Rifampicin in Nontuberculous Mycobacterial Infections: Acute Kidney Injury with Hemoglobin Casts
Rifampicin is a key component of multidrug regimens not only for tuberculosis, but also nontuberculous mycobacterial infections (NTM) which are on the rise worldwide. Knowledge of the toxicity profile is important. Hepatotoxicity is a well-known side effect of Rifampicin necessitating regular liver...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2018/9321621 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554621655056384 |
|---|---|
| author | Rishi Kora Sergey V. Brodsky Tibor Nadasdy Dean Agra Anjali A. Satoskar |
| author_facet | Rishi Kora Sergey V. Brodsky Tibor Nadasdy Dean Agra Anjali A. Satoskar |
| author_sort | Rishi Kora |
| collection | DOAJ |
| description | Rifampicin is a key component of multidrug regimens not only for tuberculosis, but also nontuberculous mycobacterial infections (NTM) which are on the rise worldwide. Knowledge of the toxicity profile is important. Hepatotoxicity is a well-known side effect of Rifampicin necessitating regular liver function monitoring during therapy. Acute kidney injury (AKI) is a relatively rare complication, usually resulting from allergic interstitial nephritis (AIN). Rifampicin-induced intravascular hemolysis resulting in hemoglobinuria and AKI is even more uncommon, especially in Western countries with low prevalence of mycobacterial infections. Rifampicin-induced antibodies are implicated and this complication preferentially occurs during intermittent drug treatment protocols or when Rifampicin is restarted after a long drug-free interval. Awareness of this drug complication and its unique timing is important especially among emergency room physicians where patients with AKI may first present. It is equally important for nephrologists and pathologists. We describe one such case with detailed clinical course of the patient and interesting biopsy findings of ATN with intratubular hemoglobin casts. |
| format | Article |
| id | doaj-art-27e1f3d65c3745d7823d21b8ea3131ed |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-27e1f3d65c3745d7823d21b8ea3131ed2025-02-03T05:50:59ZengWileyCase Reports in Nephrology2090-66412090-665X2018-01-01201810.1155/2018/93216219321621Rifampicin in Nontuberculous Mycobacterial Infections: Acute Kidney Injury with Hemoglobin CastsRishi Kora0Sergey V. Brodsky1Tibor Nadasdy2Dean Agra3Anjali A. Satoskar4Mount Carmel West Hospital, Columbus, OH, USAOhio State University Wexner Medical Center, Columbus, OH, USAOhio State University Wexner Medical Center, Columbus, OH, USAColumbus Nephrology, Columbus, OH, USAOhio State University Wexner Medical Center, Columbus, OH, USARifampicin is a key component of multidrug regimens not only for tuberculosis, but also nontuberculous mycobacterial infections (NTM) which are on the rise worldwide. Knowledge of the toxicity profile is important. Hepatotoxicity is a well-known side effect of Rifampicin necessitating regular liver function monitoring during therapy. Acute kidney injury (AKI) is a relatively rare complication, usually resulting from allergic interstitial nephritis (AIN). Rifampicin-induced intravascular hemolysis resulting in hemoglobinuria and AKI is even more uncommon, especially in Western countries with low prevalence of mycobacterial infections. Rifampicin-induced antibodies are implicated and this complication preferentially occurs during intermittent drug treatment protocols or when Rifampicin is restarted after a long drug-free interval. Awareness of this drug complication and its unique timing is important especially among emergency room physicians where patients with AKI may first present. It is equally important for nephrologists and pathologists. We describe one such case with detailed clinical course of the patient and interesting biopsy findings of ATN with intratubular hemoglobin casts.http://dx.doi.org/10.1155/2018/9321621 |
| spellingShingle | Rishi Kora Sergey V. Brodsky Tibor Nadasdy Dean Agra Anjali A. Satoskar Rifampicin in Nontuberculous Mycobacterial Infections: Acute Kidney Injury with Hemoglobin Casts Case Reports in Nephrology |
| title | Rifampicin in Nontuberculous Mycobacterial Infections: Acute Kidney Injury with Hemoglobin Casts |
| title_full | Rifampicin in Nontuberculous Mycobacterial Infections: Acute Kidney Injury with Hemoglobin Casts |
| title_fullStr | Rifampicin in Nontuberculous Mycobacterial Infections: Acute Kidney Injury with Hemoglobin Casts |
| title_full_unstemmed | Rifampicin in Nontuberculous Mycobacterial Infections: Acute Kidney Injury with Hemoglobin Casts |
| title_short | Rifampicin in Nontuberculous Mycobacterial Infections: Acute Kidney Injury with Hemoglobin Casts |
| title_sort | rifampicin in nontuberculous mycobacterial infections acute kidney injury with hemoglobin casts |
| url | http://dx.doi.org/10.1155/2018/9321621 |
| work_keys_str_mv | AT rishikora rifampicininnontuberculousmycobacterialinfectionsacutekidneyinjurywithhemoglobincasts AT sergeyvbrodsky rifampicininnontuberculousmycobacterialinfectionsacutekidneyinjurywithhemoglobincasts AT tibornadasdy rifampicininnontuberculousmycobacterialinfectionsacutekidneyinjurywithhemoglobincasts AT deanagra rifampicininnontuberculousmycobacterialinfectionsacutekidneyinjurywithhemoglobincasts AT anjaliasatoskar rifampicininnontuberculousmycobacterialinfectionsacutekidneyinjurywithhemoglobincasts |