Nitrous Oxide Persistently Alleviates Pain Hypersensitivity in Neuropathic Rats: A Dose-Dependent Effect
BACKGROUND: Despite numerous pharmacological approaches, there are no common analgesic drugs that produce meaningful relief for the majority of patients with neuropathic pain. Although nitrous oxide (N2O) is a weak analgesic that acts via opioid-dependent mechanisms, it is also an antagonist of the...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2015/809059 |
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| author | Meric Ben Boujema Emilie Laboureyras Jan Pype Baptiste Bessière Guy Simonnet |
| author_facet | Meric Ben Boujema Emilie Laboureyras Jan Pype Baptiste Bessière Guy Simonnet |
| author_sort | Meric Ben Boujema |
| collection | DOAJ |
| description | BACKGROUND: Despite numerous pharmacological approaches, there are no common analgesic drugs that produce meaningful relief for the majority of patients with neuropathic pain. Although nitrous oxide (N2O) is a weak analgesic that acts via opioid-dependent mechanisms, it is also an antagonist of the N-methyl-D-aspartate receptor (NMDAR). The NMDAR plays a critical role in the development of pain sensitization induced by nerve injury. |
| format | Article |
| id | doaj-art-27f1cd841b174c2e836ae6c450fce4b7 |
| institution | OA Journals |
| issn | 1203-6765 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-27f1cd841b174c2e836ae6c450fce4b72025-08-20T02:04:20ZengWileyPain Research and Management1203-67652015-01-0120630931510.1155/2015/809059Nitrous Oxide Persistently Alleviates Pain Hypersensitivity in Neuropathic Rats: A Dose-Dependent EffectMeric Ben Boujema0Emilie Laboureyras1Jan Pype2Baptiste Bessière3Guy Simonnet4Team “Homéostasie-Allostasie-Pathologie-Réhabilitation”, UMR CNRS 5287, INCIA, Université de Bordeaux, Bordeaux, FranceTeam “Homéostasie-Allostasie-Pathologie-Réhabilitation”, UMR CNRS 5287, INCIA, Université de Bordeaux, Bordeaux, FranceAir Liquide Santé International, Centre de Recherche Paris-Saclay, Jouy-en-Josas, FranceAir Liquide Santé International, Centre de Recherche Paris-Saclay, Jouy-en-Josas, FranceTeam “Homéostasie-Allostasie-Pathologie-Réhabilitation”, UMR CNRS 5287, INCIA, Université de Bordeaux, Bordeaux, FranceBACKGROUND: Despite numerous pharmacological approaches, there are no common analgesic drugs that produce meaningful relief for the majority of patients with neuropathic pain. Although nitrous oxide (N2O) is a weak analgesic that acts via opioid-dependent mechanisms, it is also an antagonist of the N-methyl-D-aspartate receptor (NMDAR). The NMDAR plays a critical role in the development of pain sensitization induced by nerve injury.http://dx.doi.org/10.1155/2015/809059 |
| spellingShingle | Meric Ben Boujema Emilie Laboureyras Jan Pype Baptiste Bessière Guy Simonnet Nitrous Oxide Persistently Alleviates Pain Hypersensitivity in Neuropathic Rats: A Dose-Dependent Effect Pain Research and Management |
| title | Nitrous Oxide Persistently Alleviates Pain Hypersensitivity in Neuropathic Rats: A Dose-Dependent Effect |
| title_full | Nitrous Oxide Persistently Alleviates Pain Hypersensitivity in Neuropathic Rats: A Dose-Dependent Effect |
| title_fullStr | Nitrous Oxide Persistently Alleviates Pain Hypersensitivity in Neuropathic Rats: A Dose-Dependent Effect |
| title_full_unstemmed | Nitrous Oxide Persistently Alleviates Pain Hypersensitivity in Neuropathic Rats: A Dose-Dependent Effect |
| title_short | Nitrous Oxide Persistently Alleviates Pain Hypersensitivity in Neuropathic Rats: A Dose-Dependent Effect |
| title_sort | nitrous oxide persistently alleviates pain hypersensitivity in neuropathic rats a dose dependent effect |
| url | http://dx.doi.org/10.1155/2015/809059 |
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