Synergistic effects of lipoprotein (a) and fibrinogen on carotid plaque in patients with coronary artery disease
Abstract Background Elevated lipoprotein (a) [Lp (a)] and fibrinogen (Fib) are important factors contributing to the pathogenesis of atherosclerosis. Carotid plaque is a manifestation of carotid atherosclerosis, and previous studies have shown that Fib has a synergistic effect on Lp (a)-induced even...
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BMC
2025-02-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02351-7 |
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| author | Mengwei Wei Ziyang Liu Mengya Wei Sen Liu Menglong Jin Yaqi Zhou Qiqi Shao Ziyu Yi Subinuer Jureti Gulinigaer Maimaitituersun Zhenyan Fu |
| author_facet | Mengwei Wei Ziyang Liu Mengya Wei Sen Liu Menglong Jin Yaqi Zhou Qiqi Shao Ziyu Yi Subinuer Jureti Gulinigaer Maimaitituersun Zhenyan Fu |
| author_sort | Mengwei Wei |
| collection | DOAJ |
| description | Abstract Background Elevated lipoprotein (a) [Lp (a)] and fibrinogen (Fib) are important factors contributing to the pathogenesis of atherosclerosis. Carotid plaque is a manifestation of carotid atherosclerosis, and previous studies have shown that Fib has a synergistic effect on Lp (a)-induced events. However, the effect of the combined action of Lp (a) and fibrinogen on carotid plaque has not been elucidated. Methods This was a cross-sectional study that screened a total of 3913 patients who attended the First Affiliated Hospital of Xinjiang Medical University with confirmed diagnosis of coronary artery disease (CAD) and carotid ultrasonography during 2019–2024. General clinical information, physical examination data, and laboratory tests were collected from the patients. Based on the results of carotid ultrasonography, the patients were divided into a group with carotid plaque (1123 cases) and a group without carotid plaque (2790 cases). Multifactorial logistic regression analysis was used to explore the correlation between Lp (a) and Fib levels and carotid plaque and the interrelationship between them. Results A total of 3913 patients were included, including 2666 males and 1247 females, and the incidence of carotid plaque was 28.7%, with significant differences in Lp (a) and Fib levels between the two groups with and without carotid plaque (P < 0.05) and a significant interaction effect. Multiple logistic regression analysis showed that for every tenfold increase in plasma Lp (a) levels (i.e., an increase of one logarithmic unit), the incidence of carotid plaque could increase by about 32% or so. After stratified analysis for age and sex, it was observed that carotid plaque was significantly associated with plasma Lp (a) levels in men and in patients aged < 60 years (male: OR = 1.301, 95% CI 1.051–1.611; age < 60 years: OR = 1.373, 95% CI 1.076–1.753). Plasma Fib levels were associated with carotid plaque in patients of different sexes and age groups, and there was a significant synergistic effect of Lp (a) and Fib on carotid plaque (P interaction < 0.05). Conclusions Elevated levels of Lp (a) and Fib are independent risk factors for combined carotid plaque in patients with coronary artery disease, and there is a synergistic effect of both on carotid plaque. Therefore, plasma Lp (a) and Fib levels of patients should be focused on for better treatment of carotid plaque and prevention of ischemic stroke. |
| format | Article |
| id | doaj-art-27d9189c8f4e42dba802d902c81ee256 |
| institution | DOAJ |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-27d9189c8f4e42dba802d902c81ee2562025-08-20T03:04:01ZengBMCEuropean Journal of Medical Research2047-783X2025-02-013011910.1186/s40001-025-02351-7Synergistic effects of lipoprotein (a) and fibrinogen on carotid plaque in patients with coronary artery diseaseMengwei Wei0Ziyang Liu1Mengya Wei2Sen Liu3Menglong Jin4Yaqi Zhou5Qiqi Shao6Ziyu Yi7Subinuer Jureti8Gulinigaer Maimaitituersun9Zhenyan Fu10The First Affiliated Hospital of Xinjiang Medical UniversityThe First Affiliated Hospital of Xinjiang Medical UniversityHangzhou Medical CollegeThe First Affiliated Hospital of Xinjiang Medical UniversityThe First Affiliated Hospital of Xinjiang Medical UniversityThe First Affiliated Hospital of Xinjiang Medical UniversityThe First Affiliated Hospital of Xinjiang Medical UniversityThe First Affiliated Hospital of Xinjiang Medical UniversityThe First Affiliated Hospital of Xinjiang Medical UniversityThe First Affiliated Hospital of Xinjiang Medical UniversityThe First Affiliated Hospital of Xinjiang Medical UniversityAbstract Background Elevated lipoprotein (a) [Lp (a)] and fibrinogen (Fib) are important factors contributing to the pathogenesis of atherosclerosis. Carotid plaque is a manifestation of carotid atherosclerosis, and previous studies have shown that Fib has a synergistic effect on Lp (a)-induced events. However, the effect of the combined action of Lp (a) and fibrinogen on carotid plaque has not been elucidated. Methods This was a cross-sectional study that screened a total of 3913 patients who attended the First Affiliated Hospital of Xinjiang Medical University with confirmed diagnosis of coronary artery disease (CAD) and carotid ultrasonography during 2019–2024. General clinical information, physical examination data, and laboratory tests were collected from the patients. Based on the results of carotid ultrasonography, the patients were divided into a group with carotid plaque (1123 cases) and a group without carotid plaque (2790 cases). Multifactorial logistic regression analysis was used to explore the correlation between Lp (a) and Fib levels and carotid plaque and the interrelationship between them. Results A total of 3913 patients were included, including 2666 males and 1247 females, and the incidence of carotid plaque was 28.7%, with significant differences in Lp (a) and Fib levels between the two groups with and without carotid plaque (P < 0.05) and a significant interaction effect. Multiple logistic regression analysis showed that for every tenfold increase in plasma Lp (a) levels (i.e., an increase of one logarithmic unit), the incidence of carotid plaque could increase by about 32% or so. After stratified analysis for age and sex, it was observed that carotid plaque was significantly associated with plasma Lp (a) levels in men and in patients aged < 60 years (male: OR = 1.301, 95% CI 1.051–1.611; age < 60 years: OR = 1.373, 95% CI 1.076–1.753). Plasma Fib levels were associated with carotid plaque in patients of different sexes and age groups, and there was a significant synergistic effect of Lp (a) and Fib on carotid plaque (P interaction < 0.05). Conclusions Elevated levels of Lp (a) and Fib are independent risk factors for combined carotid plaque in patients with coronary artery disease, and there is a synergistic effect of both on carotid plaque. Therefore, plasma Lp (a) and Fib levels of patients should be focused on for better treatment of carotid plaque and prevention of ischemic stroke.https://doi.org/10.1186/s40001-025-02351-7Lipoprotein (a)FibrinogenCarotid plaqueCoronary artery diseaseDyslipidemiaIschemic stroke |
| spellingShingle | Mengwei Wei Ziyang Liu Mengya Wei Sen Liu Menglong Jin Yaqi Zhou Qiqi Shao Ziyu Yi Subinuer Jureti Gulinigaer Maimaitituersun Zhenyan Fu Synergistic effects of lipoprotein (a) and fibrinogen on carotid plaque in patients with coronary artery disease European Journal of Medical Research Lipoprotein (a) Fibrinogen Carotid plaque Coronary artery disease Dyslipidemia Ischemic stroke |
| title | Synergistic effects of lipoprotein (a) and fibrinogen on carotid plaque in patients with coronary artery disease |
| title_full | Synergistic effects of lipoprotein (a) and fibrinogen on carotid plaque in patients with coronary artery disease |
| title_fullStr | Synergistic effects of lipoprotein (a) and fibrinogen on carotid plaque in patients with coronary artery disease |
| title_full_unstemmed | Synergistic effects of lipoprotein (a) and fibrinogen on carotid plaque in patients with coronary artery disease |
| title_short | Synergistic effects of lipoprotein (a) and fibrinogen on carotid plaque in patients with coronary artery disease |
| title_sort | synergistic effects of lipoprotein a and fibrinogen on carotid plaque in patients with coronary artery disease |
| topic | Lipoprotein (a) Fibrinogen Carotid plaque Coronary artery disease Dyslipidemia Ischemic stroke |
| url | https://doi.org/10.1186/s40001-025-02351-7 |
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