Primary Sarcoma of the Specialised Prostatic Stroma: A Case Report and Review of the Literature
Primary sarcoma tumours of the prostate are rare and are classified, according to their histology, as stromal tumours of uncertain malignant potential (STUMP) and stromal prostatic sarcoma (PS; low and high grade). We describe a case of a 71-year-old man that developed progressive urinary obstructio...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2011/252805 |
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| author | Rosanna Zamparese Francesco Corini Antonio Braccischi Antonella D'Angelo Lucilla Diamanti Marina Del Vecchio Willy Giannubilo Vladimiro Mambelli |
| author_facet | Rosanna Zamparese Francesco Corini Antonio Braccischi Antonella D'Angelo Lucilla Diamanti Marina Del Vecchio Willy Giannubilo Vladimiro Mambelli |
| author_sort | Rosanna Zamparese |
| collection | DOAJ |
| description | Primary sarcoma tumours of the prostate are rare and are classified, according to their histology, as stromal tumours of uncertain malignant potential (STUMP) and stromal prostatic sarcoma (PS; low and high grade). We describe a case of a 71-year-old man that developed progressive urinary obstruction symptoms and was subjected to a transurethral prostatic resection (TURP). Histologically, there is a diffuse proliferation of epithelioid and spindle cells that showed rare atypical mitotic figures. Immunohistochemically, the neoplastic cells express diffusely CD34 and focally progesterone whereas no immunoreactivity was seen for cytocheratin, desmin, S-100, Bcl-2, chromogranin, CD117, and actin smooth muscle. A final diagnosis of low-grade prostatic stromal sarcoma (LG-PS) was made. This is a really rare neoplasm; in the literature, in fact, to our knowledge, only 6 cases are described and all of these were alive and free of disease at followup. Our patient too is free of disease at 15 months from the diagnosis. |
| format | Article |
| id | doaj-art-280460fd2a70439989141dd6cec6fd57 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-280460fd2a70439989141dd6cec6fd572025-02-03T01:09:07ZengWileyCase Reports in Pathology2090-67812090-679X2011-01-01201110.1155/2011/252805252805Primary Sarcoma of the Specialised Prostatic Stroma: A Case Report and Review of the LiteratureRosanna Zamparese0Francesco Corini1Antonio Braccischi2Antonella D'Angelo3Lucilla Diamanti4Marina Del Vecchio5Willy Giannubilo6Vladimiro Mambelli7Departments of Pathology, General Hospital C.G. Mazzoni, 63100 Ascoli Piceno, ItalyDepartments of Pathology, General Hospital C.G. Mazzoni, 63100 Ascoli Piceno, ItalyDepartments of Pathology, General Hospital C.G. Mazzoni, 63100 Ascoli Piceno, ItalyDepartments of Pathology, General Hospital C.G. Mazzoni, 63100 Ascoli Piceno, ItalyDepartments of Pathology, General Hospital C.G. Mazzoni, 63100 Ascoli Piceno, ItalyDepartments of Pathology, General Hospital C.G. Mazzoni, 63100 Ascoli Piceno, ItalyDepartment of Urology, Central Hospital, 60035 Jesi, ItalyDepartments of Pathology, General Hospital C.G. Mazzoni, 63100 Ascoli Piceno, ItalyPrimary sarcoma tumours of the prostate are rare and are classified, according to their histology, as stromal tumours of uncertain malignant potential (STUMP) and stromal prostatic sarcoma (PS; low and high grade). We describe a case of a 71-year-old man that developed progressive urinary obstruction symptoms and was subjected to a transurethral prostatic resection (TURP). Histologically, there is a diffuse proliferation of epithelioid and spindle cells that showed rare atypical mitotic figures. Immunohistochemically, the neoplastic cells express diffusely CD34 and focally progesterone whereas no immunoreactivity was seen for cytocheratin, desmin, S-100, Bcl-2, chromogranin, CD117, and actin smooth muscle. A final diagnosis of low-grade prostatic stromal sarcoma (LG-PS) was made. This is a really rare neoplasm; in the literature, in fact, to our knowledge, only 6 cases are described and all of these were alive and free of disease at followup. Our patient too is free of disease at 15 months from the diagnosis.http://dx.doi.org/10.1155/2011/252805 |
| spellingShingle | Rosanna Zamparese Francesco Corini Antonio Braccischi Antonella D'Angelo Lucilla Diamanti Marina Del Vecchio Willy Giannubilo Vladimiro Mambelli Primary Sarcoma of the Specialised Prostatic Stroma: A Case Report and Review of the Literature Case Reports in Pathology |
| title | Primary Sarcoma of the Specialised Prostatic Stroma: A Case Report and Review of the Literature |
| title_full | Primary Sarcoma of the Specialised Prostatic Stroma: A Case Report and Review of the Literature |
| title_fullStr | Primary Sarcoma of the Specialised Prostatic Stroma: A Case Report and Review of the Literature |
| title_full_unstemmed | Primary Sarcoma of the Specialised Prostatic Stroma: A Case Report and Review of the Literature |
| title_short | Primary Sarcoma of the Specialised Prostatic Stroma: A Case Report and Review of the Literature |
| title_sort | primary sarcoma of the specialised prostatic stroma a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2011/252805 |
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