Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling
Abstract Induced pluripotent stem cells (iPSCs) are a powerful modeling system for medical discovery and translational research. To date, most studies have focused on the potential for iPSCs for regenerative medicine, drug discovery, and disease modeling. However, iPSCs are also a powerful modeling...
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| Format: | Article |
| Language: | English |
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Springer Nature
2022-10-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.202013260 |
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| author | Mark Chandy Detlef Obal Joseph C Wu |
| author_facet | Mark Chandy Detlef Obal Joseph C Wu |
| author_sort | Mark Chandy |
| collection | DOAJ |
| description | Abstract Induced pluripotent stem cells (iPSCs) are a powerful modeling system for medical discovery and translational research. To date, most studies have focused on the potential for iPSCs for regenerative medicine, drug discovery, and disease modeling. However, iPSCs are also a powerful modeling system to investigate the effects of environmental exposure on the cardiovascular system. With the emergence of e‐cigarettes, air pollution, marijuana use, opioids, and microplastics as novel cardiovascular risk factors, iPSCs have the potential for elucidating the effects of these toxins on the body using conventional two‐dimensional (2D) arrays and more advanced tissue engineering approaches with organoid and other three‐dimensional (3D) models. The effects of these environmental factors may be enhanced by genetic polymorphisms that make some individuals more susceptible to the effects of toxins. iPSC disease modeling may reveal important gene–environment interactions that exacerbate cardiovascular disease and predispose some individuals to adverse outcomes. Thus, iPSCs and gene‐editing techniques could play a pivotal role in elucidating the mechanisms of gene–environment interactions and understanding individual variability in susceptibility to environmental effects. |
| format | Article |
| id | doaj-art-27dbf42d090a415ea2dafc9b45874b0b |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-27dbf42d090a415ea2dafc9b45874b0b2025-08-20T04:03:02ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842022-10-01141111010.15252/emmm.202013260Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modelingMark Chandy0Detlef Obal1Joseph C Wu2Stanford Cardiovascular Institute, Stanford University School of MedicineStanford Cardiovascular Institute, Stanford University School of MedicineStanford Cardiovascular Institute, Stanford University School of MedicineAbstract Induced pluripotent stem cells (iPSCs) are a powerful modeling system for medical discovery and translational research. To date, most studies have focused on the potential for iPSCs for regenerative medicine, drug discovery, and disease modeling. However, iPSCs are also a powerful modeling system to investigate the effects of environmental exposure on the cardiovascular system. With the emergence of e‐cigarettes, air pollution, marijuana use, opioids, and microplastics as novel cardiovascular risk factors, iPSCs have the potential for elucidating the effects of these toxins on the body using conventional two‐dimensional (2D) arrays and more advanced tissue engineering approaches with organoid and other three‐dimensional (3D) models. The effects of these environmental factors may be enhanced by genetic polymorphisms that make some individuals more susceptible to the effects of toxins. iPSC disease modeling may reveal important gene–environment interactions that exacerbate cardiovascular disease and predispose some individuals to adverse outcomes. Thus, iPSCs and gene‐editing techniques could play a pivotal role in elucidating the mechanisms of gene–environment interactions and understanding individual variability in susceptibility to environmental effects.https://doi.org/10.15252/emmm.202013260cannabise‐cigarettesenvironmentiPSCopioids |
| spellingShingle | Mark Chandy Detlef Obal Joseph C Wu Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling EMBO Molecular Medicine cannabis e‐cigarettes environment iPSC opioids |
| title | Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling |
| title_full | Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling |
| title_fullStr | Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling |
| title_full_unstemmed | Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling |
| title_short | Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling |
| title_sort | elucidating effects of environmental exposure using human induced pluripotent stem cell disease modeling |
| topic | cannabis e‐cigarettes environment iPSC opioids |
| url | https://doi.org/10.15252/emmm.202013260 |
| work_keys_str_mv | AT markchandy elucidatingeffectsofenvironmentalexposureusinghumaninducedpluripotentstemcelldiseasemodeling AT detlefobal elucidatingeffectsofenvironmentalexposureusinghumaninducedpluripotentstemcelldiseasemodeling AT josephcwu elucidatingeffectsofenvironmentalexposureusinghumaninducedpluripotentstemcelldiseasemodeling |