The role of the GABAergic system on insomnia
Sleep is an essential activity for the survival of mammals. Good sleep quality helps promote the performance of daily functions. In contrast, insufficient sleep reduces the efficiency of daily activities, causes various chronic diseases like Alzheimer's disease, and increases the risk of having...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Tzu Chi Medical Journal |
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| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2024;volume=36;issue=2;spage=103;epage=109;aulast=Varinthra |
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| author | Peeraporn Varinthra Shameemun Naseer Mohamed Nizarul Anwar Shu-Ching Shih Ingrid Y Liu |
| author_facet | Peeraporn Varinthra Shameemun Naseer Mohamed Nizarul Anwar Shu-Ching Shih Ingrid Y Liu |
| author_sort | Peeraporn Varinthra |
| collection | DOAJ |
| description | Sleep is an essential activity for the survival of mammals. Good sleep quality helps promote the performance of daily functions. In contrast, insufficient sleep reduces the efficiency of daily activities, causes various chronic diseases like Alzheimer's disease, and increases the risk of having accidents. The GABAergic system is the primary inhibitory neurotransmitter system in the central nervous system. It transits the gamma-aminobutyric acid (GABA) neurotransmitter via GABAA and GABAB receptors to counterbalance excitatory neurotransmitters, such as glutamate, noradrenaline, serotonin, acetylcholine, orexin, and dopamine, which release and increase arousal activities during sleep. Several studies emphasized that dysfunction of the GABAergic system is related to insomnia, the most prevalent sleep-related disorder. The GABAergic system comprises the GABA neurotransmitter, GABA receptors, GABA synthesis, and degradation. Many studies have demonstrated that GABA levels correlate with sleep quality, suggesting that modulating the GABAergic system may be a promising therapeutic approach for insomnia. In this article, we highlight the significance of sleep, the classification and pathology of insomnia, and the impact of the GABAergic system changes on sleep. In addition, we also review the medications that target the GABAergic systems for insomnia, including benzodiazepines (BZDs), non-BZDs, barbiturates, GABA supplements, and Chinese herbal medicines. |
| format | Article |
| id | doaj-art-280ae241163f47f0a5fc2f94b3d1098b |
| institution | DOAJ |
| issn | 1016-3190 2223-8956 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu Chi Medical Journal |
| spelling | doaj-art-280ae241163f47f0a5fc2f94b3d1098b2025-08-20T03:18:01ZengWolters Kluwer Medknow PublicationsTzu Chi Medical Journal1016-31902223-89562024-01-0136210310910.4103/tcmj.tcmj_243_23The role of the GABAergic system on insomniaPeeraporn VarinthraShameemun Naseer Mohamed Nizarul AnwarShu-Ching ShihIngrid Y LiuSleep is an essential activity for the survival of mammals. Good sleep quality helps promote the performance of daily functions. In contrast, insufficient sleep reduces the efficiency of daily activities, causes various chronic diseases like Alzheimer's disease, and increases the risk of having accidents. The GABAergic system is the primary inhibitory neurotransmitter system in the central nervous system. It transits the gamma-aminobutyric acid (GABA) neurotransmitter via GABAA and GABAB receptors to counterbalance excitatory neurotransmitters, such as glutamate, noradrenaline, serotonin, acetylcholine, orexin, and dopamine, which release and increase arousal activities during sleep. Several studies emphasized that dysfunction of the GABAergic system is related to insomnia, the most prevalent sleep-related disorder. The GABAergic system comprises the GABA neurotransmitter, GABA receptors, GABA synthesis, and degradation. Many studies have demonstrated that GABA levels correlate with sleep quality, suggesting that modulating the GABAergic system may be a promising therapeutic approach for insomnia. In this article, we highlight the significance of sleep, the classification and pathology of insomnia, and the impact of the GABAergic system changes on sleep. In addition, we also review the medications that target the GABAergic systems for insomnia, including benzodiazepines (BZDs), non-BZDs, barbiturates, GABA supplements, and Chinese herbal medicines.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2024;volume=36;issue=2;spage=103;epage=109;aulast=Varinthrabenzodiazepineschinese herbal medicinegamma-aminobutyric acidinsomniasleep |
| spellingShingle | Peeraporn Varinthra Shameemun Naseer Mohamed Nizarul Anwar Shu-Ching Shih Ingrid Y Liu The role of the GABAergic system on insomnia Tzu Chi Medical Journal benzodiazepines chinese herbal medicine gamma-aminobutyric acid insomnia sleep |
| title | The role of the GABAergic system on insomnia |
| title_full | The role of the GABAergic system on insomnia |
| title_fullStr | The role of the GABAergic system on insomnia |
| title_full_unstemmed | The role of the GABAergic system on insomnia |
| title_short | The role of the GABAergic system on insomnia |
| title_sort | role of the gabaergic system on insomnia |
| topic | benzodiazepines chinese herbal medicine gamma-aminobutyric acid insomnia sleep |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2024;volume=36;issue=2;spage=103;epage=109;aulast=Varinthra |
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