Distinct Clinicopathological Features and Prognosis of Helicobacter pylori Negative Gastric Cancer.
<h4>Background</h4>Whether the characteristics and prognosis of gastric cancer (GC) are different in patients with and without Helicobacter pylori (HP) remains controversial. The definitions of HP status in patients with atrophic gastritis but negative tests for HP are heterogeneous. We...
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Public Library of Science (PLoS)
2017-01-01
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| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170942&type=printable |
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| author | Kun-Feng Tsai Jyh-Ming Liou Mei-Jyh Chen Chien-Chuan Chen Sung-Hsin Kuo I-Rue Lai Kun-Huei Yeh Ming-Tsan Lin Hsiu-Po Wang Ann-Lii Cheng Jaw-Town Lin Chia-Tung Shun Ming-Shiang Wu Taiwan Gastrointestinal Disease and Helicobacter Consortium |
| author_facet | Kun-Feng Tsai Jyh-Ming Liou Mei-Jyh Chen Chien-Chuan Chen Sung-Hsin Kuo I-Rue Lai Kun-Huei Yeh Ming-Tsan Lin Hsiu-Po Wang Ann-Lii Cheng Jaw-Town Lin Chia-Tung Shun Ming-Shiang Wu Taiwan Gastrointestinal Disease and Helicobacter Consortium |
| author_sort | Kun-Feng Tsai |
| collection | DOAJ |
| description | <h4>Background</h4>Whether the characteristics and prognosis of gastric cancer (GC) are different in patients with and without Helicobacter pylori (HP) remains controversial. The definitions of HP status in patients with atrophic gastritis but negative tests for HP are heterogeneous. We aimed to assess the impact of HP on the prognosis of GC using different definitions.<h4>Methods</h4>From 1998 Nov to 2011 Jul, five hundred and sixty-seven consecutive patients with GC were included. HP status was determined by serology and histology. Patients with any positive test were defined as HP infection. Patients without HP infection whose serum pepsinogen (PG) I <70 ng/dl and PG I/II ratio < 3.0 were defined as atrophic gastritis and they were categorized into model 1: HP positive; model 2: HP negative; and model 3: exclusion of these patients.<h4>Results</h4>We found four characteristics of HP negative GC in comparison to HP positive GC: (1) higher proportion of the proximal tumor location (24.0%, P = 0.004), (2) more diffuse histologic type (56.1%, p = 0.008), (3) younger disease onset (58.02 years, p = 0.008) and (4) more stage IV disease (40.6%, p = 0.03). Patients with negative HP had worse overall survival (24.0% vs. 35.8%, p = 0.035). In Cox regression models, the negative HP status is an independent poor prognostic factor (HR: 1.34, CI:1.04-1.71, p = 0.019) in model 1, especially in stage I, II and III patients (HR: 1.62; CI:1.05-2.51,p = 0.026).<h4>Conclusion</h4>We found the distinct characteristics of HP negative GC. The prognosis of HP negative GC was poor. |
| format | Article |
| id | doaj-art-27e4c2ebe3904715a4f868be0fe8e0ab |
| institution | OA Journals |
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| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-27e4c2ebe3904715a4f868be0fe8e0ab2025-08-20T02:03:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e017094210.1371/journal.pone.0170942Distinct Clinicopathological Features and Prognosis of Helicobacter pylori Negative Gastric Cancer.Kun-Feng TsaiJyh-Ming LiouMei-Jyh ChenChien-Chuan ChenSung-Hsin KuoI-Rue LaiKun-Huei YehMing-Tsan LinHsiu-Po WangAnn-Lii ChengJaw-Town LinChia-Tung ShunMing-Shiang WuTaiwan Gastrointestinal Disease and Helicobacter Consortium<h4>Background</h4>Whether the characteristics and prognosis of gastric cancer (GC) are different in patients with and without Helicobacter pylori (HP) remains controversial. The definitions of HP status in patients with atrophic gastritis but negative tests for HP are heterogeneous. We aimed to assess the impact of HP on the prognosis of GC using different definitions.<h4>Methods</h4>From 1998 Nov to 2011 Jul, five hundred and sixty-seven consecutive patients with GC were included. HP status was determined by serology and histology. Patients with any positive test were defined as HP infection. Patients without HP infection whose serum pepsinogen (PG) I <70 ng/dl and PG I/II ratio < 3.0 were defined as atrophic gastritis and they were categorized into model 1: HP positive; model 2: HP negative; and model 3: exclusion of these patients.<h4>Results</h4>We found four characteristics of HP negative GC in comparison to HP positive GC: (1) higher proportion of the proximal tumor location (24.0%, P = 0.004), (2) more diffuse histologic type (56.1%, p = 0.008), (3) younger disease onset (58.02 years, p = 0.008) and (4) more stage IV disease (40.6%, p = 0.03). Patients with negative HP had worse overall survival (24.0% vs. 35.8%, p = 0.035). In Cox regression models, the negative HP status is an independent poor prognostic factor (HR: 1.34, CI:1.04-1.71, p = 0.019) in model 1, especially in stage I, II and III patients (HR: 1.62; CI:1.05-2.51,p = 0.026).<h4>Conclusion</h4>We found the distinct characteristics of HP negative GC. The prognosis of HP negative GC was poor.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170942&type=printable |
| spellingShingle | Kun-Feng Tsai Jyh-Ming Liou Mei-Jyh Chen Chien-Chuan Chen Sung-Hsin Kuo I-Rue Lai Kun-Huei Yeh Ming-Tsan Lin Hsiu-Po Wang Ann-Lii Cheng Jaw-Town Lin Chia-Tung Shun Ming-Shiang Wu Taiwan Gastrointestinal Disease and Helicobacter Consortium Distinct Clinicopathological Features and Prognosis of Helicobacter pylori Negative Gastric Cancer. PLoS ONE |
| title | Distinct Clinicopathological Features and Prognosis of Helicobacter pylori Negative Gastric Cancer. |
| title_full | Distinct Clinicopathological Features and Prognosis of Helicobacter pylori Negative Gastric Cancer. |
| title_fullStr | Distinct Clinicopathological Features and Prognosis of Helicobacter pylori Negative Gastric Cancer. |
| title_full_unstemmed | Distinct Clinicopathological Features and Prognosis of Helicobacter pylori Negative Gastric Cancer. |
| title_short | Distinct Clinicopathological Features and Prognosis of Helicobacter pylori Negative Gastric Cancer. |
| title_sort | distinct clinicopathological features and prognosis of helicobacter pylori negative gastric cancer |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170942&type=printable |
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