muscle quality are associated with increased risks of respiratory disease, and they are better muscle‐related metrics for identifying adults at high risk of respiratory disease. Chinese adults may need to maintain normal muscle mass, strength and quality to achieve better respiratory health, but this needs to be validated in appropriately designed clinical trials.https://doi.org/10.1002/jcsm.13650grip strengthmuscle massmuscle qualityprospectiverespiratory disease |
| spellingShingle | Yongbing Lan Yalei Ke Dianjianyi Sun Pei Pei Ling Yang Yiping Chen Huaidong Du Silu Lv Maxim Barnard Junshi Chen Zhengming Chen Jun Lv Liming Li Canqing Yu China Kadoorie Biobank Collaborative Group Associations of Muscle‐Related Metrics With Respiratory Disease in Chinese Adults: A Prospective Cohort Study Journal of Cachexia, Sarcopenia and Muscle grip strength muscle mass muscle quality prospective respiratory disease |
| title | Associations of Muscle‐Related Metrics With Respiratory Disease in Chinese Adults: A Prospective Cohort Study |
| title_full | Associations of Muscle‐Related Metrics With Respiratory Disease in Chinese Adults: A Prospective Cohort Study |
| title_fullStr | Associations of Muscle‐Related Metrics With Respiratory Disease in Chinese Adults: A Prospective Cohort Study |
| title_full_unstemmed | Associations of Muscle‐Related Metrics With Respiratory Disease in Chinese Adults: A Prospective Cohort Study |
| title_short | Associations of Muscle‐Related Metrics With Respiratory Disease in Chinese Adults: A Prospective Cohort Study |
| title_sort | associations of muscle related metrics with respiratory disease in chinese adults a prospective cohort study |
| topic | grip strength muscle mass muscle quality prospective respiratory disease |
| url | https://doi.org/10.1002/jcsm.13650 |
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