The relationship between biochemical parameters and antibody avidity in diabetes mellitus type 2 patients
We evaluated some biochemical and immune parameters, such as IgA, IgM, IgG, CIC, phagocytic index, T-lymphocytes, as well as avidity of antibodies in type 2 diabetic patients.Avidity, high- and low-avid antibody ratio was determined by test-systems for express-diagnostics of clinical and preclinical...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2009-06-01
|
| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/1826 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849403521285226496 |
|---|---|
| author | A. M. Efendiyev G. I. Azizova G. R. Huseynova |
| author_facet | A. M. Efendiyev G. I. Azizova G. R. Huseynova |
| author_sort | A. M. Efendiyev |
| collection | DOAJ |
| description | We evaluated some biochemical and immune parameters, such as IgA, IgM, IgG, CIC, phagocytic index, T-lymphocytes, as well as avidity of antibodies in type 2 diabetic patients.Avidity, high- and low-avid antibody ratio was determined by test-systems for express-diagnostics of clinical and preclinical forms of immunologic deficiency. All patients (n = 47), depending on the level of glycemia and disease duration were divided into 3 groups: in the stage of compensation, subcompensation and decompensation. Control group included 17 healthy subjects.Value of high-avid antibodies in diabetes mellitus patients decreased in 75, 57 and 26% respectively, whereas in healthy subjects it is 89%. Conversely, increased amount of low-avid antibodies was observed, respectively 25, 43, and 74% (11% in control).These parameters prove antibody-folding disorders in diabetes mellitus and show that, change of metabolic parameters affects antibody avidity: G class high-avid antibody level decreases and shows weak protective function. This indicates functional disorders in B-system immunity. |
| format | Article |
| id | doaj-art-280c7db28ef240a5b90570f63b3ca271 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2009-06-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-280c7db28ef240a5b90570f63b3ca2712025-08-20T03:37:16ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842009-06-0183747810.20538/1682-0363-2009-3-74-781321The relationship between biochemical parameters and antibody avidity in diabetes mellitus type 2 patientsA. M. Efendiyev0G. I. Azizova1G. R. Huseynova2Азербайджанский медицинский университетАзербайджанский медицинский университетАзербайджанский медицинский университетWe evaluated some biochemical and immune parameters, such as IgA, IgM, IgG, CIC, phagocytic index, T-lymphocytes, as well as avidity of antibodies in type 2 diabetic patients.Avidity, high- and low-avid antibody ratio was determined by test-systems for express-diagnostics of clinical and preclinical forms of immunologic deficiency. All patients (n = 47), depending on the level of glycemia and disease duration were divided into 3 groups: in the stage of compensation, subcompensation and decompensation. Control group included 17 healthy subjects.Value of high-avid antibodies in diabetes mellitus patients decreased in 75, 57 and 26% respectively, whereas in healthy subjects it is 89%. Conversely, increased amount of low-avid antibodies was observed, respectively 25, 43, and 74% (11% in control).These parameters prove antibody-folding disorders in diabetes mellitus and show that, change of metabolic parameters affects antibody avidity: G class high-avid antibody level decreases and shows weak protective function. This indicates functional disorders in B-system immunity.https://bulletin.ssmu.ru/jour/article/view/1826type 2 diabetes mellitusimmunoglobulinesantibody avidity |
| spellingShingle | A. M. Efendiyev G. I. Azizova G. R. Huseynova The relationship between biochemical parameters and antibody avidity in diabetes mellitus type 2 patients Бюллетень сибирской медицины type 2 diabetes mellitus immunoglobulines antibody avidity |
| title | The relationship between biochemical parameters and antibody avidity in diabetes mellitus type 2 patients |
| title_full | The relationship between biochemical parameters and antibody avidity in diabetes mellitus type 2 patients |
| title_fullStr | The relationship between biochemical parameters and antibody avidity in diabetes mellitus type 2 patients |
| title_full_unstemmed | The relationship between biochemical parameters and antibody avidity in diabetes mellitus type 2 patients |
| title_short | The relationship between biochemical parameters and antibody avidity in diabetes mellitus type 2 patients |
| title_sort | relationship between biochemical parameters and antibody avidity in diabetes mellitus type 2 patients |
| topic | type 2 diabetes mellitus immunoglobulines antibody avidity |
| url | https://bulletin.ssmu.ru/jour/article/view/1826 |
| work_keys_str_mv | AT amefendiyev therelationshipbetweenbiochemicalparametersandantibodyavidityindiabetesmellitustype2patients AT giazizova therelationshipbetweenbiochemicalparametersandantibodyavidityindiabetesmellitustype2patients AT grhuseynova therelationshipbetweenbiochemicalparametersandantibodyavidityindiabetesmellitustype2patients AT amefendiyev relationshipbetweenbiochemicalparametersandantibodyavidityindiabetesmellitustype2patients AT giazizova relationshipbetweenbiochemicalparametersandantibodyavidityindiabetesmellitustype2patients AT grhuseynova relationshipbetweenbiochemicalparametersandantibodyavidityindiabetesmellitustype2patients |