Endogenous micropeptides as potential diagnostic biomarkers and therapeutic drugs
Micropeptides, these small proteins derived from non-coding RNA, typically consist of no more than 100 amino acids in length. Despite the challenges in analysis and identification, their various critical functions within organisms cannot be overlooked. They play a significant role in maintaining ene...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1545575/full |
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| author | Aixi Zhong Aixi Zhong Shuai Li Jingxuan Zhang Jingyuan Zhao Chenhui Yao |
| author_facet | Aixi Zhong Aixi Zhong Shuai Li Jingxuan Zhang Jingyuan Zhao Chenhui Yao |
| author_sort | Aixi Zhong |
| collection | DOAJ |
| description | Micropeptides, these small proteins derived from non-coding RNA, typically consist of no more than 100 amino acids in length. Despite the challenges in analysis and identification, their various critical functions within organisms cannot be overlooked. They play a significant role in maintaining energy metabolism balance, regulating the immune system, and influencing the development of tumors, which also gives them a decisive impact on the occurrence and development of various diseases. This review aims to outline the role and potential value of micropeptides, introducing their tissue classification and distribution, biological functions, and mechanisms, with a focus on their potential as diagnostic markers and therapeutic drugs. |
| format | Article |
| id | doaj-art-27975adf221c482f911d2f5c8c7928af |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-27975adf221c482f911d2f5c8c7928af2025-08-20T02:16:21ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-04-011610.3389/fphar.2025.15455751545575Endogenous micropeptides as potential diagnostic biomarkers and therapeutic drugsAixi Zhong0Aixi Zhong1Shuai Li2Jingxuan Zhang3Jingyuan Zhao4Chenhui Yao5The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDalian Medical University, Dalian, ChinaThe First Affiliated Hospital of Dalian Medical University, Dalian, ChinaZhongshan College of Dalian Medical University, Dalian, ChinaCentral Hospital of Dalian University of Technology, Dalian, ChinaThe First Affiliated Hospital of Dalian Medical University, Dalian, ChinaMicropeptides, these small proteins derived from non-coding RNA, typically consist of no more than 100 amino acids in length. Despite the challenges in analysis and identification, their various critical functions within organisms cannot be overlooked. They play a significant role in maintaining energy metabolism balance, regulating the immune system, and influencing the development of tumors, which also gives them a decisive impact on the occurrence and development of various diseases. This review aims to outline the role and potential value of micropeptides, introducing their tissue classification and distribution, biological functions, and mechanisms, with a focus on their potential as diagnostic markers and therapeutic drugs.https://www.frontiersin.org/articles/10.3389/fphar.2025.1545575/fullmicropeptidesdiagnostic biomarkersdrugsnoncoding RNAs (ncRNAs)peptide |
| spellingShingle | Aixi Zhong Aixi Zhong Shuai Li Jingxuan Zhang Jingyuan Zhao Chenhui Yao Endogenous micropeptides as potential diagnostic biomarkers and therapeutic drugs Frontiers in Pharmacology micropeptides diagnostic biomarkers drugs noncoding RNAs (ncRNAs) peptide |
| title | Endogenous micropeptides as potential diagnostic biomarkers and therapeutic drugs |
| title_full | Endogenous micropeptides as potential diagnostic biomarkers and therapeutic drugs |
| title_fullStr | Endogenous micropeptides as potential diagnostic biomarkers and therapeutic drugs |
| title_full_unstemmed | Endogenous micropeptides as potential diagnostic biomarkers and therapeutic drugs |
| title_short | Endogenous micropeptides as potential diagnostic biomarkers and therapeutic drugs |
| title_sort | endogenous micropeptides as potential diagnostic biomarkers and therapeutic drugs |
| topic | micropeptides diagnostic biomarkers drugs noncoding RNAs (ncRNAs) peptide |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1545575/full |
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