Greenness assessment of a molecularly imprinted polymeric sensor based on a bio-inspired polymer
Abstract Methyldopa, a synthesized dopamine substitute with phenolic, amine, and carboxylic groups, was used to create a selective molecular imprinted polymer (MIP) for detecting formoterol fumarate dihydrate (FFD), a long-acting beta2-agonist for asthma and COPD. The bio-inspired polymer (MD) was e...
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| Format: | Article |
| Language: | English |
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BMC
2024-10-01
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| Series: | BMC Chemistry |
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| Online Access: | https://doi.org/10.1186/s13065-024-01313-0 |
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| author | Hamees A. Adawy Maha A. Hegazy Samah S. Saad Amr M. Bekhet Shereen A. Boltia |
| author_facet | Hamees A. Adawy Maha A. Hegazy Samah S. Saad Amr M. Bekhet Shereen A. Boltia |
| author_sort | Hamees A. Adawy |
| collection | DOAJ |
| description | Abstract Methyldopa, a synthesized dopamine substitute with phenolic, amine, and carboxylic groups, was used to create a selective molecular imprinted polymer (MIP) for detecting formoterol fumarate dihydrate (FFD), a long-acting beta2-agonist for asthma and COPD. The bio-inspired polymer (MD) was electro-grafted onto a pencil graphite electrode (PGE) using cyclic voltammetry in a phosphate buffer (pH 6.5). An indirect method involving a redox probe (ferrocyanide/ferricyanide) and differential pulse voltammetry measured FFD binding to the MIP’s 3D cavities. The sensor showed a linear response range from 1 × 10⁻⁹ M to 2 × 10⁻¹⁰ M, with a detection limit of 1.7 × 10⁻¹¹ M. The polymethyldopa (PMD) and FFD interaction was assessed by UV spectroscopy, and the method was validated per ICH guidelines. Green analytical approaches, including RGB and GAPI, were also implemented. The goal was to use advances in molecularly imprinted polymers to develop a more precise and selective electrochemical sensor for FFD quantification. |
| format | Article |
| id | doaj-art-27b1a911ecfd4e2ab799dd7e7dfe1127 |
| institution | OA Journals |
| issn | 2661-801X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Chemistry |
| spelling | doaj-art-27b1a911ecfd4e2ab799dd7e7dfe11272025-08-20T02:11:23ZengBMCBMC Chemistry2661-801X2024-10-0118111410.1186/s13065-024-01313-0Greenness assessment of a molecularly imprinted polymeric sensor based on a bio-inspired polymerHamees A. Adawy0Maha A. Hegazy1Samah S. Saad2Amr M. Bekhet3Shereen A. Boltia4Pharmaceutical Analytical Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science & TechnologyPharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in EgyptPharmaceutical Analytical Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science & TechnologyAnalytical Chemistry Department, Faculty of Pharmacy, Cairo UniversityAnalytical Chemistry Department, Faculty of Pharmacy, Cairo UniversityAbstract Methyldopa, a synthesized dopamine substitute with phenolic, amine, and carboxylic groups, was used to create a selective molecular imprinted polymer (MIP) for detecting formoterol fumarate dihydrate (FFD), a long-acting beta2-agonist for asthma and COPD. The bio-inspired polymer (MD) was electro-grafted onto a pencil graphite electrode (PGE) using cyclic voltammetry in a phosphate buffer (pH 6.5). An indirect method involving a redox probe (ferrocyanide/ferricyanide) and differential pulse voltammetry measured FFD binding to the MIP’s 3D cavities. The sensor showed a linear response range from 1 × 10⁻⁹ M to 2 × 10⁻¹⁰ M, with a detection limit of 1.7 × 10⁻¹¹ M. The polymethyldopa (PMD) and FFD interaction was assessed by UV spectroscopy, and the method was validated per ICH guidelines. Green analytical approaches, including RGB and GAPI, were also implemented. The goal was to use advances in molecularly imprinted polymers to develop a more precise and selective electrochemical sensor for FFD quantification.https://doi.org/10.1186/s13065-024-01313-0Mussel-inspired polymersPoly (methyldopa)FormoterolMolecularly-imprinted polymersElectrochemical sensors, Green analytical procedure index, red green blue model |
| spellingShingle | Hamees A. Adawy Maha A. Hegazy Samah S. Saad Amr M. Bekhet Shereen A. Boltia Greenness assessment of a molecularly imprinted polymeric sensor based on a bio-inspired polymer BMC Chemistry Mussel-inspired polymers Poly (methyldopa) Formoterol Molecularly-imprinted polymers Electrochemical sensors, Green analytical procedure index, red green blue model |
| title | Greenness assessment of a molecularly imprinted polymeric sensor based on a bio-inspired polymer |
| title_full | Greenness assessment of a molecularly imprinted polymeric sensor based on a bio-inspired polymer |
| title_fullStr | Greenness assessment of a molecularly imprinted polymeric sensor based on a bio-inspired polymer |
| title_full_unstemmed | Greenness assessment of a molecularly imprinted polymeric sensor based on a bio-inspired polymer |
| title_short | Greenness assessment of a molecularly imprinted polymeric sensor based on a bio-inspired polymer |
| title_sort | greenness assessment of a molecularly imprinted polymeric sensor based on a bio inspired polymer |
| topic | Mussel-inspired polymers Poly (methyldopa) Formoterol Molecularly-imprinted polymers Electrochemical sensors, Green analytical procedure index, red green blue model |
| url | https://doi.org/10.1186/s13065-024-01313-0 |
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