Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort
Abstract Introduction Using the ATN framework, we evaluated the potential of plasma biomarkers to identify abnormal brain amyloid-beta (Aβ) positron emission tomography (PET), tau-PET and neurodegeneration in a socioeconomically disadvantaged population-based cohort. Methods Community-dwelling demen...
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BMC
2025-07-01
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| Series: | Alzheimer’s Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13195-025-01803-w |
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| author | Menayit Tamrat Dresse Pamela C. L. Ferreira Akshay Prasadan Jihui L. Diaz Xuemei Zeng Bruna Bellaver Guilherme Povala Victor L. Villemagne M. Ilyas Kamboh Ann D. Cohen Tharick A. Pascoal Mary Ganguli Beth E. Snitz C. Elizabeth Shaaban Thomas K. Karikari |
| author_facet | Menayit Tamrat Dresse Pamela C. L. Ferreira Akshay Prasadan Jihui L. Diaz Xuemei Zeng Bruna Bellaver Guilherme Povala Victor L. Villemagne M. Ilyas Kamboh Ann D. Cohen Tharick A. Pascoal Mary Ganguli Beth E. Snitz C. Elizabeth Shaaban Thomas K. Karikari |
| author_sort | Menayit Tamrat Dresse |
| collection | DOAJ |
| description | Abstract Introduction Using the ATN framework, we evaluated the potential of plasma biomarkers to identify abnormal brain amyloid-beta (Aβ) positron emission tomography (PET), tau-PET and neurodegeneration in a socioeconomically disadvantaged population-based cohort. Methods Community-dwelling dementia-free (n = 113, including 102 (91%) cognitively normal) participants underwent ATN neuroimaging and plasma biomarker assessments. Results Plasma Aβ42/Aβ40, p-tau181, and p-tau217 showed significant associations with Aβ-PET status, (adjusted odds ratio [AOR] of 1.74*10–24, 1.47, and 3.43*103, respectively (p-values < 0.05), with p-tau217 demonstrating the highest classification accuracy for Aβ-PET status (AUC = 0.94). Plasma p-tau181 and p-tau217 showed significant associations with tau-PET status (AOR: 1.50 and 22.24, respectively (p-values < 0.05), with comparable classification accuracies for tau-PET status (AUC = 0.74 and 0.70, respectively). Only plasma NfL showed significant association with neurodegeneration based on cortical thickness (AOR = 1.09, p-value < 0.05). Conclusion Our findings highlight the potential of plasma p-tau217 as a biomarker for brain Aβ and tau pathophysiology, p-tau181 for tau abnormalities, and NfL for neurodegeneration in the community. |
| format | Article |
| id | doaj-art-27f5f5cd40d145f285a7a552f563b4e2 |
| institution | Kabale University |
| issn | 1758-9193 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj-art-27f5f5cd40d145f285a7a552f563b4e22025-08-20T03:46:07ZengBMCAlzheimer’s Research & Therapy1758-91932025-07-0117111410.1186/s13195-025-01803-wPlasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohortMenayit Tamrat Dresse0Pamela C. L. Ferreira1Akshay Prasadan2Jihui L. Diaz3Xuemei Zeng4Bruna Bellaver5Guilherme Povala6Victor L. Villemagne7M. Ilyas Kamboh8Ann D. Cohen9Tharick A. Pascoal10Mary Ganguli11Beth E. Snitz12C. Elizabeth Shaaban13Thomas K. Karikari14Department of Epidemiology, School of Public Health, University of PittsburghDepartment of Psychiatry, School of Medicine, University of PittsburghDepartment of Statistics & Data Science, Dietrich College of Humanities and Social Sciences, Carnegie Mellon UniversityDepartment of Psychiatry, School of Medicine, University of PittsburghDepartment of Psychiatry, School of Medicine, University of PittsburghDepartment of Psychiatry, School of Medicine, University of PittsburghDepartment of Psychiatry, School of Medicine, University of PittsburghDepartment of Psychiatry, School of Medicine, University of PittsburghAlzheimer’s Disease Research Center, University of PittsburghDepartment of Psychiatry, School of Medicine, University of PittsburghDepartment of Psychiatry, School of Medicine, University of PittsburghDepartment of Epidemiology, School of Public Health, University of PittsburghAlzheimer’s Disease Research Center, University of PittsburghDepartment of Epidemiology, School of Public Health, University of PittsburghDepartment of Psychiatry, School of Medicine, University of PittsburghAbstract Introduction Using the ATN framework, we evaluated the potential of plasma biomarkers to identify abnormal brain amyloid-beta (Aβ) positron emission tomography (PET), tau-PET and neurodegeneration in a socioeconomically disadvantaged population-based cohort. Methods Community-dwelling dementia-free (n = 113, including 102 (91%) cognitively normal) participants underwent ATN neuroimaging and plasma biomarker assessments. Results Plasma Aβ42/Aβ40, p-tau181, and p-tau217 showed significant associations with Aβ-PET status, (adjusted odds ratio [AOR] of 1.74*10–24, 1.47, and 3.43*103, respectively (p-values < 0.05), with p-tau217 demonstrating the highest classification accuracy for Aβ-PET status (AUC = 0.94). Plasma p-tau181 and p-tau217 showed significant associations with tau-PET status (AOR: 1.50 and 22.24, respectively (p-values < 0.05), with comparable classification accuracies for tau-PET status (AUC = 0.74 and 0.70, respectively). Only plasma NfL showed significant association with neurodegeneration based on cortical thickness (AOR = 1.09, p-value < 0.05). Conclusion Our findings highlight the potential of plasma p-tau217 as a biomarker for brain Aβ and tau pathophysiology, p-tau181 for tau abnormalities, and NfL for neurodegeneration in the community.https://doi.org/10.1186/s13195-025-01803-wAmyloid betaTau pathologyNeurodegenerationNeuroimagingATN frameworkP-tau217 |
| spellingShingle | Menayit Tamrat Dresse Pamela C. L. Ferreira Akshay Prasadan Jihui L. Diaz Xuemei Zeng Bruna Bellaver Guilherme Povala Victor L. Villemagne M. Ilyas Kamboh Ann D. Cohen Tharick A. Pascoal Mary Ganguli Beth E. Snitz C. Elizabeth Shaaban Thomas K. Karikari Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort Alzheimer’s Research & Therapy Amyloid beta Tau pathology Neurodegeneration Neuroimaging ATN framework P-tau217 |
| title | Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort |
| title_full | Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort |
| title_fullStr | Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort |
| title_full_unstemmed | Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort |
| title_short | Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort |
| title_sort | plasma biomarkers identify brain atn abnormalities in a dementia free population based cohort |
| topic | Amyloid beta Tau pathology Neurodegeneration Neuroimaging ATN framework P-tau217 |
| url | https://doi.org/10.1186/s13195-025-01803-w |
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