The flavonoid of Dracocephalum heterophyllum Benth. ameliorates cerebral small vessel disease by inhibiting the autophagy via Angs-Tie2 signaling pathway

The flavonoid of Dracocephalum heterophyllum Benth. ameliorates cerebral small vessel disease by inhibiting the autophagy via Angs-Tie2 signaling pathway

BackgroundCerebral small vessel disease (CSVD) is a common cause of stroke and vascular cognitive impairment. It is urgent to find drugs targeting CSVD. This study explores the therapeutic potential of the flavonoid (DHBF) derived from Dracocephalum heterophyllum Benth., a traditional Tibetan medici...

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Bibliographic Details
Main Authors: Lin Liu, Wen He, Sijing Liu, Yang Li, Peng Wang, Fang Yan, Wenjing Yang, Yongxue Yang, Jinlin Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
flavonoid of Dracocephalum heterophyllum Benth.
human umbilical vein endothelial cells
cerebral small vessel disease
Angiogenin
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1500307/full
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