Gedunin Mitigates <i>Cutibacterium acnes</i>-Induced Skin Inflammation by Inhibiting the NF-κB Pathway

Gedunin Mitigates <i>Cutibacterium acnes</i>-Induced Skin Inflammation by Inhibiting the NF-κB Pathway

<b>Background/Objectives</b>: <i>Cutibacterium acnes (C. acnes)</i>, a bacterium residing in hair follicles, triggers acne by inducing monocyte-mediated inflammatory cytokine production. Gedunin, a limonoid derived from <i>Azadirachta indica</i> (commonly known as...

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Bibliographic Details
Main Authors: Ju Kyoung Sim, Ye Ji Heo, Jin Hak Shin, Seon Sook Kim, Su Ryeon Seo
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Pharmaceuticals
Subjects:
<i>Cutibacterium acnes</i> (<i>C. acnes</i>)
gedunin
skin inflammation
NF-κB
NLRP3 inflammasome
acne vulgaris
Online Access:https://www.mdpi.com/1424-8247/18/1/71
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