Obesity reprograms the normal pancreas and pancreatic cancer microbiome in mice and humans

Obesity reprograms the normal pancreas and pancreatic cancer microbiome in mice and humans

IntroductionPancreatic ductal adenocarcinoma (PDAC) is an aggressive form of pancreatic cancer, with overall 5-year survival rates of about 8%. Obesity (and underlying metabolic dysfunction) is estimated to account for up to 50% of all PDACs. Microbial communities can be modulated by obesity and exe...

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Bibliographic Details
Main Authors: Raquel Santana da Cruz, Shravanthy Suguru, Sara P. C. Paiva, Ijeoma Nwugwo, Bhaskar Kallakury, Benjamin A. Weinberg, Katherine L. Cook, Sonia de Assis
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Microbiomes
Subjects:
PDAC
pancreatic ductal adenocarcinoma
obesity
microbiome
mouse
human
Online Access:https://www.frontiersin.org/articles/10.3389/frmbi.2025.1543144/full
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