Multidimensional Burden of Moderate-to-Severe Atopic Dermatitis in Adolescent and Adult Patients from Portugal and Greece: Results from the Global Cross-Sectional Study MEASURE-AD
Abstract Introduction Despite significant progress observed in the treatment of atopic dermatitis (AD), a considerable number of patients with severe disease are undertreated and have inadequate symptom control. This may be due to several reasons, such as underestimation of the implications of the d...
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Adis, Springer Healthcare
2025-04-01
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| Series: | Dermatology and Therapy |
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| Online Access: | https://doi.org/10.1007/s13555-025-01414-1 |
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| author | Pedro Mendes-Bastos Elisavet Lazaridou Tiago Torres Charalampos Aggelakopoulos Ioannis Katsantonis Pantelis Aronis Dimitrios Rigopoulos Filomena Azevedo Felicidade Santiago Markos Papakonstantis Paulo Varela Vera S. G. Ribeiro Aikaterini Kollia Evaggelia Papadavid |
| author_facet | Pedro Mendes-Bastos Elisavet Lazaridou Tiago Torres Charalampos Aggelakopoulos Ioannis Katsantonis Pantelis Aronis Dimitrios Rigopoulos Filomena Azevedo Felicidade Santiago Markos Papakonstantis Paulo Varela Vera S. G. Ribeiro Aikaterini Kollia Evaggelia Papadavid |
| author_sort | Pedro Mendes-Bastos |
| collection | DOAJ |
| description | Abstract Introduction Despite significant progress observed in the treatment of atopic dermatitis (AD), a considerable number of patients with severe disease are undertreated and have inadequate symptom control. This may be due to several reasons, such as underestimation of the implications of the disease on patients, families, and society, as well as inconsistent access to effective treatment. The multidimensional disease burden of AD includes other atopic comorbidities, sleep disturbance, and functional impairment and secondary consequences, including neuropsychiatric issues (anxiety and depression) and reduced health-related quality of life. Methods MEASURE-AD was a global, cross-sectional observational study in adolescents and adults with moderate-to-severe AD, conducted to describe disease burden, treatment patterns, and healthcare resource utilization. Results The results concerning patients from Portugal and Greece indicate moderate-to-severe disease for most of the population with frequent disease flares. The quality of life of both adolescents and adults was greatly affected, mainly owing to itch. One out of five patients perceived that their treatment was not effectively controlling AD. Disease resulted in important out-of-pocket expenses and loss of productivity. Conclusions Understanding and recognizing the complex burden of moderate-to-severe AD is required to encourage and guide changes in public policy for the effective management of patients. |
| format | Article |
| id | doaj-art-279510a74ca14057bddd29ca0d2e7db3 |
| institution | OA Journals |
| issn | 2193-8210 2190-9172 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Dermatology and Therapy |
| spelling | doaj-art-279510a74ca14057bddd29ca0d2e7db32025-08-20T01:52:25ZengAdis, Springer HealthcareDermatology and Therapy2193-82102190-91722025-04-011561487150510.1007/s13555-025-01414-1Multidimensional Burden of Moderate-to-Severe Atopic Dermatitis in Adolescent and Adult Patients from Portugal and Greece: Results from the Global Cross-Sectional Study MEASURE-ADPedro Mendes-Bastos0Elisavet Lazaridou1Tiago Torres2Charalampos Aggelakopoulos3Ioannis Katsantonis4Pantelis Aronis5Dimitrios Rigopoulos6Filomena Azevedo7Felicidade Santiago8Markos Papakonstantis9Paulo Varela10Vera S. G. Ribeiro11Aikaterini Kollia12Evaggelia Papadavid13Dermatology Center, Hospital CUF Descobertas2nd Department of Dermatology-Venereology, Aristotle University School of Medicine, “Papageorgiou” General HospitalUnidade Local de Saúde de Santo António, Largo do Prof. Abel SalazarDermatology Department, Athens Naval HospitalDermatology Department, Tzaneio General HospitalClinic of Dermatology, Hellenic Airforce 251 General Hospital1st Department of Dermatology and Venereology, National and Kapodistrian University of Athens School of MedicineUnidade Local de Saúde de São João, Alameda Prof. Hernâni MonteiroUnidade Local de Saúde da Região de Leiria, Hospital de Santo André, R. de Santo AndréClinic of Dermatology, 401 General Military Hospital of AthensUnidade Local de Saúde deGaia e Espinho, R. Conceição FernandesAbbVie, Lda.; Estrada Alfragide 67 Alfrapark, Edifício DAbbVie Pharmaceuticals S.A2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, “Attikon” University General HospitalAbstract Introduction Despite significant progress observed in the treatment of atopic dermatitis (AD), a considerable number of patients with severe disease are undertreated and have inadequate symptom control. This may be due to several reasons, such as underestimation of the implications of the disease on patients, families, and society, as well as inconsistent access to effective treatment. The multidimensional disease burden of AD includes other atopic comorbidities, sleep disturbance, and functional impairment and secondary consequences, including neuropsychiatric issues (anxiety and depression) and reduced health-related quality of life. Methods MEASURE-AD was a global, cross-sectional observational study in adolescents and adults with moderate-to-severe AD, conducted to describe disease burden, treatment patterns, and healthcare resource utilization. Results The results concerning patients from Portugal and Greece indicate moderate-to-severe disease for most of the population with frequent disease flares. The quality of life of both adolescents and adults was greatly affected, mainly owing to itch. One out of five patients perceived that their treatment was not effectively controlling AD. Disease resulted in important out-of-pocket expenses and loss of productivity. Conclusions Understanding and recognizing the complex burden of moderate-to-severe AD is required to encourage and guide changes in public policy for the effective management of patients.https://doi.org/10.1007/s13555-025-01414-1Atopic dermatitisBurden of diseaseExpensesProductivityQuality of lifeSymptom control |
| spellingShingle | Pedro Mendes-Bastos Elisavet Lazaridou Tiago Torres Charalampos Aggelakopoulos Ioannis Katsantonis Pantelis Aronis Dimitrios Rigopoulos Filomena Azevedo Felicidade Santiago Markos Papakonstantis Paulo Varela Vera S. G. Ribeiro Aikaterini Kollia Evaggelia Papadavid Multidimensional Burden of Moderate-to-Severe Atopic Dermatitis in Adolescent and Adult Patients from Portugal and Greece: Results from the Global Cross-Sectional Study MEASURE-AD Dermatology and Therapy Atopic dermatitis Burden of disease Expenses Productivity Quality of life Symptom control |
| title | Multidimensional Burden of Moderate-to-Severe Atopic Dermatitis in Adolescent and Adult Patients from Portugal and Greece: Results from the Global Cross-Sectional Study MEASURE-AD |
| title_full | Multidimensional Burden of Moderate-to-Severe Atopic Dermatitis in Adolescent and Adult Patients from Portugal and Greece: Results from the Global Cross-Sectional Study MEASURE-AD |
| title_fullStr | Multidimensional Burden of Moderate-to-Severe Atopic Dermatitis in Adolescent and Adult Patients from Portugal and Greece: Results from the Global Cross-Sectional Study MEASURE-AD |
| title_full_unstemmed | Multidimensional Burden of Moderate-to-Severe Atopic Dermatitis in Adolescent and Adult Patients from Portugal and Greece: Results from the Global Cross-Sectional Study MEASURE-AD |
| title_short | Multidimensional Burden of Moderate-to-Severe Atopic Dermatitis in Adolescent and Adult Patients from Portugal and Greece: Results from the Global Cross-Sectional Study MEASURE-AD |
| title_sort | multidimensional burden of moderate to severe atopic dermatitis in adolescent and adult patients from portugal and greece results from the global cross sectional study measure ad |
| topic | Atopic dermatitis Burden of disease Expenses Productivity Quality of life Symptom control |
| url | https://doi.org/10.1007/s13555-025-01414-1 |
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