Contact-number-driven virus evolution: A multi-level modeling framework for the evolution of acute or persistent RNA virus infection.

Viruses evolve in infected host populations, and host population dynamics affect viral evolution. RNA viruses with a short duration of infection and a high peak viral load, such as SARS-CoV-2, are maintained in human populations. By contrast, RNA viruses characterized by a long infection duration an...

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Bibliographic Details
Main Authors: Junya Sunagawa, Ryo Komorizono, Hyeongki Park, William S Hart, Robin N Thompson, Akiko Makino, Keizo Tomonaga, Shingo Iwami, Ryo Yamaguchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-05-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1011173
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