Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic morphine

Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic morphine

The therapeutic benefits of opioids are compromised by the development of analgesic tolerance, which necessitates higher dosing for pain management thereby increasing the liability for drug dependence and addiction. Rodent models indicate opposing roles of the gut microbiota in tolerance: morphine-i...

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Bibliographic Details
Main Authors: Izabella Sall, Randi Foxall, Lindsey Felth, Soren Maret, Zachary Rosa, Anirudh Gaur, Jennifer Calawa, Nadia Pavlik, Jennifer L. Whistler, Cheryl A. Whistler
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Microbiota
opioid
analgesic tolerance
butyrate
short-chain fatty acid
inflammation
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2024.2446423
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