Nosocomial infection prevalence in patients undergoing extracorporeal membrane oxygenation (ECMO): protocol for a point prevalence study across Australia and New Zealand
Introduction Extracorporeal membrane oxygenation (ECMO) provides cardiac and/or respiratory support when other therapies fail. Nosocomial infection is reported in up to 64% of patients receiving ECMO and increases morbidity and mortality. These patients are at high risk of infection due, in part, to...
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BMJ Publishing Group
2019-07-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/7/e029293.full |
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| author | John F Fraser Rachael Parke Amanda Corley India Lye Jayshree D Lavana Abhilasha Ahuja Chris M Anstey Paul Jarrett Emma Haisz Vincent Pellegrino Hergen Buscher |
| author_facet | John F Fraser Rachael Parke Amanda Corley India Lye Jayshree D Lavana Abhilasha Ahuja Chris M Anstey Paul Jarrett Emma Haisz Vincent Pellegrino Hergen Buscher |
| author_sort | John F Fraser |
| collection | DOAJ |
| description | Introduction Extracorporeal membrane oxygenation (ECMO) provides cardiac and/or respiratory support when other therapies fail. Nosocomial infection is reported in up to 64% of patients receiving ECMO and increases morbidity and mortality. These patients are at high risk of infection due, in part, to the multiple invasive devices required in their management, the largest being the cannulae through which ECMO is delivered. Prevalence of nosocomial infection in ECMO patients, including ECMO cannula-related infection, is not well described across Australia and New Zealand.Methods and analysis This is a prospective, observational point prevalence study of 12 months duration conducted at 11 ECMO centres across Australia and New Zealand. Data will be collected for every patient receiving ECMO during 12 predetermined data collection weeks. The primary outcome is the prevalence of laboratory-confirmed bloodstream infection, and suspected or probable nosocomial infections; and the secondary outcomes include describing ECMO cannula dressing and securement practices, and adherence to local dressing and securement guidelines. Data collection will be finalised by March 2019.Ethics and dissemination Relevant ethical and governance approvals have been received. Study results will describe the prevalence of suspected and confirmed nosocomial infection in adult, paediatric and neonatal patients receiving ECMO across Australia and New Zealand. It is expected that the results will be hypothesis generating and lead to interventional trials aimed at reducing the high infection rates seen in this cohort. Results will be published in peer-reviewed journals and presented at relevant conferences.Trial registration number ANZCTRN12618001109291; Pre-results. |
| format | Article |
| id | doaj-art-27afb9ac3ee247ac8d68499332994aa7 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-27afb9ac3ee247ac8d68499332994aa72024-11-23T09:45:07ZengBMJ Publishing GroupBMJ Open2044-60552019-07-019710.1136/bmjopen-2019-029293Nosocomial infection prevalence in patients undergoing extracorporeal membrane oxygenation (ECMO): protocol for a point prevalence study across Australia and New ZealandJohn F Fraser0Rachael Parke1Amanda Corley2India Lye3Jayshree D Lavana4Abhilasha Ahuja5Chris M Anstey6Paul Jarrett7Emma Haisz8Vincent Pellegrino9Hergen Buscher106 Paediatric Research in Emergency Departments International Collaborative (PREDICT), Brisbane, Queensland, Australia3 School of Nursing, The University of Auckland, Auckland, New ZealandSchool of Nursing Midwifery and Social Work, UQ Centre for Clinical Research, The University of Queensland, Herston, Queensland, AustraliaCritical Care Research Group, The Prince Charles Hospital and University of Queensland, Brisbane, Queensland, AustraliaAdult Intensive Care Services, The Prince Charles Hospital, Brisbane, Queensland, AustraliaAdult Intensive Care Services, The Prince Charles Hospital, Brisbane, Queensland, AustraliaIntensive Care Unit, Sunshine Coast University Hospital, Birtinya, Queensland, AustraliaCritical Care Research Group, The Prince Charles Hospital and University of Queensland, Brisbane, Queensland, AustraliaPaediatric Intensive Care Unit, Queensland Children’s Hospital, South Brisbane, Queensland, AustraliaDepartment of Intensive Care, Alfred Hospital, Melbourne, Victoria, Australia10 Intensive Care Unit, St Vincent`s Hospital Sydney, Darlinghurst, New South Wales, AustraliaIntroduction Extracorporeal membrane oxygenation (ECMO) provides cardiac and/or respiratory support when other therapies fail. Nosocomial infection is reported in up to 64% of patients receiving ECMO and increases morbidity and mortality. These patients are at high risk of infection due, in part, to the multiple invasive devices required in their management, the largest being the cannulae through which ECMO is delivered. Prevalence of nosocomial infection in ECMO patients, including ECMO cannula-related infection, is not well described across Australia and New Zealand.Methods and analysis This is a prospective, observational point prevalence study of 12 months duration conducted at 11 ECMO centres across Australia and New Zealand. Data will be collected for every patient receiving ECMO during 12 predetermined data collection weeks. The primary outcome is the prevalence of laboratory-confirmed bloodstream infection, and suspected or probable nosocomial infections; and the secondary outcomes include describing ECMO cannula dressing and securement practices, and adherence to local dressing and securement guidelines. Data collection will be finalised by March 2019.Ethics and dissemination Relevant ethical and governance approvals have been received. Study results will describe the prevalence of suspected and confirmed nosocomial infection in adult, paediatric and neonatal patients receiving ECMO across Australia and New Zealand. It is expected that the results will be hypothesis generating and lead to interventional trials aimed at reducing the high infection rates seen in this cohort. Results will be published in peer-reviewed journals and presented at relevant conferences.Trial registration number ANZCTRN12618001109291; Pre-results.https://bmjopen.bmj.com/content/9/7/e029293.full |
| spellingShingle | John F Fraser Rachael Parke Amanda Corley India Lye Jayshree D Lavana Abhilasha Ahuja Chris M Anstey Paul Jarrett Emma Haisz Vincent Pellegrino Hergen Buscher Nosocomial infection prevalence in patients undergoing extracorporeal membrane oxygenation (ECMO): protocol for a point prevalence study across Australia and New Zealand BMJ Open |
| title | Nosocomial infection prevalence in patients undergoing extracorporeal membrane oxygenation (ECMO): protocol for a point prevalence study across Australia and New Zealand |
| title_full | Nosocomial infection prevalence in patients undergoing extracorporeal membrane oxygenation (ECMO): protocol for a point prevalence study across Australia and New Zealand |
| title_fullStr | Nosocomial infection prevalence in patients undergoing extracorporeal membrane oxygenation (ECMO): protocol for a point prevalence study across Australia and New Zealand |
| title_full_unstemmed | Nosocomial infection prevalence in patients undergoing extracorporeal membrane oxygenation (ECMO): protocol for a point prevalence study across Australia and New Zealand |
| title_short | Nosocomial infection prevalence in patients undergoing extracorporeal membrane oxygenation (ECMO): protocol for a point prevalence study across Australia and New Zealand |
| title_sort | nosocomial infection prevalence in patients undergoing extracorporeal membrane oxygenation ecmo protocol for a point prevalence study across australia and new zealand |
| url | https://bmjopen.bmj.com/content/9/7/e029293.full |
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