Correlation between daily physical activity and intestinal microbiota in perimenopausal women
This study aimed to examine the correlation between daily physical activity levels and gut microbiota during the perimenopausal period. To explore the physiopathological traits of perimenopause women, and provide a theoretical basis for the development of menopause exercise intervention program. In...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-05-01
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| Series: | Sports Medicine and Health Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266633762400026X |
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| author | Yanqiu Zheng Junyu Ke JinBin Song Xuyu Li Rongman Kuang Haiyan Wang Shuang Li Yanwu Li |
| author_facet | Yanqiu Zheng Junyu Ke JinBin Song Xuyu Li Rongman Kuang Haiyan Wang Shuang Li Yanwu Li |
| author_sort | Yanqiu Zheng |
| collection | DOAJ |
| description | This study aimed to examine the correlation between daily physical activity levels and gut microbiota during the perimenopausal period. To explore the physiopathological traits of perimenopause women, and provide a theoretical basis for the development of menopause exercise intervention program. In this study, daily physical activity was assessed using the ActiGraph wGT3X-BT wearable sensor, and 16S rRNA sequencing was employed to analyze gut microbiota diversity and composition. Comparative analysis was conducted to evaluate the association between physical activity and specific phyla and genera in the gut microbiota, comparing perimenopausal women to youth women. The results showed perimenopausal women exhibited significantly lower levels of daily physical activity, including Kcals, metabolic equivalents (METs), and moderate-to-vigorous physical activity (MVPA), compared to youth women. The composition of the gut microbiota was markedly different between the two groups. Specifically, the abundance of Acidobacteria, Chloroflexi, Nitrospirae, and Gemmatimonadetes were lower at the phylum level (p < 0.01). Collinsella, Ruminococcus gnavus, Rothia, Haemophilus, Sphingomonas, Lactobacillales, and Lactococcus were lower at the genus level, while Phascolarctobacterium, Paraprevotella, Acinetobacter, Flavonifractor, and Intestinimonas exhibited a significant increase (p < 0.05, p < 0.01). Furthermore, a positive correlation was observed between Chloroflexi or Sphingomonas and physical activity (kcals, METs, and MVPA), while a negative correlation was found between Intestinimonas and physical activity (METs: p < 0.01, and MVPA: p < 0.05). Doubtlessly, the perimenopausal period is associated with lower levels of physical activity and distinct changes in gut microbiota. Sphingomonas may serve as a sensitive bacterium closely linked to physical activity. |
| format | Article |
| id | doaj-art-27731c875d92428c956abd62a3a2b34b |
| institution | Kabale University |
| issn | 2666-3376 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Sports Medicine and Health Science |
| spelling | doaj-art-27731c875d92428c956abd62a3a2b34b2025-02-01T04:11:59ZengKeAi Communications Co., Ltd.Sports Medicine and Health Science2666-33762025-05-0173230236Correlation between daily physical activity and intestinal microbiota in perimenopausal womenYanqiu Zheng0Junyu Ke1JinBin Song2Xuyu Li3Rongman Kuang4Haiyan Wang5Shuang Li6Yanwu Li7Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, ChinaSchool of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, ChinaSchool of Physical Education, Guangzhou University, Guangzhou, 510006, ChinaSchool of Physical Education, Guangzhou University, Guangzhou, 510006, ChinaSchool of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, ChinaSchool of Physical Education, Guangzhou University, Guangzhou, 510006, China; Corresponding author. School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China; Corresponding author. School of Physical Education, Guangzhou University, Guangzhou, 510006, ChinaThis study aimed to examine the correlation between daily physical activity levels and gut microbiota during the perimenopausal period. To explore the physiopathological traits of perimenopause women, and provide a theoretical basis for the development of menopause exercise intervention program. In this study, daily physical activity was assessed using the ActiGraph wGT3X-BT wearable sensor, and 16S rRNA sequencing was employed to analyze gut microbiota diversity and composition. Comparative analysis was conducted to evaluate the association between physical activity and specific phyla and genera in the gut microbiota, comparing perimenopausal women to youth women. The results showed perimenopausal women exhibited significantly lower levels of daily physical activity, including Kcals, metabolic equivalents (METs), and moderate-to-vigorous physical activity (MVPA), compared to youth women. The composition of the gut microbiota was markedly different between the two groups. Specifically, the abundance of Acidobacteria, Chloroflexi, Nitrospirae, and Gemmatimonadetes were lower at the phylum level (p < 0.01). Collinsella, Ruminococcus gnavus, Rothia, Haemophilus, Sphingomonas, Lactobacillales, and Lactococcus were lower at the genus level, while Phascolarctobacterium, Paraprevotella, Acinetobacter, Flavonifractor, and Intestinimonas exhibited a significant increase (p < 0.05, p < 0.01). Furthermore, a positive correlation was observed between Chloroflexi or Sphingomonas and physical activity (kcals, METs, and MVPA), while a negative correlation was found between Intestinimonas and physical activity (METs: p < 0.01, and MVPA: p < 0.05). Doubtlessly, the perimenopausal period is associated with lower levels of physical activity and distinct changes in gut microbiota. Sphingomonas may serve as a sensitive bacterium closely linked to physical activity.http://www.sciencedirect.com/science/article/pii/S266633762400026XPhysical activityIntestinal microbiotaPerimenopause |
| spellingShingle | Yanqiu Zheng Junyu Ke JinBin Song Xuyu Li Rongman Kuang Haiyan Wang Shuang Li Yanwu Li Correlation between daily physical activity and intestinal microbiota in perimenopausal women Sports Medicine and Health Science Physical activity Intestinal microbiota Perimenopause |
| title | Correlation between daily physical activity and intestinal microbiota in perimenopausal women |
| title_full | Correlation between daily physical activity and intestinal microbiota in perimenopausal women |
| title_fullStr | Correlation between daily physical activity and intestinal microbiota in perimenopausal women |
| title_full_unstemmed | Correlation between daily physical activity and intestinal microbiota in perimenopausal women |
| title_short | Correlation between daily physical activity and intestinal microbiota in perimenopausal women |
| title_sort | correlation between daily physical activity and intestinal microbiota in perimenopausal women |
| topic | Physical activity Intestinal microbiota Perimenopause |
| url | http://www.sciencedirect.com/science/article/pii/S266633762400026X |
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