Very small embryonic-like stem cells (VSELs) on the way for potential applications in regenerative medicine
Evidence has accumulated that adult tissues contain a population of early development stem cells capable of differentiating across germ layers into various types of cells. Our group purified these rare cells, naming them very small embryonic-like stem cells (VSELs). With their broad differentiation...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1564964/full |
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| author | Kannathasan Thetchinamoorthy Justyna Jarczak Patrycja Kieszek Diana Wierzbicka Janina Ratajczak Magdalena Kucia Mariusz Z. Ratajczak Mariusz Z. Ratajczak |
| author_facet | Kannathasan Thetchinamoorthy Justyna Jarczak Patrycja Kieszek Diana Wierzbicka Janina Ratajczak Magdalena Kucia Mariusz Z. Ratajczak Mariusz Z. Ratajczak |
| author_sort | Kannathasan Thetchinamoorthy |
| collection | DOAJ |
| description | Evidence has accumulated that adult tissues contain a population of early development stem cells capable of differentiating across germ layers into various types of cells. Our group purified these rare cells, naming them very small embryonic-like stem cells (VSELs). With their broad differentiation potential, VSELs have emerged as a new candidate population for clinical applications. This advancement is now possible due to our recent development of a model for ex vivo expansion of these rare cells. Importantly, no evidence suggests that VSELs, isolated from adult tissues, can form teratomas. In this review paper, we update current research on these cells reported in our laboratory as well as in those of several independent investigators. |
| format | Article |
| id | doaj-art-2776c3e20b4843f1b48ffe0a8fdd3506 |
| institution | DOAJ |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-2776c3e20b4843f1b48ffe0a8fdd35062025-08-20T02:58:11ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-03-011310.3389/fbioe.2025.15649641564964Very small embryonic-like stem cells (VSELs) on the way for potential applications in regenerative medicineKannathasan Thetchinamoorthy0Justyna Jarczak1Patrycja Kieszek2Diana Wierzbicka3Janina Ratajczak4Magdalena Kucia5Mariusz Z. Ratajczak6Mariusz Z. Ratajczak7Laboratory of Regenerative Medicine, Medical University of Warsaw, Warsaw, PolandLaboratory of Regenerative Medicine, Medical University of Warsaw, Warsaw, PolandLaboratory of Regenerative Medicine, Medical University of Warsaw, Warsaw, PolandLaboratory of Regenerative Medicine, Medical University of Warsaw, Warsaw, PolandStem Cell Institute at Graham Brown Cancer Center, University of Louisville, Louisville, CO, United StatesLaboratory of Regenerative Medicine, Medical University of Warsaw, Warsaw, PolandLaboratory of Regenerative Medicine, Medical University of Warsaw, Warsaw, PolandStem Cell Institute at Graham Brown Cancer Center, University of Louisville, Louisville, CO, United StatesEvidence has accumulated that adult tissues contain a population of early development stem cells capable of differentiating across germ layers into various types of cells. Our group purified these rare cells, naming them very small embryonic-like stem cells (VSELs). With their broad differentiation potential, VSELs have emerged as a new candidate population for clinical applications. This advancement is now possible due to our recent development of a model for ex vivo expansion of these rare cells. Importantly, no evidence suggests that VSELs, isolated from adult tissues, can form teratomas. In this review paper, we update current research on these cells reported in our laboratory as well as in those of several independent investigators.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1564964/fullpluripotent stem cellstissue organ regenerationvery small embryonic-like stem cells (VSELs)embryonic stem cellsinduced pluripotent stem cells |
| spellingShingle | Kannathasan Thetchinamoorthy Justyna Jarczak Patrycja Kieszek Diana Wierzbicka Janina Ratajczak Magdalena Kucia Mariusz Z. Ratajczak Mariusz Z. Ratajczak Very small embryonic-like stem cells (VSELs) on the way for potential applications in regenerative medicine Frontiers in Bioengineering and Biotechnology pluripotent stem cells tissue organ regeneration very small embryonic-like stem cells (VSELs) embryonic stem cells induced pluripotent stem cells |
| title | Very small embryonic-like stem cells (VSELs) on the way for potential applications in regenerative medicine |
| title_full | Very small embryonic-like stem cells (VSELs) on the way for potential applications in regenerative medicine |
| title_fullStr | Very small embryonic-like stem cells (VSELs) on the way for potential applications in regenerative medicine |
| title_full_unstemmed | Very small embryonic-like stem cells (VSELs) on the way for potential applications in regenerative medicine |
| title_short | Very small embryonic-like stem cells (VSELs) on the way for potential applications in regenerative medicine |
| title_sort | very small embryonic like stem cells vsels on the way for potential applications in regenerative medicine |
| topic | pluripotent stem cells tissue organ regeneration very small embryonic-like stem cells (VSELs) embryonic stem cells induced pluripotent stem cells |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1564964/full |
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