A common TBP-binding site mutation elevates fetal hemoglobin levels by competitive globin switching change in β-thalassemia

A common TBP-binding site mutation elevates fetal hemoglobin levels by competitive globin switching change in β-thalassemia

Abstract: β-Thalassemia is a common monogenic disorder caused by genetic defects in β-globin genes (HBB) resulting in imbalanced synthesis of α-/β-globin and ineffective erythropoiesis. It has been well documented that patients with β-thalassemia, or even carriers, mostly experience reactivation of...

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Bibliographic Details
Main Authors:	Mengyang Song, Xiaolei Wei, Hualei Luo, Jueheng Wang, Yuhua Ye, Lang Qin, Chao Niu, Yong Long, Xingmin Wang, Congwen Shao, Miao Yu, Feng Gu, Xinhua Zhang, Xiangmin Xu
Format:	Article
Language:	English
Published:	Elsevier 2025-07-01
Series:	Blood Advances
Online Access:	http://www.sciencedirect.com/science/article/pii/S2473952925002095
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