Cathepsin B in urological tumors: unraveling its role and therapeutic potential
Abstract Cathepsin B(CTSB) is a key protease within the lysosomal protease family and is recognized as a tumor-promoting factor that exerts a substantial impact on cancer progression. It plays a critical role in the initiation, proliferation, metastasis, and angiogenesis of cancer, significantly adv...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-05-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-025-02552-w |
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| _version_ | 1849729035978932224 |
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| author | Zhaojie Yan Guansong Zheng Junrong Zou Xiaofeng Zou Keqiang Chai Guoxi Zhang |
| author_facet | Zhaojie Yan Guansong Zheng Junrong Zou Xiaofeng Zou Keqiang Chai Guoxi Zhang |
| author_sort | Zhaojie Yan |
| collection | DOAJ |
| description | Abstract Cathepsin B(CTSB) is a key protease within the lysosomal protease family and is recognized as a tumor-promoting factor that exerts a substantial impact on cancer progression. It plays a critical role in the initiation, proliferation, metastasis, and angiogenesis of cancer, significantly advancing the disease. This review offers a concise overview of the structure and biological functions of CTSB, clarifying its relationship with cancer and the role it plays in the disease's progression. Additionally, we discuss the association between CTSB and several common malignant tumors of the urinary system, highlighting its potential role and clinical significance within these tumors, as well as the challenges that remain. |
| format | Article |
| id | doaj-art-27bc6d63a3384fe9b7d2025c3be7f97d |
| institution | DOAJ |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-27bc6d63a3384fe9b7d2025c3be7f97d2025-08-20T03:09:20ZengSpringerDiscover Oncology2730-60112025-05-0116111410.1007/s12672-025-02552-wCathepsin B in urological tumors: unraveling its role and therapeutic potentialZhaojie Yan0Guansong Zheng1Junrong Zou2Xiaofeng Zou3Keqiang Chai4Guoxi Zhang5First Clinical College, Gannan Medical UniversityFirst Clinical College, Gannan Medical UniversityDepartment of Urology, First Affiliated Hospital of Gannan Medical UniversityDepartment of Urology, First Affiliated Hospital of Gannan Medical UniversityDepartment of Urology, Third Affiliated Hospital of Gansu University of Chinese MedicineDepartment of Urology, First Affiliated Hospital of Gannan Medical UniversityAbstract Cathepsin B(CTSB) is a key protease within the lysosomal protease family and is recognized as a tumor-promoting factor that exerts a substantial impact on cancer progression. It plays a critical role in the initiation, proliferation, metastasis, and angiogenesis of cancer, significantly advancing the disease. This review offers a concise overview of the structure and biological functions of CTSB, clarifying its relationship with cancer and the role it plays in the disease's progression. Additionally, we discuss the association between CTSB and several common malignant tumors of the urinary system, highlighting its potential role and clinical significance within these tumors, as well as the challenges that remain.https://doi.org/10.1007/s12672-025-02552-wCathepsin BProstate cancerBladder cancerRenal cell carcinomaTumor drug resistance |
| spellingShingle | Zhaojie Yan Guansong Zheng Junrong Zou Xiaofeng Zou Keqiang Chai Guoxi Zhang Cathepsin B in urological tumors: unraveling its role and therapeutic potential Discover Oncology Cathepsin B Prostate cancer Bladder cancer Renal cell carcinoma Tumor drug resistance |
| title | Cathepsin B in urological tumors: unraveling its role and therapeutic potential |
| title_full | Cathepsin B in urological tumors: unraveling its role and therapeutic potential |
| title_fullStr | Cathepsin B in urological tumors: unraveling its role and therapeutic potential |
| title_full_unstemmed | Cathepsin B in urological tumors: unraveling its role and therapeutic potential |
| title_short | Cathepsin B in urological tumors: unraveling its role and therapeutic potential |
| title_sort | cathepsin b in urological tumors unraveling its role and therapeutic potential |
| topic | Cathepsin B Prostate cancer Bladder cancer Renal cell carcinoma Tumor drug resistance |
| url | https://doi.org/10.1007/s12672-025-02552-w |
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