Evaluating the effectiveness of adjuvant radiotherapy in addition to surgery versus surgery alone at improving oncologic outcomes for early stage buccal carcinoma: a systematic review
Abstract Objective To systematically review the evidence to evaluate oncologic outcomes for patients with early stage buccal squamous cell carcinoma treated with surgery versus surgery and adjuvant radiation therapy. Data sources Ovid MedLine, EMBASE, Google Scholar, PubMed. Review methods The prima...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-12-01
|
| Series: | Journal of Otolaryngology - Head and Neck Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40463-019-0396-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832544183545495552 |
|---|---|
| author | Corliss Ann Elizabeth Best Alexandra Elizabeth Quimby Brittany Ann Barbara Best Dean Fergusson Hussain Alsaffar |
| author_facet | Corliss Ann Elizabeth Best Alexandra Elizabeth Quimby Brittany Ann Barbara Best Dean Fergusson Hussain Alsaffar |
| author_sort | Corliss Ann Elizabeth Best |
| collection | DOAJ |
| description | Abstract Objective To systematically review the evidence to evaluate oncologic outcomes for patients with early stage buccal squamous cell carcinoma treated with surgery versus surgery and adjuvant radiation therapy. Data sources Ovid MedLine, EMBASE, Google Scholar, PubMed. Review methods The primary purpose was to perform a systematic review to determine the published literature comparing oncologic outcomes of patients with early stage (Stages I&II) buccal mucosal squamous cell carcinoma, treated with surgical resection alone versus surgery plus adjuvant radiation therapy. Oncologic outcomes of interest were overall survival, locoregional recurrence, and disease specific survival. The secondary aim was to perform a meta-analysis to quantitively compare and summarize the data on oncologic outcomes between treatments. Results A total of 1457 studies were screened and five retrospective cohort studies (n = 733 patients) were eligible for quantitative analysis. Overall study quality was moderate to high. Pooled relative risk ratios using a fixed effects model did not reveal any statistically significant difference in overall survival (p = 0.70) or locoregional recurrence rates (p = 0.72) in Stage I and II disease. Conclusions These results demonstrate there is sparse evidence comparing oncologic outcomes for early stage buccal squamous cell carcinoma treated with surgery alone versus surgery and adjuvant radiation therapy. Our findings based on a limited body of evidence suggest no obvious benefit in the addition of adjuvant radiation therapy, however robust randomized trials are warranted to reach firm conclusions. |
| format | Article |
| id | doaj-art-27afb3c1a059413c87f12db63acd2879 |
| institution | Kabale University |
| issn | 1916-0216 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-27afb3c1a059413c87f12db63acd28792025-02-03T10:51:14ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162019-12-0148111010.1186/s40463-019-0396-xEvaluating the effectiveness of adjuvant radiotherapy in addition to surgery versus surgery alone at improving oncologic outcomes for early stage buccal carcinoma: a systematic reviewCorliss Ann Elizabeth Best0Alexandra Elizabeth Quimby1Brittany Ann Barbara Best2Dean Fergusson3Hussain Alsaffar4The Department of Otolaryngology – Head and Neck Surgery, University of OttawaThe Department of Otolaryngology – Head and Neck Surgery, University of OttawaThe Department of Otolaryngology – Head and Neck Surgery, University of OttawaOttawa Hospital Research InstituteThe Department of Otolaryngology – Head and Neck Surgery, University of OttawaAbstract Objective To systematically review the evidence to evaluate oncologic outcomes for patients with early stage buccal squamous cell carcinoma treated with surgery versus surgery and adjuvant radiation therapy. Data sources Ovid MedLine, EMBASE, Google Scholar, PubMed. Review methods The primary purpose was to perform a systematic review to determine the published literature comparing oncologic outcomes of patients with early stage (Stages I&II) buccal mucosal squamous cell carcinoma, treated with surgical resection alone versus surgery plus adjuvant radiation therapy. Oncologic outcomes of interest were overall survival, locoregional recurrence, and disease specific survival. The secondary aim was to perform a meta-analysis to quantitively compare and summarize the data on oncologic outcomes between treatments. Results A total of 1457 studies were screened and five retrospective cohort studies (n = 733 patients) were eligible for quantitative analysis. Overall study quality was moderate to high. Pooled relative risk ratios using a fixed effects model did not reveal any statistically significant difference in overall survival (p = 0.70) or locoregional recurrence rates (p = 0.72) in Stage I and II disease. Conclusions These results demonstrate there is sparse evidence comparing oncologic outcomes for early stage buccal squamous cell carcinoma treated with surgery alone versus surgery and adjuvant radiation therapy. Our findings based on a limited body of evidence suggest no obvious benefit in the addition of adjuvant radiation therapy, however robust randomized trials are warranted to reach firm conclusions.https://doi.org/10.1186/s40463-019-0396-xBuccal squamous cell carcinomaOral cavity squamous cell carcinomaSurgeryRadiationEarly stage diseaseOncologic outcomes |
| spellingShingle | Corliss Ann Elizabeth Best Alexandra Elizabeth Quimby Brittany Ann Barbara Best Dean Fergusson Hussain Alsaffar Evaluating the effectiveness of adjuvant radiotherapy in addition to surgery versus surgery alone at improving oncologic outcomes for early stage buccal carcinoma: a systematic review Journal of Otolaryngology - Head and Neck Surgery Buccal squamous cell carcinoma Oral cavity squamous cell carcinoma Surgery Radiation Early stage disease Oncologic outcomes |
| title | Evaluating the effectiveness of adjuvant radiotherapy in addition to surgery versus surgery alone at improving oncologic outcomes for early stage buccal carcinoma: a systematic review |
| title_full | Evaluating the effectiveness of adjuvant radiotherapy in addition to surgery versus surgery alone at improving oncologic outcomes for early stage buccal carcinoma: a systematic review |
| title_fullStr | Evaluating the effectiveness of adjuvant radiotherapy in addition to surgery versus surgery alone at improving oncologic outcomes for early stage buccal carcinoma: a systematic review |
| title_full_unstemmed | Evaluating the effectiveness of adjuvant radiotherapy in addition to surgery versus surgery alone at improving oncologic outcomes for early stage buccal carcinoma: a systematic review |
| title_short | Evaluating the effectiveness of adjuvant radiotherapy in addition to surgery versus surgery alone at improving oncologic outcomes for early stage buccal carcinoma: a systematic review |
| title_sort | evaluating the effectiveness of adjuvant radiotherapy in addition to surgery versus surgery alone at improving oncologic outcomes for early stage buccal carcinoma a systematic review |
| topic | Buccal squamous cell carcinoma Oral cavity squamous cell carcinoma Surgery Radiation Early stage disease Oncologic outcomes |
| url | https://doi.org/10.1186/s40463-019-0396-x |
| work_keys_str_mv | AT corlissannelizabethbest evaluatingtheeffectivenessofadjuvantradiotherapyinadditiontosurgeryversussurgeryaloneatimprovingoncologicoutcomesforearlystagebuccalcarcinomaasystematicreview AT alexandraelizabethquimby evaluatingtheeffectivenessofadjuvantradiotherapyinadditiontosurgeryversussurgeryaloneatimprovingoncologicoutcomesforearlystagebuccalcarcinomaasystematicreview AT brittanyannbarbarabest evaluatingtheeffectivenessofadjuvantradiotherapyinadditiontosurgeryversussurgeryaloneatimprovingoncologicoutcomesforearlystagebuccalcarcinomaasystematicreview AT deanfergusson evaluatingtheeffectivenessofadjuvantradiotherapyinadditiontosurgeryversussurgeryaloneatimprovingoncologicoutcomesforearlystagebuccalcarcinomaasystematicreview AT hussainalsaffar evaluatingtheeffectivenessofadjuvantradiotherapyinadditiontosurgeryversussurgeryaloneatimprovingoncologicoutcomesforearlystagebuccalcarcinomaasystematicreview |