Antisense oligonucleotides targeting the SARS-CoV-2 nucleocapsid gene decrease viral titers in hamsters

Antisense oligonucleotides targeting the SARS-CoV-2 nucleocapsid gene decrease viral titers in hamsters

SARS-CoV-2 is a positive, single-stranded RNA coronavirus responsible for the COVID-19 pandemic. The emergence of new variants and the limited efficacy of current antivirals demonstrate the need for novel therapeutic strategies. Here, we present the design, screening, and evaluation of antisense oli...

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Bibliographic Details
Main Authors: Christopher Fitzpatrick, Nicolas Meunier, Sophie Lepoder, Sophie Dhorne-Pollet, Bruno Da Costa, Bernard Klonjkowki, Jean-François Eléouët, Verónica A. Burzio, Bernard Delmas, Eric Barrey
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides
Therapies and Applications
antiviral
RNA therapy
COVID-19
nucleocapsid
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125001660
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