Characteristics and correlations of sleep disorders in patients with relapsing–remitting multiple sclerosis in China: a cross-sectional study
BackgroundSleep disorders are a major but overlooked symptom in patients with multiple sclerosis (MS).ObjectivesThis article aims to investigate the characteristics of sleep disorders in patients with relapsing–remitting multiple sclerosis (RRMS) and to analyze the correlations between sleep disorde...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1608802/full |
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| author | Rongrong Wang Tengteng Zhang Han Wang Yao Ren Runze Zhao Gaopan Zhang Guoxun Zhang Xiongfei Zhao |
| author_facet | Rongrong Wang Tengteng Zhang Han Wang Yao Ren Runze Zhao Gaopan Zhang Guoxun Zhang Xiongfei Zhao |
| author_sort | Rongrong Wang |
| collection | DOAJ |
| description | BackgroundSleep disorders are a major but overlooked symptom in patients with multiple sclerosis (MS).ObjectivesThis article aims to investigate the characteristics of sleep disorders in patients with relapsing–remitting multiple sclerosis (RRMS) and to analyze the correlations between sleep disorders in RRMS and anxiety, depression, fatigue, and cognitive impairment.MethodsA total of 35 patients with RRMS and 35 controls were included, and both groups underwent assessments for sleep, anxiety, depression, fatigue, and cognitive function.ResultsThe RRMS group and the control group showed significant differences in Pittsburgh Sleep Quality Index (PSQI), Athens Insomnia Scale (AIS), Insomnia Severity Index (ISI), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Modified Fatigue Impact Scale (MFIS), and Montreal Cognitive Assessment (MoCA). The group with poor sleep quality (PSQI > 5) had significantly higher scores on the AIS, ISI, HAMA, and HAMD Scale compared to the group with good sleep quality (p = 0.036, p < 0.001, p = 0.036, p = 0.054). The PSQI showed a negative correlation with disease duration; the PSQI showed a positive correlation with HAMA, HAMD, and Activities of Daily Living (ADL); AIS, ISI, and Sleep Hygiene Awareness and Practice Scale (SHAPS) all demonstrated significant positive correlations with MFIS, HAMA, and HAMD; Dysfunctional Beliefs and Attitudes about Sleep Scale (DBAS) showed a negative correlation with HAMA and HAMD.ConclusionSleep disorders, fatigue, anxiety, depression, and cognitive impairments are more likely to occur in patients with RRMS; there is a certain correlation between PSQI, AIS, ISI, SHAPS, and DBAS scores in the RRMS group and fatigue, anxiety, and depression. |
| format | Article |
| id | doaj-art-27d032e719fe4fdb85f482ce7e2b367c |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-27d032e719fe4fdb85f482ce7e2b367c2025-08-20T04:01:18ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-07-011610.3389/fneur.2025.16088021608802Characteristics and correlations of sleep disorders in patients with relapsing–remitting multiple sclerosis in China: a cross-sectional studyRongrong Wang0Tengteng Zhang1Han Wang2Yao Ren3Runze Zhao4Gaopan Zhang5Guoxun Zhang6Xiongfei Zhao7Xianyang Hospital of Yan 'an University, Xianyang, ChinaXianyang Hospital of Yan 'an University, Xianyang, ChinaXianyang Hospital of Yan 'an University, Xianyang, ChinaXianyang Hospital of Yan 'an University, Xianyang, ChinaXijing Hospital, Air Force Medical University, Xi’an, ChinaXianyang Hospital of Yan 'an University, Xianyang, ChinaXianyang Hospital of Yan 'an University, Xianyang, ChinaXianyang Hospital of Yan 'an University, Xianyang, ChinaBackgroundSleep disorders are a major but overlooked symptom in patients with multiple sclerosis (MS).ObjectivesThis article aims to investigate the characteristics of sleep disorders in patients with relapsing–remitting multiple sclerosis (RRMS) and to analyze the correlations between sleep disorders in RRMS and anxiety, depression, fatigue, and cognitive impairment.MethodsA total of 35 patients with RRMS and 35 controls were included, and both groups underwent assessments for sleep, anxiety, depression, fatigue, and cognitive function.ResultsThe RRMS group and the control group showed significant differences in Pittsburgh Sleep Quality Index (PSQI), Athens Insomnia Scale (AIS), Insomnia Severity Index (ISI), Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Modified Fatigue Impact Scale (MFIS), and Montreal Cognitive Assessment (MoCA). The group with poor sleep quality (PSQI > 5) had significantly higher scores on the AIS, ISI, HAMA, and HAMD Scale compared to the group with good sleep quality (p = 0.036, p < 0.001, p = 0.036, p = 0.054). The PSQI showed a negative correlation with disease duration; the PSQI showed a positive correlation with HAMA, HAMD, and Activities of Daily Living (ADL); AIS, ISI, and Sleep Hygiene Awareness and Practice Scale (SHAPS) all demonstrated significant positive correlations with MFIS, HAMA, and HAMD; Dysfunctional Beliefs and Attitudes about Sleep Scale (DBAS) showed a negative correlation with HAMA and HAMD.ConclusionSleep disorders, fatigue, anxiety, depression, and cognitive impairments are more likely to occur in patients with RRMS; there is a certain correlation between PSQI, AIS, ISI, SHAPS, and DBAS scores in the RRMS group and fatigue, anxiety, and depression.https://www.frontiersin.org/articles/10.3389/fneur.2025.1608802/fullrelapsing–remitting multiple sclerosissleep disordersfatigueanxietydepressioncognitive impairment |
| spellingShingle | Rongrong Wang Tengteng Zhang Han Wang Yao Ren Runze Zhao Gaopan Zhang Guoxun Zhang Xiongfei Zhao Characteristics and correlations of sleep disorders in patients with relapsing–remitting multiple sclerosis in China: a cross-sectional study Frontiers in Neurology relapsing–remitting multiple sclerosis sleep disorders fatigue anxiety depression cognitive impairment |
| title | Characteristics and correlations of sleep disorders in patients with relapsing–remitting multiple sclerosis in China: a cross-sectional study |
| title_full | Characteristics and correlations of sleep disorders in patients with relapsing–remitting multiple sclerosis in China: a cross-sectional study |
| title_fullStr | Characteristics and correlations of sleep disorders in patients with relapsing–remitting multiple sclerosis in China: a cross-sectional study |
| title_full_unstemmed | Characteristics and correlations of sleep disorders in patients with relapsing–remitting multiple sclerosis in China: a cross-sectional study |
| title_short | Characteristics and correlations of sleep disorders in patients with relapsing–remitting multiple sclerosis in China: a cross-sectional study |
| title_sort | characteristics and correlations of sleep disorders in patients with relapsing remitting multiple sclerosis in china a cross sectional study |
| topic | relapsing–remitting multiple sclerosis sleep disorders fatigue anxiety depression cognitive impairment |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1608802/full |
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