Associations of environmental pollution with pro-oxidant, antioxidant and inflammatory markers in pregnant mothers and newborns
The aim of the study was to analyze the variables that modify the levels of oxidative DNA damage and lipid peroxidation in non-smoking mothers and their newborns from environmentally distinct localities of the Czech Republic: Ceske Budejovice (CB, an agricultural region) and Karvina (an industrial r...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Toxicology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/ftox.2025.1572486/full |
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| author | Antonin Ambroz Jiri Klema Andrea Rossnerova Alena Milcova Anna Pastorkova Jana Pulkrabova Ondrej Parizek Veronika Gomersall Tomas Gramblicka Jaroslav Zelenka Tomas Ruml Nikola Vrzackova Milos Veleminsky Milos Veleminsky Newroz Hasan Jan Topinka Radim J. Sram Pavel Rossner |
| author_facet | Antonin Ambroz Jiri Klema Andrea Rossnerova Alena Milcova Anna Pastorkova Jana Pulkrabova Ondrej Parizek Veronika Gomersall Tomas Gramblicka Jaroslav Zelenka Tomas Ruml Nikola Vrzackova Milos Veleminsky Milos Veleminsky Newroz Hasan Jan Topinka Radim J. Sram Pavel Rossner |
| author_sort | Antonin Ambroz |
| collection | DOAJ |
| description | The aim of the study was to analyze the variables that modify the levels of oxidative DNA damage and lipid peroxidation in non-smoking mothers and their newborns from environmentally distinct localities of the Czech Republic: Ceske Budejovice (CB, an agricultural region) and Karvina (an industrial region). Personal, socio-economic and medical data, concentrations of particulate matter of aerodynamic diameter < 2.5 µm (PM2.5) and benzo[a]pyrene (B[a]P) in the ambient air, the activities of antioxidant mechanisms (superoxide dismutase, catalase, glutathione peroxidase) and antioxidant capacity), the levels of pro-inflammatory cytokines, the concentrations of persistent organic pollutants (POPs) in blood plasma/cord blood plasma and urinary levels of polycyclic aromatic hydrocarbons metabolites (OH-PAHs) were investigated as parameters potentially affecting the markers of DNA oxidation (8-oxo-7,8-dihydro-2′-deoxyguanosine, 8-oxodG) and lipid peroxidation (15-F2t-isoprostane, 15-F2t-IsoP). Significantly higher levels of POPs were detected in the plasma of mothers/newborns from CB (p < 0.001), while increased external levels of B[a]P and PM2.5, confirmed by analyzing urinary OH-PAHs, were found in Karvina subjects (p < 0.001). In mothers, multivariate analysis showed no significant difference in oxidative stress markers (15-F2t-IsoP, 8-oxodG) between the two localities. The analysis further revealed that neither in CB nor, unexpectedly, in Karvina, did PAH exposure affect maternal lipid peroxidation. Significant associations between OH-PAHs and 15-F2t-IsoP or 8-oxodG were observed only in newborns. In addition, multivariate analyses revealed a borderline significant association between locality and 8-oxodG in the urine of all newborns (p = 0.05). In conclusion, not only the maternal exposure of PAHs but also some POPs can negatively affect oxidative stress status in the early-life of newborns. |
| format | Article |
| id | doaj-art-27c0366ae950465e810da8ff33bb4f06 |
| institution | DOAJ |
| issn | 2673-3080 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Toxicology |
| spelling | doaj-art-27c0366ae950465e810da8ff33bb4f062025-08-20T02:43:15ZengFrontiers Media S.A.Frontiers in Toxicology2673-30802025-04-01710.3389/ftox.2025.15724861572486Associations of environmental pollution with pro-oxidant, antioxidant and inflammatory markers in pregnant mothers and newbornsAntonin Ambroz0Jiri Klema1Andrea Rossnerova2Alena Milcova3Anna Pastorkova4Jana Pulkrabova5Ondrej Parizek6Veronika Gomersall7Tomas Gramblicka8Jaroslav Zelenka9Tomas Ruml10Nikola Vrzackova11Milos Veleminsky12Milos Veleminsky13Newroz Hasan14Jan Topinka15Radim J. Sram16Pavel Rossner17Department of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Prague, CzechiaDepartment of Computer Science, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, CzechiaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Prague, CzechiaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Prague, CzechiaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Prague, CzechiaDepartment of Food Analysis and Nutrition, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Prague, CzechiaDepartment of Food Analysis and Nutrition, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Prague, CzechiaDepartment of Food Analysis and Nutrition, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Prague, CzechiaDepartment of Food Analysis and Nutrition, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Prague, CzechiaDepartment of Biochemistry and Microbiology, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Prague, CzechiaDepartment of Biochemistry and Microbiology, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Prague, CzechiaDepartment of Biochemistry and Microbiology, Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Prague, CzechiaFaculty of Health and Social Sciences, University of South Bohemia, Ceske Budejovice, CzechiaDepartment of Obstetrics and Gynaecology, Hospital Ceske Budejovice, Ceske Budejovice, CzechiaDepartment of Obstetrics and Gynaecology, Hospital Karvina-Raj, Karvina, CzechiaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Prague, CzechiaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Prague, CzechiaDepartment of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Prague, CzechiaThe aim of the study was to analyze the variables that modify the levels of oxidative DNA damage and lipid peroxidation in non-smoking mothers and their newborns from environmentally distinct localities of the Czech Republic: Ceske Budejovice (CB, an agricultural region) and Karvina (an industrial region). Personal, socio-economic and medical data, concentrations of particulate matter of aerodynamic diameter < 2.5 µm (PM2.5) and benzo[a]pyrene (B[a]P) in the ambient air, the activities of antioxidant mechanisms (superoxide dismutase, catalase, glutathione peroxidase) and antioxidant capacity), the levels of pro-inflammatory cytokines, the concentrations of persistent organic pollutants (POPs) in blood plasma/cord blood plasma and urinary levels of polycyclic aromatic hydrocarbons metabolites (OH-PAHs) were investigated as parameters potentially affecting the markers of DNA oxidation (8-oxo-7,8-dihydro-2′-deoxyguanosine, 8-oxodG) and lipid peroxidation (15-F2t-isoprostane, 15-F2t-IsoP). Significantly higher levels of POPs were detected in the plasma of mothers/newborns from CB (p < 0.001), while increased external levels of B[a]P and PM2.5, confirmed by analyzing urinary OH-PAHs, were found in Karvina subjects (p < 0.001). In mothers, multivariate analysis showed no significant difference in oxidative stress markers (15-F2t-IsoP, 8-oxodG) between the two localities. The analysis further revealed that neither in CB nor, unexpectedly, in Karvina, did PAH exposure affect maternal lipid peroxidation. Significant associations between OH-PAHs and 15-F2t-IsoP or 8-oxodG were observed only in newborns. In addition, multivariate analyses revealed a borderline significant association between locality and 8-oxodG in the urine of all newborns (p = 0.05). In conclusion, not only the maternal exposure of PAHs but also some POPs can negatively affect oxidative stress status in the early-life of newborns.https://www.frontiersin.org/articles/10.3389/ftox.2025.1572486/fullenvironmental pollutionmaternal exposure to newbornoxidative DNA damagelipid peroxidationantioxidant response and inflammatory cytokines |
| spellingShingle | Antonin Ambroz Jiri Klema Andrea Rossnerova Alena Milcova Anna Pastorkova Jana Pulkrabova Ondrej Parizek Veronika Gomersall Tomas Gramblicka Jaroslav Zelenka Tomas Ruml Nikola Vrzackova Milos Veleminsky Milos Veleminsky Newroz Hasan Jan Topinka Radim J. Sram Pavel Rossner Associations of environmental pollution with pro-oxidant, antioxidant and inflammatory markers in pregnant mothers and newborns Frontiers in Toxicology environmental pollution maternal exposure to newborn oxidative DNA damage lipid peroxidation antioxidant response and inflammatory cytokines |
| title | Associations of environmental pollution with pro-oxidant, antioxidant and inflammatory markers in pregnant mothers and newborns |
| title_full | Associations of environmental pollution with pro-oxidant, antioxidant and inflammatory markers in pregnant mothers and newborns |
| title_fullStr | Associations of environmental pollution with pro-oxidant, antioxidant and inflammatory markers in pregnant mothers and newborns |
| title_full_unstemmed | Associations of environmental pollution with pro-oxidant, antioxidant and inflammatory markers in pregnant mothers and newborns |
| title_short | Associations of environmental pollution with pro-oxidant, antioxidant and inflammatory markers in pregnant mothers and newborns |
| title_sort | associations of environmental pollution with pro oxidant antioxidant and inflammatory markers in pregnant mothers and newborns |
| topic | environmental pollution maternal exposure to newborn oxidative DNA damage lipid peroxidation antioxidant response and inflammatory cytokines |
| url | https://www.frontiersin.org/articles/10.3389/ftox.2025.1572486/full |
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