Implementation of an Interdepartmental Collaborative Medication Review to Reduce Potentially Inappropriate Medication Use in Hospitalized Older Adults: Protocol for a Mixed Methods Study
BackgroundThe inappropriate use of multiple medications known as polypharmacy is a growing concern for older populations with comorbid conditions in India. Polypharmacy can lead to serious adverse health outcomes, increased health care costs, and reduced quality of life. Scre...
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JMIR Publications
2025-07-01
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| Series: | JMIR Research Protocols |
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| author | Aravinda Kumar Rajesh Kumar Konduru Saranya Rajaram Manikandan Mani Anusha Natarajan Jerin Jose Cherian Bhavani Shankara Bagepally Anil Jacob Purty Nayyar Iqbal Dineshbabu Sekar Sudharsanan Sundaramurthi Isabella Topno Manjunatha Chalawadi Hanumappa |
| author_facet | Aravinda Kumar Rajesh Kumar Konduru Saranya Rajaram Manikandan Mani Anusha Natarajan Jerin Jose Cherian Bhavani Shankara Bagepally Anil Jacob Purty Nayyar Iqbal Dineshbabu Sekar Sudharsanan Sundaramurthi Isabella Topno Manjunatha Chalawadi Hanumappa |
| author_sort | Aravinda Kumar |
| collection | DOAJ |
| description |
BackgroundThe inappropriate use of multiple medications known as polypharmacy is a growing concern for older populations with comorbid conditions in India. Polypharmacy can lead to serious adverse health outcomes, increased health care costs, and reduced quality of life. Screening tools such as the Medication Appropriateness Index (MAI) and Screening Tool for Older Persons’ Prescriptions (STOPP) or Screening Tool to Alert to Right Treatment (START) criteria can help identify potentially inappropriate medications, and interventions such as medication review clinics and prescribing audits can help improve the appropriateness. A collaborative medication review (CMR) involving a team approach is important to ensure that patients receive the best possible care.
ObjectiveThe primary objective is to assess the feasibility of implementation of interdepartmental CMR to reduce potentially inappropriate medications in hospitalized older adults. The secondary objectives are to (1) explore the facilitators and barriers in this implementation from the health care providers’ perspective, (2) determine the costs involved in the implementation from a health system perspective, and (3) analyze the efficacy of interdepartmental CMR by using MAI, postdischarge adverse events, and number of medication-related admissions.
MethodsThis study consists of 5 phases aimed at improving CMR practices in India. Phase 1 focused on conducting a scoping review of CMR practices. Phase 2 involved creating standard operating procedures to establish a CMR team, delineating roles and responsibilities, and providing training. Phase 3 will evaluate the efficacy of CMR by using standardized tools such as MAI and STOPP/START criteria. Phase 4 assesses the challenges faced in implementing CMR. Finally, phase 5 analyzes the costs related to CMR implementation. This study employs a multicentered mixed methods approach, combining qualitative methods (in-depth interviews and focus group discussions) to explore implementation challenges and quantitative analysis through a quasi-experimental study involving 280 hospitalized older adults. It aims to measure costs and the reduction of potentially inappropriate medications post discharge.
ResultsThis study received a grant from the Indian Council of Medical Research–Safe and Rational Use of Medicine Task Force in December 2023. All study preparatory approvals were obtained. Phase 1 and phase 2 were completed by December 2024. Phase 3 is scheduled to finish by June 2025. Phases 4 and 5 are planned for completion by August 2025. Final data analysis and manuscript submission are expected by December 2025.
ConclusionsThis study can provide insights into the implementation and effectiveness of CMR and help to understand the facilitators and barriers to implementing interdepartmental CMR and the cost incurred in its implementation. Interprofessional teams will collaboratively review and optimize medications for older patients with multimorbidity in India—a strategy expected to enhance care coordination, improve clinical outcomes, and reduce health care costs.
Trial RegistrationClinical Trials Registry – India CTRI/2024/06/069220; https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=OTgyNDg=&Enc=&userName= |
| format | Article |
| id | doaj-art-27ebb257596241f891e47c0f3da6f303 |
| institution | DOAJ |
| issn | 1929-0748 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | JMIR Publications |
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| series | JMIR Research Protocols |
| spelling | doaj-art-27ebb257596241f891e47c0f3da6f3032025-08-20T02:47:25ZengJMIR PublicationsJMIR Research Protocols1929-07482025-07-0114e6962610.2196/69626Implementation of an Interdepartmental Collaborative Medication Review to Reduce Potentially Inappropriate Medication Use in Hospitalized Older Adults: Protocol for a Mixed Methods StudyAravinda Kumarhttps://orcid.org/0000-0001-8945-4399Rajesh Kumar Konduruhttps://orcid.org/0009-0003-3868-6669Saranya Rajaramhttps://orcid.org/0009-0007-4026-7032Manikandan Manihttps://orcid.org/0000-0001-8425-016XAnusha Natarajanhttps://orcid.org/0000-0003-4839-1517Jerin Jose Cherianhttps://orcid.org/0000-0002-9548-7004Bhavani Shankara Bagepallyhttps://orcid.org/0000-0003-0856-767XAnil Jacob Purtyhttps://orcid.org/0000-0001-7618-4844Nayyar Iqbalhttps://orcid.org/0000-0002-7063-3677Dineshbabu Sekarhttps://orcid.org/0000-0003-3756-1621Sudharsanan Sundaramurthihttps://orcid.org/0000-0001-9383-3770Isabella Topnohttps://orcid.org/0009-0004-9124-5202Manjunatha Chalawadi Hanumappahttps://orcid.org/0009-0000-5878-5363 BackgroundThe inappropriate use of multiple medications known as polypharmacy is a growing concern for older populations with comorbid conditions in India. Polypharmacy can lead to serious adverse health outcomes, increased health care costs, and reduced quality of life. Screening tools such as the Medication Appropriateness Index (MAI) and Screening Tool for Older Persons’ Prescriptions (STOPP) or Screening Tool to Alert to Right Treatment (START) criteria can help identify potentially inappropriate medications, and interventions such as medication review clinics and prescribing audits can help improve the appropriateness. A collaborative medication review (CMR) involving a team approach is important to ensure that patients receive the best possible care. ObjectiveThe primary objective is to assess the feasibility of implementation of interdepartmental CMR to reduce potentially inappropriate medications in hospitalized older adults. The secondary objectives are to (1) explore the facilitators and barriers in this implementation from the health care providers’ perspective, (2) determine the costs involved in the implementation from a health system perspective, and (3) analyze the efficacy of interdepartmental CMR by using MAI, postdischarge adverse events, and number of medication-related admissions. MethodsThis study consists of 5 phases aimed at improving CMR practices in India. Phase 1 focused on conducting a scoping review of CMR practices. Phase 2 involved creating standard operating procedures to establish a CMR team, delineating roles and responsibilities, and providing training. Phase 3 will evaluate the efficacy of CMR by using standardized tools such as MAI and STOPP/START criteria. Phase 4 assesses the challenges faced in implementing CMR. Finally, phase 5 analyzes the costs related to CMR implementation. This study employs a multicentered mixed methods approach, combining qualitative methods (in-depth interviews and focus group discussions) to explore implementation challenges and quantitative analysis through a quasi-experimental study involving 280 hospitalized older adults. It aims to measure costs and the reduction of potentially inappropriate medications post discharge. ResultsThis study received a grant from the Indian Council of Medical Research–Safe and Rational Use of Medicine Task Force in December 2023. All study preparatory approvals were obtained. Phase 1 and phase 2 were completed by December 2024. Phase 3 is scheduled to finish by June 2025. Phases 4 and 5 are planned for completion by August 2025. Final data analysis and manuscript submission are expected by December 2025. ConclusionsThis study can provide insights into the implementation and effectiveness of CMR and help to understand the facilitators and barriers to implementing interdepartmental CMR and the cost incurred in its implementation. Interprofessional teams will collaboratively review and optimize medications for older patients with multimorbidity in India—a strategy expected to enhance care coordination, improve clinical outcomes, and reduce health care costs. Trial RegistrationClinical Trials Registry – India CTRI/2024/06/069220; https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=OTgyNDg=&Enc=&userName=https://www.researchprotocols.org/2025/1/e69626 |
| spellingShingle | Aravinda Kumar Rajesh Kumar Konduru Saranya Rajaram Manikandan Mani Anusha Natarajan Jerin Jose Cherian Bhavani Shankara Bagepally Anil Jacob Purty Nayyar Iqbal Dineshbabu Sekar Sudharsanan Sundaramurthi Isabella Topno Manjunatha Chalawadi Hanumappa Implementation of an Interdepartmental Collaborative Medication Review to Reduce Potentially Inappropriate Medication Use in Hospitalized Older Adults: Protocol for a Mixed Methods Study JMIR Research Protocols |
| title | Implementation of an Interdepartmental Collaborative Medication Review to Reduce Potentially Inappropriate Medication Use in Hospitalized Older Adults: Protocol for a Mixed Methods Study |
| title_full | Implementation of an Interdepartmental Collaborative Medication Review to Reduce Potentially Inappropriate Medication Use in Hospitalized Older Adults: Protocol for a Mixed Methods Study |
| title_fullStr | Implementation of an Interdepartmental Collaborative Medication Review to Reduce Potentially Inappropriate Medication Use in Hospitalized Older Adults: Protocol for a Mixed Methods Study |
| title_full_unstemmed | Implementation of an Interdepartmental Collaborative Medication Review to Reduce Potentially Inappropriate Medication Use in Hospitalized Older Adults: Protocol for a Mixed Methods Study |
| title_short | Implementation of an Interdepartmental Collaborative Medication Review to Reduce Potentially Inappropriate Medication Use in Hospitalized Older Adults: Protocol for a Mixed Methods Study |
| title_sort | implementation of an interdepartmental collaborative medication review to reduce potentially inappropriate medication use in hospitalized older adults protocol for a mixed methods study |
| url | https://www.researchprotocols.org/2025/1/e69626 |
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