Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic Studies
Bioactive 1,1′-(4,4′-di-ferrocenyl)di-phenyl thiourea and various metal complexes of this ligand have been successfully synthesized and characterized by using physicoanalytical techniques such as FT-IR and multinuclear (1H and 13C) NMR spectroscopy along with melting point and elemental analyses. Th...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2015/386587 |
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| author | Shafqat Ali Ghulam Yasin Zareen Zuhra Zhanpeng Wu Ian S. Butler Amin Badshah Imtiaz ud Din |
| author_facet | Shafqat Ali Ghulam Yasin Zareen Zuhra Zhanpeng Wu Ian S. Butler Amin Badshah Imtiaz ud Din |
| author_sort | Shafqat Ali |
| collection | DOAJ |
| description | Bioactive 1,1′-(4,4′-di-ferrocenyl)di-phenyl thiourea and various metal complexes of this ligand have been successfully synthesized and characterized by using physicoanalytical techniques such as FT-IR and multinuclear (1H and 13C) NMR spectroscopy along with melting point and elemental analyses. The interaction of the synthesized compounds with DNA has been investigated by using cyclic voltammetric and viscometric measurements. The intercalation of the complexes into the double helix structure of DNA is presumably occurring. Viscosity measurements of the complexes have shown that there is a change in length and this is regarded as the least ambiguous and the most critical test of the binding model in solution. The relative potential of the complexes as anti-bacterial, antifungal, and inhibition agents against the enzyme, alkaline phosphatase EC 3.1.3.1, has also been assessed and the complexes were found to be active inhibitors. |
| format | Article |
| id | doaj-art-27fe361cd0b94f0a83fad54253a3d72c |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-27fe361cd0b94f0a83fad54253a3d72c2025-02-03T01:13:04ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2015-01-01201510.1155/2015/386587386587Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic StudiesShafqat Ali0Ghulam Yasin1Zareen Zuhra2Zhanpeng Wu3Ian S. Butler4Amin Badshah5Imtiaz ud Din6Key Laboratory of Carbon Fiber and Functional Polymers, Beijing University of Chemical Technology Ministry of Education, Beijing 100029, ChinaKey Laboratory of Carbon Fiber and Functional Polymers, Beijing University of Chemical Technology Ministry of Education, Beijing 100029, ChinaKey Laboratory of Carbon Fiber and Functional Polymers, Beijing University of Chemical Technology Ministry of Education, Beijing 100029, ChinaKey Laboratory of Carbon Fiber and Functional Polymers, Beijing University of Chemical Technology Ministry of Education, Beijing 100029, ChinaDepartment of Chemistry, McGill University, Montreal, QC, H3A 2K6, CanadaDepartment of Chemistry, Quaid-i-Azam University, Islamabad 45320, PakistanDepartment of Chemistry, Quaid-i-Azam University, Islamabad 45320, PakistanBioactive 1,1′-(4,4′-di-ferrocenyl)di-phenyl thiourea and various metal complexes of this ligand have been successfully synthesized and characterized by using physicoanalytical techniques such as FT-IR and multinuclear (1H and 13C) NMR spectroscopy along with melting point and elemental analyses. The interaction of the synthesized compounds with DNA has been investigated by using cyclic voltammetric and viscometric measurements. The intercalation of the complexes into the double helix structure of DNA is presumably occurring. Viscosity measurements of the complexes have shown that there is a change in length and this is regarded as the least ambiguous and the most critical test of the binding model in solution. The relative potential of the complexes as anti-bacterial, antifungal, and inhibition agents against the enzyme, alkaline phosphatase EC 3.1.3.1, has also been assessed and the complexes were found to be active inhibitors.http://dx.doi.org/10.1155/2015/386587 |
| spellingShingle | Shafqat Ali Ghulam Yasin Zareen Zuhra Zhanpeng Wu Ian S. Butler Amin Badshah Imtiaz ud Din Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic Studies Bioinorganic Chemistry and Applications |
| title | Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic Studies |
| title_full | Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic Studies |
| title_fullStr | Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic Studies |
| title_full_unstemmed | Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic Studies |
| title_short | Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic Studies |
| title_sort | ferrocene based bioactive bimetallic thiourea complexes synthesis and spectroscopic studies |
| url | http://dx.doi.org/10.1155/2015/386587 |
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