Phosphorylation of POU3F3 Mediated Nuclear Translocation Promotes Proliferation in Non‐Small Cell Lung Cancer through Accelerating ATP5PF Transcription and ATP Production

Phosphorylation of POU3F3 Mediated Nuclear Translocation Promotes Proliferation in Non‐Small Cell Lung Cancer through Accelerating ATP5PF Transcription and ATP Production

Abstract Targeting oxidative phosphorylation (OXPHOS) through inhibiting the electron transport chain (ETC) has shown promising pre‐clinical efficacy in cancer therapy. Although aerobic glycolysis is a hallmark of cancer, emerging evidence suggest OXPHOS is frequently enhanced, providing metabolic a...

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Main Authors: Qi‐Gang Zeng, Le Li, Tao Chang, Yong Sun, Bin Zheng, Ling‐Na Xue, Chao‐Ling Liu, Xia‐Qing Li, Ruo‐Tong Huang, Jia‐Xin Gu, Zhao‐Rong An, Hao‐Tao Yao, Dan‐Yang Zhou, Jun Fan, Yong Dai
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
ATP5PF
NSCLC
OXPHOS
POU3F3
Online Access:https://doi.org/10.1002/advs.202411503
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