The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome
Abstract Objective This study aimed to examine the association of rs7041 polymorphism with PCOS, as well as infertility and recurrent pregnancy loss (RPL) in PCOS patients. Results Genotype analysis showed that the GT genotype and the T allele of the rs7041 polymorphism were associated with increase...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
|
| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13104-025-07312-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850105451789680640 |
|---|---|
| author | Hediyeh Hamidi Asma Kheirollahi Akram Vatannejad |
| author_facet | Hediyeh Hamidi Asma Kheirollahi Akram Vatannejad |
| author_sort | Hediyeh Hamidi |
| collection | DOAJ |
| description | Abstract Objective This study aimed to examine the association of rs7041 polymorphism with PCOS, as well as infertility and recurrent pregnancy loss (RPL) in PCOS patients. Results Genotype analysis showed that the GT genotype and the T allele of the rs7041 polymorphism were associated with increased odds of PCOS. (OR: 2.8 95% CI [1.48–5.33], p = 0.002, and OR: 2.27 95% CI [1.2–4.28], p = 0.01, respectively). Furthermore, the GT genotype and T allele of the rs7041 polymorphism were associated with increased odds of infertility in women with PCOS. (OR: 40.55 95% CI [5.34–307.7], p < 0.0001, and OR: 30.667 95% CI [4.05-232.19], p = 0.001, respectively). Conversely, no significant association was observed between genotypes and RPL in women with PCOS. Luteinizing hormone (LH) levels were significantly higher in individuals with the T allele compared to those with the G allele. |
| format | Article |
| id | doaj-art-27cfea00e5a64814a1b147d5fc0b20d8 |
| institution | OA Journals |
| issn | 1756-0500 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj-art-27cfea00e5a64814a1b147d5fc0b20d82025-08-20T02:39:04ZengBMCBMC Research Notes1756-05002025-05-011811810.1186/s13104-025-07312-1The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndromeHediyeh Hamidi0Asma Kheirollahi1Akram Vatannejad2Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of TehranDepartment of Comparative Biosciences, Faculty of Veterinary Medicine, University of TehranDepartment of Comparative Biosciences, Faculty of Veterinary Medicine, University of TehranAbstract Objective This study aimed to examine the association of rs7041 polymorphism with PCOS, as well as infertility and recurrent pregnancy loss (RPL) in PCOS patients. Results Genotype analysis showed that the GT genotype and the T allele of the rs7041 polymorphism were associated with increased odds of PCOS. (OR: 2.8 95% CI [1.48–5.33], p = 0.002, and OR: 2.27 95% CI [1.2–4.28], p = 0.01, respectively). Furthermore, the GT genotype and T allele of the rs7041 polymorphism were associated with increased odds of infertility in women with PCOS. (OR: 40.55 95% CI [5.34–307.7], p < 0.0001, and OR: 30.667 95% CI [4.05-232.19], p = 0.001, respectively). Conversely, no significant association was observed between genotypes and RPL in women with PCOS. Luteinizing hormone (LH) levels were significantly higher in individuals with the T allele compared to those with the G allele.https://doi.org/10.1186/s13104-025-07312-1Recurrent pregnancy lossVitamin D binding proteinInfertilityPolycystic ovary syndromePolymorphism |
| spellingShingle | Hediyeh Hamidi Asma Kheirollahi Akram Vatannejad The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome BMC Research Notes Recurrent pregnancy loss Vitamin D binding protein Infertility Polycystic ovary syndrome Polymorphism |
| title | The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome |
| title_full | The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome |
| title_fullStr | The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome |
| title_full_unstemmed | The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome |
| title_short | The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome |
| title_sort | association of rs7041 polymorphism with infertility and recurrent pregnancy loss in iranian women with polycystic ovary syndrome |
| topic | Recurrent pregnancy loss Vitamin D binding protein Infertility Polycystic ovary syndrome Polymorphism |
| url | https://doi.org/10.1186/s13104-025-07312-1 |
| work_keys_str_mv | AT hediyehhamidi theassociationofrs7041polymorphismwithinfertilityandrecurrentpregnancylossiniranianwomenwithpolycysticovarysyndrome AT asmakheirollahi theassociationofrs7041polymorphismwithinfertilityandrecurrentpregnancylossiniranianwomenwithpolycysticovarysyndrome AT akramvatannejad theassociationofrs7041polymorphismwithinfertilityandrecurrentpregnancylossiniranianwomenwithpolycysticovarysyndrome AT hediyehhamidi associationofrs7041polymorphismwithinfertilityandrecurrentpregnancylossiniranianwomenwithpolycysticovarysyndrome AT asmakheirollahi associationofrs7041polymorphismwithinfertilityandrecurrentpregnancylossiniranianwomenwithpolycysticovarysyndrome AT akramvatannejad associationofrs7041polymorphismwithinfertilityandrecurrentpregnancylossiniranianwomenwithpolycysticovarysyndrome |