Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study
Abstract Plasma total cysteine (tCys) is strongly associated with fat mass in humans. Mesna lowers plasma tCys in a dose-dependent manner, but it is not known whether it interferes with metabolism of other amino acids or protein. In this Phase-1 study, we show that a single dose of mesna administere...
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| Format: | Article |
| Language: | English |
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Springer
2024-06-01
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| Series: | Amino Acids |
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| Online Access: | https://doi.org/10.1007/s00726-024-03398-2 |
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| author | Thomas Olsen Amany Elshorbagy Emma Stolt Anders Åsberg Hasse K. Zaré Nasser E. Bastani Helga Refsum Kjetil Retterstøl Kathrine J. Vinknes |
| author_facet | Thomas Olsen Amany Elshorbagy Emma Stolt Anders Åsberg Hasse K. Zaré Nasser E. Bastani Helga Refsum Kjetil Retterstøl Kathrine J. Vinknes |
| author_sort | Thomas Olsen |
| collection | DOAJ |
| description | Abstract Plasma total cysteine (tCys) is strongly associated with fat mass in humans. Mesna lowers plasma tCys in a dose-dependent manner, but it is not known whether it interferes with metabolism of other amino acids or protein. In this Phase-1 study, we show that a single dose of mesna administered at 400, 800, 1200 or 1600 mg to 6–7 individuals per dose only slightly affects amino acid profiles, with increases in plasma valine across dose levels. There were no effects of mesna on 3-methylhistidine, a marker of protein breakdown. |
| format | Article |
| id | doaj-art-27e46be8dff943ca913d83e0f0f165a8 |
| institution | OA Journals |
| issn | 1438-2199 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Amino Acids |
| spelling | doaj-art-27e46be8dff943ca913d83e0f0f165a82025-08-20T01:57:16ZengSpringerAmino Acids1438-21992024-06-015611510.1007/s00726-024-03398-2Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding studyThomas Olsen0Amany Elshorbagy1Emma Stolt2Anders Åsberg3Hasse K. Zaré4Nasser E. Bastani5Helga Refsum6Kjetil Retterstøl7Kathrine J. Vinknes8Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of OsloDepartment of Pharmacology, University of OxfordDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of OsloDepartment of Transplantation Medicine, Oslo University HospitalDepartment of Pharmacology, Oslo University HospitalDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of OsloDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of OsloDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of OsloDepartment of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of OsloAbstract Plasma total cysteine (tCys) is strongly associated with fat mass in humans. Mesna lowers plasma tCys in a dose-dependent manner, but it is not known whether it interferes with metabolism of other amino acids or protein. In this Phase-1 study, we show that a single dose of mesna administered at 400, 800, 1200 or 1600 mg to 6–7 individuals per dose only slightly affects amino acid profiles, with increases in plasma valine across dose levels. There were no effects of mesna on 3-methylhistidine, a marker of protein breakdown.https://doi.org/10.1007/s00726-024-03398-2MesnaTotal cysteineOverweightObesityAmino acid profile3-methylhistidine |
| spellingShingle | Thomas Olsen Amany Elshorbagy Emma Stolt Anders Åsberg Hasse K. Zaré Nasser E. Bastani Helga Refsum Kjetil Retterstøl Kathrine J. Vinknes Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study Amino Acids Mesna Total cysteine Overweight Obesity Amino acid profile 3-methylhistidine |
| title | Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study |
| title_full | Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study |
| title_fullStr | Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study |
| title_full_unstemmed | Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study |
| title_short | Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study |
| title_sort | acute effects of oral mesna administration on the full amino acid profile and 3 methylhistidine secondary results from the cylob dose finding study |
| topic | Mesna Total cysteine Overweight Obesity Amino acid profile 3-methylhistidine |
| url | https://doi.org/10.1007/s00726-024-03398-2 |
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